KEGG PATHWAY: hgl00830

PATHWAY: hgl00830

Entry

hgl00830                    Pathway

Name

Retinol metabolism - Heterocephalus glaber (naked mole-rat)

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

hgl00830

Retinol metabolism

Other DBs

GO:

0006776

Organism

Heterocephalus glaber (naked mole-rat) [GN:hgl]

Gene

101696405

[KO:K07425] [EC:1.14.14.80]

101696832

[KO:K07249] [EC:1.2.1.36]

101697212

[KO:K07249] [EC:1.2.1.36]

101697239

[KO:K00699] [EC:2.4.1.17]

101698175

Rdh16; retinol dehydrogenase 16 (all-trans) [KO:K11154] [EC:1.1.1.-]

101698281

[KO:K00699] [EC:2.4.1.17]

101698313

[KO:K07423] [EC:1.14.14.-]

101699044

[KO:K07437] [EC:1.14.14.-]

101699287

Hsd17b6; hydroxysteroid 17-beta dehydrogenase 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]

101699331

[KO:K00699] [EC:2.4.1.17]

101699741

Aldh1a2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]

101699948

[KO:K07425] [EC:1.14.14.80]

101700306

[KO:K07425] [EC:1.14.14.80]

101700403

[KO:K00699] [EC:2.4.1.17]

101700457

[KO:K07412] [EC:1.14.14.1]

101700489

[KO:K07424] [EC:1.14.14.1]

101700669

Aldh1a3; aldehyde dehydrogenase 1 family member A3 [KO:K07249] [EC:1.2.1.36]

101700677

[KO:K07420] [EC:1.14.14.1]

101701578

Rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]

101701856

Awat2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]

101705109

[KO:K07249] [EC:1.2.1.36]

101706446

Aldh1a1; aldehyde dehydrogenase 1 family member A1 [KO:K07249] [EC:1.2.1.36]

101706775

[KO:K07411] [EC:1.14.14.1]

101707720

[KO:K00121] [EC:1.1.1.284 1.1.1.1]

101707823

Ugt1a6; UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]

101707867

[KO:K07411] [EC:1.14.14.1]

101707915

Dhrs3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]

101708169

Dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]

101708363

[KO:K12665] [EC:1.14.14.-]

101708592

[KO:K07413] [EC:1.14.14.1]

101708622

Retsat; retinol saturase [KO:K09516] [EC:1.3.99.23]

101708686

[KO:K07411] [EC:1.14.14.1]

101710179

Rdh8; retinol dehydrogenase 8 (all-trans) [KO:K11150] [EC:1.1.1.-]

101710340

[KO:K00157] [EC:1.2.3.1]

101710483

[KO:K00699] [EC:2.4.1.17]

101710990

[KO:K07413] [EC:1.14.14.1]

101711049

[KO:K00699] [EC:2.4.1.17]

101711920

[KO:K00699] [EC:2.4.1.17]

101712271

[KO:K00699] [EC:2.4.1.17]

101713256

[KO:K07412] [EC:1.14.14.1]

101713955

Ugt2a1; UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]

101714280

[KO:K12664] [EC:1.14.14.-]

101715642

Rdh12; retinol dehydrogenase 12 (all-trans/9-cis/11-cis) [KO:K11153] [EC:1.1.1.300]

101716026

Rdh13; retinol dehydrogenase 13 [KO:K11161] [EC:1.1.1.300]

101716314

Rdh11; retinol dehydrogenase 11 (all-trans/9-cis/11-cis) [KO:K11152] [EC:1.1.1.300]

101716560

Rpe65; RPE65, retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]

101716890

Dhrs9; dehydrogenase/reductase 9 [KO:K11149] [EC:1.1.-.-]

101717353

Adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]

101719226

Pnpla4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]

101722324

Aox4; aldehyde oxidase-like [KO:K00157] [EC:1.2.3.1]

101722538

[KO:K00699] [EC:2.4.1.17]

101722664

Lrat; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) [KO:K00678] [EC:2.3.1.135]

101722898

Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]

101723650

Dgat1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]

101723971

Sdr16c5; short chain dehydrogenase/reductase family 16C member 5 [KO:K15734] [EC:1.1.1.105]

101724039

Bco1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]

101724742

Rdh10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]

Compound

C00376

Retinal

C00473

Retinol

C00777

Retinoate

C00778

Rhodopsin

C00899

11-cis-Retinol

C02075

Retinyl ester

C02094

beta-Carotene

C02110

11-cis-Retinal

C02588

Retinyl palmitate

C03455

11-cis-Retinyl palmitate

C05914

Bathorhodopsin

C05915

Lumirhodopsin

C05916

Metarhodopsin

C05917

Iodopsin

C11061

all-trans-Retinoyl-beta-glucuronide

C15492

all-trans-13,14-Dihydroretinol

C15493

9-cis-Retinoic acid

C16677

all-trans-4-Hydroxyretinoic acid

C16678

all-trans-4-Oxoretinoic acid

C16679

all-trans-18-Hydroxyretinoic acid

C16680

all-trans-5,6-Epoxyretinoic acid

C16681

9-cis-Retinal

C16682

9-cis-Retinol

C16683

4-Oxoretinol

C21797

all-trans-3,4-Didehydroretinol

Reference

PMID:16968212

Authors

Travis GH, Golczak M, Moise AR, Palczewski K.

Title

Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.

Journal

Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225

Reference

PMID:17618621

Authors

Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.

Title

A novel cone visual cycle in the cone-dominated retina.

Journal

Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003

Reference

PMID:11093772

Authors

Marill J, Cresteil T, Lanotte M, Chabot GG.

Title

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

Journal

Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341

Reference

PMID:17893666

Authors

Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.

Title

Molecular and metabolic retinoid pathways in the human ocular surface.

Journal

Mol Vis 13:1641-50 (2007)

Reference

PMID:16688755

Authors

Blomhoff R, Blomhoff HK.

Title

Overview of retinoid metabolism and function.

Journal

J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242

Reference

PMID:16428379

Authors

Liden M, Eriksson U.

Title

Understanding retinol metabolism: structure and function of retinol dehydrogenases.

Journal

J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200

KO pathway

ko00830

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