KEGG PATHWAY: etl00260

PATHWAY: etl00260

Entry

etl00260                    Pathway

Name

Glycine, serine and threonine metabolism - Empidonax traillii (willow flycatcher)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

etl00260

Glycine, serine and threonine metabolism

Module

etl_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:etl00260]

etl_M00047

Creatine pathway [PATH:etl00260]

etl_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:etl00260]

etl_M00555

Betaine biosynthesis, choline => betaine [PATH:etl00260]

etl_M00621

Glycine cleavage system [PATH:etl00260]

etl_M00974

Betaine metabolism, animals, betaine => glycine [PATH:etl00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Empidonax traillii (willow flycatcher) [GN:etl]

Gene

114055219

GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]

114055396

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

114055813

[KO:K01754] [EC:4.3.1.19]

114056132

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

114056589

SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

114056825

[KO:K00274] [EC:1.4.3.4]

114056886

[KO:K00274] [EC:1.4.3.4]

114056907

DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

114056915

[KO:K00544] [EC:2.1.1.5]

114058667

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

114058670

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

114058694

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

114058777

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

114059122

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

114059938

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

114060369

[KO:K01620] [EC:4.1.2.48]

114060431

SRR; serine racemase [KO:K12235] [EC:5.1.1.18]

114060462

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

114060557

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

114061083

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

114061274

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

114062674

DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

114063957

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

114064512

AGXT; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

114065023

[KO:K01697] [EC:4.2.1.22]

114065959

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

114066149

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

114066419

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

114066474

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

114066770

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

114067807

[KO:K01697] [EC:4.2.1.22]

114069037

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

114070264

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

114070403

[KO:K20498] [EC:4.3.1.18]

114070705

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

114071205

[KO:K15789] [EC:1.1.1.103]

114071329

SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

114071929

PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

114073140

[KO:K00276] [EC:1.4.3.21]

114073141

[KO:K00276] [EC:1.4.3.21]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

C23135

(2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate

C23136

4-Amino-L-allothreonine

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721