KEGG   PATHWAY: dnm03320
Entry
dnm03320                    Pathway                                
Name
PPAR signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
dnm03320  PPAR signaling pathway
dnm03320

Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101447090  CD36; LOW QUALITY PROTEIN: platelet glycoprotein 4 [KO:K06259]
101417816  SLC27A4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
101435979  SLC27A2; LOW QUALITY PROTEIN: very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
101427445  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
101438816  SLC27A5; bile acyl-CoA synthetase isoform X1 [KO:K08748] [EC:6.2.1.7]
101412753  LOW QUALITY PROTEIN: long-chain fatty acid transport protein 6-like [KO:K08749]
101417672  FABP1; fatty acid-binding protein, liver [KO:K08750]
101435034  FABP2; fatty acid-binding protein, intestinal [KO:K08751]
101442970  FABP3; fatty acid-binding protein, heart [KO:K08752]
101442635  fatty acid-binding protein, adipocyte [KO:K08753]
101417959  fatty acid-binding protein, epidermal [KO:K08754]
101441758  FABP5; fatty acid-binding protein, epidermal [KO:K08754]
101436625  FABP6; gastrotropin [KO:K08755]
101432648  FABP7; fatty acid-binding protein, brain isoform X1 [KO:K08756]
101430243  PPARA; peroxisome proliferator-activated receptor alpha isoform X4 [KO:K07294]
101411907  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
101414688  RXRB; LOW QUALITY PROTEIN: retinoic acid receptor RXR-beta [KO:K08525]
101428198  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101416677  PPARD; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta [KO:K04504]
101418117  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101420631  HMGCS2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:2.3.3.10]
101434984  HMGCS1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X3 [KO:K01641] [EC:2.3.3.10]
101444125  LOW QUALITY PROTEIN: hydroxymethylglutaryl-CoA synthase, cytoplasmic-like [KO:K01641] [EC:2.3.3.10]
101432754  APOA1; apolipoprotein A-I [KO:K08757]
101411206  APOA2; apolipoprotein A-II [KO:K08758]
101433202  APOC3; apolipoprotein C-III [KO:K08759]
101430703  APOA5; apolipoprotein A-V [KO:K09025]
101433817  PLTP; phospholipid transfer protein [KO:K08761]
101434030  ME1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
101439241  ME3; LOW QUALITY PROTEIN: NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
101419118  FADS2; fatty acid desaturase 2 isoform X1 [KO:K10226] [EC:1.14.19.3]
101427856  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
101433841  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
101438362  cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
101440886  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
101426093  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
101411078  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
101411838  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
101423385  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
101433688  acyl-CoA-binding protein [KO:K08762]
101428684  DBI; acyl-CoA-binding protein [KO:K08762]
101432635  diazepam-binding inhibitor-like 5 [KO:K08762]
101424109  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
101411880  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X5 [KO:K01897] [EC:6.2.1.3]
101430516  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
101436689  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
101422219  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
101440936  ACSBG2; long-chain-fatty-acid--CoA ligase ACSBG2 [KO:K15013] [EC:6.2.1.3]
101415428  ACSBG1; LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase ACSBG1 [KO:K15013] [EC:6.2.1.3]
101442975  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
101418828  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101423565  EHHADH; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
101422541  cytochrome P450 4A11 [KO:K07425] [EC:1.14.14.80]
101430748  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
101431612  non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
101434003  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
101419564  peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
101427247  uncharacterized protein LOC101427247 [KO:K00232] [EC:1.3.3.6]
101442926  ACOX2; peroxisomal acyl-coenzyme A oxidase 2 [KO:K10214] [EC:1.17.99.3]
101420863  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101441395  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
101423981  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
101428085  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
101437224  ACADL; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
101427342  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
101432066  ANGPTL4; angiopoietin-related protein 4 [KO:K08767]
101430635  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X4 [KO:K06086]
101415799  PLIN1; perilipin-1 [KO:K08768]
101441643  PLIN2; perilipin-2 [KO:K17284]
101426287  PLIN4; LOW QUALITY PROTEIN: perilipin-4 [KO:K20254]
101427319  PLIN5; perilipin-5 [KO:K20255]
101442588  ADIPOQ; adiponectin isoform X3 [KO:K07296]
101432285  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
101411093  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101430574  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101432391  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101415901  UBC; polyubiquitin-C [KO:K08770]
101435185  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
101424098  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101419883  GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
101444041  glycerol kinase [KO:K00864] [EC:2.7.1.30]
101432806  GK2; LOW QUALITY PROTEIN: glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
101420957  AQP7; aquaporin-7 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
dnm00071  Fatty acid degradation
dnm00120  Primary bile acid biosynthesis
dnm00564  Glycerophospholipid metabolism
dnm04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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