Entry Name Wnt signaling pathway - Hippoglossus hippoglossus (Atlantic halibut)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Hippoglossus hippoglossus (Atlantic halibut) [GN:
hhip ]
Gene 117752050 dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
117753439 tcf7l2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491 ]
117754035 bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162 ]
117755603 daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
117755975 tle3b; transducin-like enhancer protein 3-B isoform X1 [KO:K04497 ]
117757328 lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309 ]
117759368 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
117759780 tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508 ]
117760718 tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497 ]
117760864 apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
117761742 wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572 ]
117762744 lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
117763118 tle3a; transducin-like enhancer protein 3-A isoform X1 [KO:K04497 ]
117764083 prickle3; prickle planar cell polarity protein 3 isoform X1 [KO:K04511 ]
117764172 ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504 ]
117764347 nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
117765696 prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345 ] [EC:2.7.11.11 ]
117768514 camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
117769018 fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362 ]
117769260 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
117770333 nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
117770808 camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
117771112 si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
117771319 tcf7l1a; LOW QUALITY PROTEIN: transcription factor 7-like 1-A [KO:K04490 ]
117774128 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
117774683 camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
117774691 serpinf1; pigment epithelium-derived factor isoform X1 [KO:K19614 ]
117775463 camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
117776433 nkd2b; protein naked cuticle homolog 2-like isoform X1 [KO:K03213 ]
117776813 wnt4b; wingless-type MMTV integration site family, member 4b isoform X1 [KO:K00408 ]
117778808 nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
117778900 chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494 ] [EC:5.6.2.-]
117779173 camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
