KEGG   PATHWAY: hhip04010
Entry
hhip04010                   Pathway                                
Name
MAPK signaling pathway - Hippoglossus hippoglossus (Atlantic halibut)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hhip04010  MAPK signaling pathway
hhip04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Hippoglossus hippoglossus (Atlantic halibut) [GN:hhip]
Gene
117751798  [KO:K04419] [EC:2.7.11.25]
117751799  rela; transcription factor p65 isoform X1 [KO:K04735]
117752065  tp53; cellular tumor antigen p53 [KO:K04451]
117752252  [KO:K04348] [EC:3.1.3.16]
117752454  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117752515  [KO:K04466] [EC:2.7.11.25]
117752531  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
117752542  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117752579  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
117752728  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
117752732  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117752733  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117752778  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
117752832  [KO:K04392]
117752932  ngfrb; nerve growth factor receptor b [KO:K02583]
117752970  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117752994  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
117753178  [KO:K04467] [EC:2.7.11.10]
117753249  [KO:K07861]
117753335  fgf21; fibroblast growth factor 21 [KO:K22429]
117753462  [KO:K04380]
117753557  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117753648  [KO:K04361] [EC:2.7.10.1]
117753707  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117753770  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
117753802  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
117753812  map3k22; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
117753979  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
117753981  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117754053  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
117754056  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117754084  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
117754467  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117754491  tgfbr2l; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117754585  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117754645  [KO:K05085] [EC:2.7.10.1]
117754890  rras2; ras-related protein R-Ras2 [KO:K07830]
117754920  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
117754995  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
117755309  [KO:K04407] [EC:2.7.11.1]
117755312  [KO:K04386]
117755438  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117755449  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117755596  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
117755629  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117755641  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117755691  [KO:K04402]
117755759  pgfb; placenta growth factor [KO:K16859]
117755762  [KO:K04350]
117755916  [KO:K04453]
117755965  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117755988  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
117755991  [KO:K04427] [EC:2.7.11.25]
117756091  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117756116  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
117756430  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
117756602  efna2a; ephrin-A2 isoform X1 [KO:K05462]
117756644  tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
117756645  fosaa; proto-oncogene c-Fos isoform X1 [KO:K04379]
117756654  [KO:K04410] [EC:2.7.11.1]
117756659  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117756660  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
117756999  fgf23; fibroblast growth factor 23 [KO:K22428]
117757000  [KO:K04358]
117757017  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
117757053  [KO:K07836]
117757155  igf1; insulin-like growth factor I [KO:K05459]
117757218  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
117757219  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
117757226  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117757227  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
117757229  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117757377  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117757424  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
117757425  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117757547  [KO:K05461]
117757643  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
117757652  ntf3; neurotrophin-3 [KO:K04356]
117757710  [KO:K25416]
117758191  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117758243  [KO:K04379]
117758245  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
117758302  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117758341  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117758516  [KO:K13377]
117758535  max; protein max isoform X1 [KO:K04453]
117758538  [KO:K04349]
117758563  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
117758625  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
117758678  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
117758896  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117759004  [KO:K05090] [EC:2.7.10.1]
117759005  [KO:K05090] [EC:2.7.10.1]
117759349  si:ch211-79m20.1; putative mediator of RNA polymerase II transcription subunit 26 isoform X1 [KO:K17386]
117759368  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117759376  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117759402  fgf7; fibroblast growth factor 7 [KO:K04358]
117759410  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117759435  [KO:K04867]
117759443  fgf3; fibroblast growth factor 3 [KO:K04358]
117759446  fgf19; fibroblast growth factor 19 [KO:K22603]
117759451  fgf4; fibroblast growth factor 4 [KO:K04358]
117759554  [KO:K04373] [EC:2.7.11.1]
117759561  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117759571  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
117759678  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117759682  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117759701  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117759730  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
117759851  [KO:K05462]
117759920  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117759963  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
117760026  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117760139  jun; transcription factor AP-1 [KO:K04448]
117760140  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117760173  [KO:K04852]
117760248  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117760289  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
117760333  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
117760569  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117760651  [KO:K04402]
117760658  fgf22; fibroblast growth factor 22 [KO:K04358]
117760664  [KO:K04866]
117760686  [KO:K16342] [EC:3.1.1.4]
117760712  jund; transcription factor jun-D [KO:K04449]
117760725  insrb; LOW QUALITY PROTEIN: insulin receptor b [KO:K04527] [EC:2.7.10.1]
117760776  [KO:K25415]
117760944  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
117761056  [KO:K04444] [EC:2.7.11.1]
117761064  ngfb; nerve growth factor [KO:K02582]
117761075  [KO:K04393]
