KEGG   PATHWAY: hgl00830
Entry
hgl00830                    Pathway                                
Name
Retinol metabolism - Heterocephalus glaber (naked mole-rat)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hgl00830  Retinol metabolism
hgl00830

Other DBs
GO: 0006776
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101724039  Bco1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]
101717353  Adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101707720  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101707915  Dhrs3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
101708169  Dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
101716890  Dhrs9; dehydrogenase/reductase 9 [KO:K11149] [EC:1.1.-.-]
101710179  Rdh8; retinol dehydrogenase 8 (all-trans) [KO:K11150] [EC:1.1.1.-]
101724742  Rdh10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
101716314  Rdh11; retinol dehydrogenase 11 (all-trans/9-cis/11-cis) [KO:K11152] [EC:1.1.1.300]
101715642  Rdh12; retinol dehydrogenase 12 (all-trans/9-cis/11-cis) [KO:K11153] [EC:1.1.1.300]
101716026  Rdh13; retinol dehydrogenase 13 [KO:K11161] [EC:1.1.1.300]
101698175  Rdh16; retinol dehydrogenase 16 (all-trans) [KO:K11154] [EC:1.1.1.-]
101723971  Sdr16c5; short chain dehydrogenase/reductase family 16C member 5 [KO:K15734] [EC:1.1.1.105]
101699287  Hsd17b6; hydroxysteroid 17-beta dehydrogenase 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
101722664  Lrat; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) [KO:K00678] [EC:2.3.1.135]
101723650  Dgat1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
101701856  Awat2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
101719226  Pnpla4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]
101716560  Rpe65; RPE65, retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
101701578  Rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
101710340  aldehyde oxidase 2-like [KO:K00157] [EC:1.2.3.1]
101722324  Aox4; aldehyde oxidase-like [KO:K00157] [EC:1.2.3.1]
101722898  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
101699741  Aldh1a2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]
101696832  retinal dehydrogenase 1-like [KO:K07249] [EC:1.2.1.36]
101697212  retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
101705109  aldehyde dehydrogenase, cytosolic 2-like [KO:K07249] [EC:1.2.1.36]
101706446  Aldh1a1; aldehyde dehydrogenase 1 family member A1 [KO:K07249] [EC:1.2.1.36]
101700669  Aldh1a3; aldehyde dehydrogenase 1 family member A3 [KO:K07249] [EC:1.2.1.36]
101699044  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
101714280  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
101708363  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
101707509  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101706775  cytochrome P450 2A3 [KO:K07411] [EC:1.14.14.1]
101707867  cytochrome P450 2A3 [KO:K07411] [EC:1.14.14.1]
101708686  cytochrome P450 2A3 [KO:K07411] [EC:1.14.14.1]
101713256  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
101700457  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
101708592  cytochrome P450 2C55 [KO:K07413] [EC:1.14.14.1]
101710990  cytochrome P450 2C5 [KO:K07413] [EC:1.14.14.1]
101700677  cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]
101700489  cytochrome P450 3A9 [KO:K07424] [EC:1.14.14.1]
101698313  cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
101696405  cytochrome P450 4A4-like [KO:K07425] [EC:1.14.14.80]
101699948  cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
101700306  cytochrome P450 4A4-like [KO:K07425] [EC:1.14.14.80]
101707823  Ugt1a6; UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
101713955  Ugt2a1; UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
101712271  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101711049  UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]
101711920  UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
101698281  UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
101710483  UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]
101699331  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
101700403  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
101722538  UDP-glucuronosyltransferase 1-9 [KO:K00699] [EC:2.4.1.17]
101697239  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
101708622  Retsat; retinol saturase [KO:K09516] [EC:1.3.99.23]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
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