KEGG   PATHWAY: efus04142
Entry
efus04142                   Pathway                                
Name
Lysosome - Eptesicus fuscus (big brown bat)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
efus04142  Lysosome
efus04142

Other DBs
GO: 0005764
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103283168  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
103283578  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
103284160  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
103284423  MEAK7; MTOR-associated protein MEAK7 [KO:K27947]
103284456  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
103284580  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
103284608  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
103284639  AP1G1; AP-1 complex subunit gamma-1 isoform X3 [KO:K12391]
103284940  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
103285077  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
103285529  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
103285747  [KO:K02155]
103285971  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
103286005  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
103286111  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
103286122  SLC17A5; sialin isoform X1 [KO:K12301]
103286134  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
103286271  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
103286431  CLTA; clathrin light chain A isoform X1 [KO:K04644]
103286627  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
103286822  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
103286865  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
103287017  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
103287115  CLTB; clathrin light chain B isoform X1 [KO:K04645]
103287330  [KO:K01365] [EC:3.4.22.15]
103287427  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
103287431  DMXL2; dmX-like protein 2 isoform X3 [KO:K24155]
103287637  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
103287713  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
103288007  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
103288177  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
103288216  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
103288295  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
103288389  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
103288696  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
103288704  AP3S1; AP-3 complex subunit sigma-1 isoform X2 [KO:K12399]
103288815  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
103288886  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X3 [KO:K12404]
103289106  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
103289316  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
103289392  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
103289454  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
103289588  PSAP; prosaposin [KO:K12382]
103290363  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
103290468  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
103290520  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
103290836  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
103290855  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
103290912  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
103290946  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
103290973  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
103291146  SORT1; sortilin isoform X1 [KO:K12388]
103291204  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
103291860  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
103291949  FUCA1; tissue alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
103292198  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
103292221  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
103292377  LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387]
103292396  CD63; CD63 antigen [KO:K06497]
103292499  GNS; N-acetylglucosamine-6-sulfatase isoform X1 [KO:K01137] [EC:3.1.6.14]
103293090  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
103293091  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
103293173  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
103293242  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
103293293  WDR7; WD repeat-containing protein 7 [KO:K24738]
103294100  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
103294275  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
103294360  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
103294523  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
103294585  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
103294773  PPT1; palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
103294810  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1 [KO:K03661]
103294957  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
103295094  MCOLN1; mucolipin-1 [KO:K04992]
103295132  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
103295460  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
103295764  GM2A; ganglioside GM2 activator [KO:K12383]
103296205  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
103296386  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
103296904  CD68; macrosialin [KO:K06501]
103296996  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
103297372  [KO:K01197] [EC:3.2.1.35]
103297485  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
103297755  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
103297882  [KO:K01365] [EC:3.4.22.15]
103297953  IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
103298188  AP1S2; AP-1 complex subunit sigma-2 isoform X2 [KO:K12394]
103298241  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
103298295  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X3 [KO:K12404]
103298369  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
103298614  HYAL2; hyaluronidase-2 isoform X1 [KO:K01197] [EC:3.2.1.35]
103298664  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
103298896  GBA1; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
103298976  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
103298978  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
103299285  LAMP2; LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 2 [KO:K06528]
103299706  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
103299804  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
103299898  CTNS; cystinosin isoform X1 [KO:K12386]
103300020  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
103300234  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
103300388  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X2 [KO:K02154]
103300409  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
103300450  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
103300459  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
103300557  [KO:K01197] [EC:3.2.1.35]
103300804  CLN3; battenin isoform X1 [KO:K12389]
103300895  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
103301011  DNASE2; LOW QUALITY PROTEIN: deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
103301069  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
103301096  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
103301125  AP1M2; AP-1 complex subunit mu-2 isoform X2 [KO:K12393]
103301502  AP1G2; AP-1 complex subunit gamma-like 2 isoform X2 [KO:K12391]
103301542  [KO:K01319] [EC:3.4.21.20]
103301543  [KO:K01319] [EC:3.4.21.20]
103301702  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
103301894  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
103302230  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
103302787  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
103302796  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
103302888  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
103303253  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
103303359  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
103303530  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
103303562  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
103303838  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
103304265  [KO:K01365] [EC:3.4.22.15]
103304836  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
103304954  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
103305213  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
103305219  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
103305336  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
114228115  [KO:K01365] [EC:3.4.22.15]
114231568  LITAFD; lITAF domain-containing protein isoform X1 [KO:K19363]
129147073  [KO:K01365] [EC:3.4.22.15]
129148347  AP3S2; AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
129149172  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
129151440  [KO:K01197] [EC:3.2.1.35]
129151930  [KO:K01365] [EC:3.4.22.15]
129152071  [KO:K06497]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Related
pathway
efus00511  Other glycan degradation
efus00531  Glycosaminoglycan degradation
efus04130  SNARE interactions in vesicular transport
efus04140  Autophagy - animal
efus04144  Endocytosis
KO pathway
ko04142   

DBGET integrated database retrieval system