117761137  [KO:K04859]
117761147  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117761201  [KO:K04465]
117761286  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
117761319  [KO:K04353]
117761329  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
117761377  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
117761402  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
117761588  mych; myelocytomatosis oncogene homolog [KO:K04377]
117761619  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
117761777  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
117761905  [KO:K04423] [EC:2.7.11.25]
117761949  [KO:K04359]
117761975  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
117762104  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117762112  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
117762118  cacna2d2a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
117762186  [KO:K04411]
117762214  angpt4; angiopoietin-4 [KO:K05465]
117762324  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117762514  [KO:K04868]
117762555  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
117762627  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117762628  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
117762729  [KO:K04434]
117762737  [KO:K04858]
117762738  [KO:K05460]
117762987  kras; GTPase KRas isoform X1 [KO:K07827]
117763003  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117763078  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117763104  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117763124  igf2b; insulin-like growth factor 2b isoform X1 [KO:K13769]
117763157  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
117763366  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117763451  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117763487  kitlga; kit ligand a isoform X1 [KO:K05461]
117763532  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117763559  [KO:K03099]
117763573  [KO:K02833]
117763751  [KO:K22428]
117763752  [KO:K04358]
117763797  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117763822  [KO:K17333]
117764022  ngfa; neurotrophin-7 [KO:K02582]
117764057  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
117764060  [KO:K04378]
117764087  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117764120  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
117764155  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117764159  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117764251  [KO:K04353]
117764306  elk1; ETS domain-containing protein Elk-3 [KO:K04375]
117764431  [KO:K04393]
117764489  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
117764522  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
117764565  cacna2d3a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
117764596  [KO:K04857]
117764645  [KO:K18019] [EC:3.1.3.48]
117764661  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
117764690  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
117764774  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
117764779  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117764861  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
117764912  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
117764914  [KO:K19662] [EC:2.7.11.13]
117765094  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117765129  [KO:K04856]
117765172  [KO:K05459]
117765234  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
117765247  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
117765330  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117765385  flna; filamin-A isoform X1 [KO:K04437]
117765388  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117765414  [KO:K03283]
117765415  [KO:K03283]
117765696  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
117765705  [KO:K04392]
117765826  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
117765891  [KO:K19662] [EC:2.7.11.13]
117765894  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117765921  si:ch73-374l24.1; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
117765924  [KO:K04870]
117765927  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
117765936  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
117765992  [KO:K04429] [EC:2.7.11.1]
117766000  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117766006  [KO:K04869]
117766010  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
117766178  dusp3b; dual specificity protein phosphatase 3b [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117766200  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
117766311  [KO:K04433] [EC:2.7.12.2]
117766449  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
117766492  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
117766501  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117766506  [KO:K04347]
117766567  atf4b; activating transcription factor 4b [KO:K04374]
117766571  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
117766665  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
117766714  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
117766716  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117766747  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117766775  zgc:55558; GTPase HRas [KO:K07827]
117766821  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
117766932  [KO:K16342] [EC:3.1.1.4]
117766933  [KO:K16342] [EC:3.1.1.4]
117766934  [KO:K16342] [EC:3.1.1.4]
117766935  [KO:K16342] [EC:3.1.1.4]
117766955  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
117766970  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
117766971  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
117767037  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
117767434  fgf5; fibroblast growth factor 5 [KO:K04358]
117767462  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
117767472  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
117767543  [KO:K04519]
117767564  [KO:K04358]
117767593  efna5b; ephrin-A5b isoform X1 [KO:K05462]
117767647  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
117767714  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117767735  [KO:K05452]
117767784  [KO:K04352]
117767807  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
117767832  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117767837  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117767894  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117767997  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117768005  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117768014  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117768221  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
117768344  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
117768440  [KO:K09784]
117768544  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
117768571  [KO:K04348] [EC:3.1.3.16]
117768576  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
117768812  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
117768814  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117768936  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117768955  [KO:K02187] [EC:3.4.22.56]
117768956  [KO:K02187] [EC:3.4.22.56]
117769004  fgf20b; fibroblast growth factor 20b [KO:K04358]
117769009  fgf2; fibroblast growth factor 2 [KO:K18497]
117769079  fgf16; fibroblast growth factor 16 [KO:K04358]
