KEGG   PATHWAY: fpoa03040
Entry
fpoa03040                   Pathway                                
Name
Spliceosome - Fusarium poae
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
fpoa03040  Spliceosome
fpoa03040

Other DBs
GO: 0005681
Organism
Fusarium poae [GN:fpoa]
Gene
FPOAC1_000166  ISY1; NineTeen Complex (NTC) component [KO:K12870]
FPOAC1_000376  SMD1; mRNA splicing protein smd1 [KO:K11087]
FPOAC1_000378  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
FPOAC1_000468  [KO:K12815] [EC:3.6.4.13]
FPOAC1_000478  LSM6; U4/U6-U5 snRNP complex subunit lsm6 [KO:K12625]
FPOAC1_000487  [KO:K12627]
FPOAC1_000489  [KO:K12662]
FPOAC1_000555  [KO:K12833]
FPOAC1_000635  [KO:K11094]
FPOAC1_000795  SMG1; Serine/threonine-protein kinase smg1 [KO:K11099]
FPOAC1_000884  HSPS1; Heat shock 70 kDa protein [KO:K03283]
FPOAC1_000936  CYP3; Peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
FPOAC1_000981  SSB1_2; Heat shock protein ssb1 [KO:K03283]
FPOAC1_001106  PRP5; pre-mRNA processing RNA-helicase [KO:K12811] [EC:3.6.4.13]
FPOAC1_001167  [KO:K11086]
FPOAC1_001276  [KO:K12826]
FPOAC1_001300  [KO:K12854] [EC:3.6.4.13]
FPOAC1_001389  [KO:K12880]
FPOAC1_001397  [KO:K12844]
FPOAC1_001398  CLF1; NineTeen Complex (NTC) component [KO:K12869]
FPOAC1_001436  PLRG1; Pleiotropic regulator 1 [KO:K12862]
FPOAC1_001485  [KO:K11098]
FPOAC1_001504  [KO:K12816]
FPOAC1_002655  [KO:K12817]
FPOAC1_002658  PRPF8; Pre-mRNA-processing-splicing factor 8 [KO:K12856]
FPOAC1_002776  [KO:K12857]
FPOAC1_002790  [KO:K12864]
FPOAC1_002837  [KO:K10599] [EC:2.3.2.27]
FPOAC1_002874  LSM3; U4/U6-U5 snRNP complex subunit lsm3 [KO:K12622]
FPOAC1_002883  [KO:K11097]
FPOAC1_002922  MNH1; Protein mago nashi [KO:K12877]
FPOAC1_002985  [KO:K12861]
FPOAC1_003081  SNU13; RNA binding protein snu13 [KO:K12845]
FPOAC1_003156  [KO:K12871]
FPOAC1_003171  [KO:K12840]
FPOAC1_003222  [KO:K11095]
FPOAC1_003340  [KO:K12855]
FPOAC1_003493  CDC28; Cyclin-dependent kinase catalytic subunit [KO:K12813] [EC:3.6.4.13]
FPOAC1_004481  [KO:K12839]
FPOAC1_004530  [KO:K12842]
FPOAC1_004786  SUB2; Suppressor of the cold-sensitive snRNP biogenesis mutant brr1-1 [KO:K12812] [EC:3.6.4.13]
FPOAC1_004909  CYP1; heme binding [KO:K12733] [EC:5.2.1.8]
FPOAC1_004950  [KO:K12832]
FPOAC1_005050  SLU7; mRNA splicing protein [KO:K12819]
FPOAC1_005090  LSM7; Sm-like protein lsm7 [KO:K12626]
FPOAC1_005094  [KO:K12825]
FPOAC1_005134  SLT11; Pre-mRNA-splicing factor slt11 [KO:K12872]
FPOAC1_006579  DBP2; ATP-dependent RNA helicase dbp2 [KO:K12823] [EC:3.6.4.13]
FPOAC1_006743  MSP41; Pre-mRNA-splicing factor syf1 [KO:K12867]
FPOAC1_006751  [KO:K12843]
FPOAC1_006780  [KO:K12829]
FPOAC1_007785  [KO:K12876]
FPOAC1_007898  [KO:K12818] [EC:3.6.4.13]
FPOAC1_008087  [KO:K12879]
FPOAC1_008154  CWC15; complexed with cef1p [KO:K12863]
FPOAC1_008174  [KO:K12883]
FPOAC1_008243  [KO:K12878]
FPOAC1_008244  [KO:K12874]
FPOAC1_008363  [KO:K12623]
FPOAC1_008379  LEA1; U2 snRNP complex subunit [KO:K11092]
FPOAC1_008817  [KO:K12827]
FPOAC1_008818  FAL1; RNA helicase [KO:K13025] [EC:3.6.4.13]
FPOAC1_008928  SMD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
FPOAC1_009090  PRP45; mRNA splicing protein [KO:K06063]
FPOAC1_009263  [KO:K11984]
FPOAC1_009410  [KO:K12849]
FPOAC1_009475  PRP43; DEAH-box ATP-dependent RNA helicase prp43 [KO:K12820] [EC:3.6.4.13]
FPOAC1_009557  [KO:K12881]
FPOAC1_010433  [KO:K11093]
FPOAC1_010476  SYF2; pre-mRNA-splicing factor syf2 [KO:K12868]
FPOAC1_010530  [KO:K12847]
FPOAC1_010560  LSM5; RNA-binding protein lsm5 [KO:K12624]
FPOAC1_010590  PRP28; mRNA splicing protein prp28 [KO:K12858] [EC:3.6.4.13]
FPOAC1_010598  [KO:K12881]
FPOAC1_010604  [KO:K12836]
FPOAC1_010683  [KO:K12873]
FPOAC1_010751  TXNL4A; Thioredoxin-like 4A [KO:K12859]
FPOAC1_010776  SMD2; mRNA splicing protein [KO:K11096]
FPOAC1_010809  [KO:K12837]
FPOAC1_010811  [KO:K12828]
FPOAC1_010864  [KO:K12821]
FPOAC1_011021  RSE1; pre-mRNA-splicing factor rse1 [KO:K12830]
FPOAC1_011110  [KO:K12882]
FPOAC1_011127  [KO:K12831]
FPOAC1_011831  CEF1; Pre-mRNA-splicing factor cef1 [KO:K12860]
FPOAC1_012372  [KO:K12852]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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