KEGG   PATHWAY: gvr03320
Entry
gvr03320                    Pathway                                
Name
PPAR signaling pathway - Galeopterus variegatus (Sunda flying lemur)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
gvr03320  PPAR signaling pathway
gvr03320

Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103582177  [KO:K01641] [EC:2.3.3.10]
103582326  [KO:K08745] [EC:6.2.1.-]
103585191  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
103585343  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103585646  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
103585805  FABP7; fatty acid-binding protein, brain [KO:K08756]
103585831  SLC27A2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103587697  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
103587704  ACSL5; LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
103588225  [KO:K07431] [EC:1.14.14.139]
103588317  CD36; platelet glycoprotein 4 [KO:K06259]
103588662  ACADL; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
103588802  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
103589579  PLTP; phospholipid transfer protein isoform X1 [KO:K08761]
103589966  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
103590057  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
103590171  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
103590226  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
103590382  GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
103590613  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
103590931  UCP1; mitochondrial brown fat uncoupling protein 1 isoform X1 [KO:K08769]
103590981  [KO:K01596] [EC:4.1.1.32]
103591311  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
103591460  EHHADH; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
103591675  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
103591747  [KO:K00489] [EC:1.14.14.23]
103591776  UBC; polyubiquitin-C [KO:K08770]
103591952  ACSBG1; long-chain-fatty-acid--CoA ligase ACSBG1 [KO:K15013] [EC:6.2.1.3]
103592095  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
103592494  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
103592593  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
103592701  ME1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
103592938  ACSBG2; long-chain-fatty-acid--CoA ligase ACSBG2 [KO:K15013] [EC:6.2.1.3]
103592948  [KO:K15013] [EC:6.2.1.3]
103593550  ACOX2; peroxisomal acyl-coenzyme A oxidase 2 [KO:K10214] [EC:1.17.99.3]
103594796  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
103594997  HMGCS1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
103595076  FABP2; fatty acid-binding protein, intestinal [KO:K08751]
103595262  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
103595548  SLC27A5; bile acyl-CoA synthetase [KO:K08748] [EC:6.2.1.7]
103595764  SLC27A4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
103595947  SCP2; non-specific lipid-transfer protein isoform X1 [KO:K08764] [EC:2.3.1.176]
103596116  [KO:K00864] [EC:2.7.1.30]
103596239  PLIN2; perilipin-2 [KO:K17284]
103596547  APOA2; apolipoprotein A-II [KO:K08758]
103596946  FABP4; fatty acid-binding protein, adipocyte [KO:K08753]
103597087  FABP3; fatty acid-binding protein, heart [KO:K08752]
103597703  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
103597756  FABP5; fatty acid-binding protein, epidermal [KO:K08754]
103597936  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
103598680  ADIPOQ; adiponectin [KO:K07296]
103599771  ANGPTL4; angiopoietin-related protein 4 [KO:K08767]
103600243  [KO:K00488] [EC:1.14.15.15]
103601111  DBI; acyl-CoA-binding protein [KO:K08762]
103601179  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103602119  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
103602586  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
103602685  FABP6; gastrotropin [KO:K08755]
103602728  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
103604810  FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
103605279  [KO:K00864] [EC:2.7.1.30]
103605585  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
103606367  AQP7; aquaporin-7 [KO:K08771]
103606571  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
103606714  SLC27A6; long-chain fatty acid transport protein 6 [KO:K08749]
103607177  APOA1; apolipoprotein A-I [KO:K08757]
103607180  APOC3; apolipoprotein C-III [KO:K08759]
103607349  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
103607446  APOA5; apolipoprotein A-V [KO:K09025]
103608067  PLIN5; perilipin-5 [KO:K20255]
103608068  PLIN4; perilipin-4 [KO:K20254]
103608611  [KO:K08762]
103609293  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
103609385  FABP1; fatty acid-binding protein, liver [KO:K08750]
103609979  ME3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
103610223  [KO:K01388] [EC:3.4.24.7]
103610673  HMGCS2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:2.3.3.10]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
gvr00071  Fatty acid degradation
gvr00120  Primary bile acid biosynthesis
gvr00564  Glycerophospholipid metabolism
gvr04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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