KEGG   PATHWAY: ctul03013
Entry
ctul03013                   Pathway                                
Name
Nucleocytoplasmic transport - Cyprinodon tularosa (White Sands pupfish)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ctul03013  Nucleocytoplasmic transport
ctul03013

Other DBs
GO: 0050658
Organism
Cyprinodon tularosa (White Sands pupfish) [GN:ctul]
Gene
119771290  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
119771300  nup107; nuclear pore complex protein Nup107 [KO:K14301]
119771451  [KO:K10577]
119772508  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
119772899  xpo4; exportin-4 [KO:K25203]
119772920  [KO:K12160]
119773180  [KO:K14325]
119773421  acin1b; apoptotic chromatin condensation inducer 1b isoform X1 [KO:K12875]
119773832  [KO:K03231]
119773988  pym1; partner of Y14 and mago [KO:K14294]
119774129  [KO:K09291]
119774184  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
119774833  pnn; pinin [KO:K13114]
119774849  eef1a1a; elongation factor 1-alpha 1a [KO:K03231]
119775199  snupn; snurportin-1 isoform X1 [KO:K13151]
119775402  sumo3a; small ubiquitin-related modifier 3-like [KO:K12160]
119775410  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
119776535  nup188; nucleoporin NUP188 [KO:K14311]
119776559  nup54; nucleoporin p54 isoform X1 [KO:K14308]
119777489  ranbp2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
119777668  [KO:K18727]
119777686  nup85; nuclear pore complex protein Nup85 [KO:K14304]
119777688  sumo2a; small ubiquitin like modifier 2a [KO:K12160]
119778219  xpo7; exportin-7 isoform X1 [KO:K18460]
119778363  nup43; nucleoporin Nup43 [KO:K14305]
119778662  xpo1a; exportin-1 isoform X1 [KO:K14290]
119778748  nxt2; NTF2-related export protein 2 [KO:K14285]
119778954  tnpo3; transportin-3 [KO:K15436]
119779365  [KO:K12881]
119779519  nup42; nucleoporin NUP42 [KO:K14321]
119780069  cse1l; exportin-2 [KO:K18423]
119780995  nup37; nucleoporin Nup37 [KO:K14302]
119781171  nup98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
119781390  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
119781529  nup155; nuclear pore complex protein Nup155 [KO:K14312]
119781691  xpo6; exportin-6 [KO:K25204]
119781740  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
119781814  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
119783292  [KO:K18727]
119783341  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
119783893  sumo3b; small ubiquitin-related modifier 3 [KO:K12160]
119784476  thoc3; THO complex subunit 3 [KO:K12880]
119784497  nxf1a; nuclear RNA export factor 1 isoform X1 [KO:K14284]
119784611  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
119784925  phax; phosphorylated adapter RNA export protein [KO:K14291]
119785553  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119786305  upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
119786521  nup88; nucleoporin 88 [KO:K14318]
119786577  thoc5; THO complex subunit 5 homolog [KO:K13174]
119786968  kpna6; importin subunit alpha-7 [KO:K15042]
119787048  kpna7; importin subunit alpha-8 [KO:K15043]
119787127  kpnb3; importin-5 [KO:K20222]
119787161  ndc1; nucleoporin NDC1 [KO:K14315]
119787233  nup160; nuclear pore complex protein Nup160 [KO:K14303]
119787303  ahctf1; protein ELYS isoform X1 [KO:K25129]
119787623  magoh; protein mago nashi homolog [KO:K12877]
119788023  ipo8; importin-8 isoform X1 [KO:K18755]
119788252  nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
119788336  ran; GTP-binding nuclear protein Ran [KO:K07936]
119788571  [KO:K14289]
119789006  kpna1; importin subunit alpha-5 [KO:K23940]
119789130  nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
119789822  nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
119789916  [KO:K25202]
119789993  rae1; mRNA export factor isoform X1 [KO:K14298]
119790083  thoc7; THO complex subunit 7 homolog [KO:K13176]
119790377  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
119790496  [KO:K03231]
119790497  [KO:K03231]
119790566  xpot; exportin-T [KO:K14288]
119790859  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
119791004  rangap1b; ran GTPase-activating protein 1b [KO:K14319]
119791563  ipo7; importin-7 [KO:K20223]
119791682  si:dkey-37o8.1; elongation factor 1-alpha [KO:K03231]
119791771  ddx19; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
119792713  xpo1b; exportin-1 isoform X1 [KO:K14290]
119793336  acin1a; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
119793800  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
119793866  nup50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
119793883  ipo9; importin-9 [KO:K20224]
119793919  nup62l; nucleoporin 62 like [KO:K14306]
119794168  thoc1; THO complex subunit 1 [KO:K12878]
119794399  upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119794657  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
119794724  kpna3; importin subunit alpha-4 [KO:K23583]
119795835  nup153; nuclear pore complex protein Nup153 [KO:K14296]
119796353  nup133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
119796430  tnpo1; transportin-1 [KO:K18752]
119796674  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
119796859  thoc6; THO complex subunit 6 homolog [KO:K13175]
119796880  kpnb1; importin subunit beta-1 [KO:K14293]
119796890  casc3; protein CASC3 [KO:K14323]
119796938  ipo4; importin-4 [KO:K20221]
119797221  sec13; protein SEC13 homolog [KO:K14004]
119797242  nup205; nuclear pore complex protein Nup205 [KO:K14310]
119797260  seh1l; nucleoporin SEH1 [KO:K14299]
119797290  kpna2; importin subunit alpha-1 [KO:K15043]
119797302  kpna4; importin subunit alpha-3 [KO:K23583]
119797322  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
119797450  gle1; nucleoporin GLE1 [KO:K18723]
119798131  pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
119798513  tmem33; transmembrane protein 33 [KO:K20724]
119798724  [KO:K12882]
119799162  aaas; aladin [KO:K14320]
119799257  [KO:K25202]
119799416  rangap1a; ran GTPase-activating protein 1a isoform X1 [KO:K14319]
119799478  zgc:193690; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ctul03015  mRNA surveillance pathway
KO pathway
ko03013   

DBGET integrated database retrieval system