117769118  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117769119  [KO:K05090] [EC:2.7.10.1]
117769183  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117769240  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
117769257  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117769260  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117769264  insb; preproinsulin b [KO:K04526]
117769281  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
117769340  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
117769534  egf; pro-epidermal growth factor [KO:K04357]
117769573  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
117769592  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117769623  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
117769640  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
117769652  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
117769667  cd40lg; CD40 ligand isoform X1 [KO:K04389]
117769739  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117769843  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117769874  [KO:K04358]
117770087  angpt1; angiopoietin-1 [KO:K05465]
117770168  stk3; serine/threonine-protein kinase 3 [KO:K04412]
117770218  angpt2b; angiopoietin-2b [KO:K05466]
117770333  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
117770486  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117770501  efna1a; ephrin-A1a isoform X1 [KO:K05462]
117770545  stmn1a; stathmin 1a [KO:K04381]
117770664  efna3a; ephrin-A3 [KO:K05462]
117770794  fgf8b; fibroblast growth factor 8b [KO:K04358]
117770903  [KO:K04388] [EC:2.7.11.30]
117770929  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
117771050  [KO:K04873]
117771052  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a isoform X1 [KO:K04872]
117771060  [KO:K04871]
117771066  [KO:K04393]
117771220  dusp4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117771231  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117771243  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117771259  [KO:K03173] [EC:2.3.2.27]
117771314  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
117771326  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
117771428  [KO:K04448]
117771429  [KO:K04448]
117771643  crkl; crk-like protein [KO:K04438]
117771676  [KO:K03283]
117771815  taok3b; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
117771866  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
117771914  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
117771988  [KO:K05462]
117772061  [KO:K04455]
117772062  [KO:K04402]
117772065  [KO:K04402]
117772097  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
117772103  fgf10a; fibroblast growth factor 10a [KO:K04358]
117772227  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117772243  cacna1bb; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
117772327  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117772376  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
117772380  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
117772384  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
117772455  [KO:K04723]
117772467  arrb1; beta-arrestin-1 [KO:K04439]
117772532  [KO:K08052]
117772555  crk; adapter molecule crk [KO:K04438]
117772640  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
117772670  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117772871  relb; transcription factor p65 isoform X1 [KO:K09253]
117772924  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
117773035  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117773159  [KO:K04468] [EC:2.7.11.24]
117773192  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
117773302  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
117773375  rasa2; ras GTPase-activating protein 2 [KO:K08053]
117773414  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
117773835  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117773955  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
117774028  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
117774061  vegfc; vascular endothelial growth factor C [KO:K05449]
117774108  hspb1; heat shock protein beta-1 [KO:K04455]
117774128  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117774132  [KO:K03283]
117774134  [KO:K03283]
117774371  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117774515  [KO:K04456] [EC:2.7.11.1]
117774549  [KO:K04438]
117774639  ins; insulin [KO:K04526]
117774692  [KO:K04439]
117774933  [KO:K18496]
117775042  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
117775137  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117775148  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
117775231  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117775266  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
117775293  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
117775336  [KO:K04406] [EC:2.7.11.1]
117775348  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
117775425  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117775521  srfb; serum response factor b isoform X1 [KO:K04378]
117775755  [KO:K04469]
117775765  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
117775780  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117775794  [KO:K04469]
117775918  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
117775975  [KO:K04467] [EC:2.7.11.10]
117775982  angpt2a; angiopoietin-2a [KO:K05466]
117776226  [KO:K04381]
117776253  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
117776392  [KO:K04407] [EC:2.7.11.1]
117776557  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
117776812  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117776839  cdc42l; cell division cycle 42, like [KO:K04393]
117776946  [KO:K05085] [EC:2.7.10.1]
117777032  efna1b; ephrin-A1b [KO:K05462]
117777068  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
117777108  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
117777133  efna3b; ephrin-A3b [KO:K05462]
117777178  [KO:K04388] [EC:2.7.11.30]
117777200  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
117777201  [KO:K04446]
117777206  nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
117777263  [KO:K04381]
117777271  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
117777309  [KO:K05449]
117777363  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117777364  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
117777402  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117777712  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117777734  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
117777765  [KO:K04865]
117777824  [KO:K04424] [EC:2.7.11.25]
117778000  [KO:K04449]
117778062  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117778171  [KO:K04852]
117778239  [KO:K04448]
117778664  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
117778766  [KO:K25415]
117778848  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
117778862  [KO:K25414]
117778886  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
117779283  [KO:K12361]
117779285  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117779437  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
hhip04070  Phosphatidylinositol signaling system
hhip04110  Cell cycle
hhip04115  p53 signaling pathway
hhip04210  Apoptosis
hhip04310  Wnt signaling pathway
KO pathway
ko04010   

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