KEGG   Homo sapiens (human): 8878
Entry
8878              CDS       T01001                                 
Symbol
SQSTM1, A170, DMRV, EBIAP, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B
Name
(RefSeq) sequestosome 1
  KO
K14381  sequestosome 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04217  Necroptosis
hsa04218  Cellular senescence
hsa04380  Osteoclast differentiation
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06527  Necroptosis
nt06532  Autophagy
nt06536  Mitophagy
  Element
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01650  SQSTM1 regulation of RIPK1/3
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Disease
H00437  Paget disease of bone
H00594  Distal myopathy
H02342  Frontotemporal dementia and amyotrophic lateral sclerosis
H02586  Distal myopathy with rimmed vacuoles
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    8878 (SQSTM1)
   04137 Mitophagy - animal
    8878 (SQSTM1)
  09143 Cell growth and death
   04217 Necroptosis
    8878 (SQSTM1)
   04218 Cellular senescence
    8878 (SQSTM1)
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    8878 (SQSTM1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    8878 (SQSTM1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    8878 (SQSTM1)
   05022 Pathways of neurodegeneration - multiple diseases
    8878 (SQSTM1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    8878 (SQSTM1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8878 (SQSTM1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    8878 (SQSTM1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8878 (SQSTM1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Cargo receptors
    8878 (SQSTM1)
  Pexophagy
    8878 (SQSTM1)
  Aggrephagy
    8878 (SQSTM1)
  Xenophagy
    8878 (SQSTM1)
  ER-phagy
   ER-phagy recepters
    8878 (SQSTM1)
  Other autophagy associated proteins
   Midbophagy
    8878 (SQSTM1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    8878 (SQSTM1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   8878 (SQSTM1)
SSDB
Motif
Pfam: UBA_5 PB1 ZZ
Other DBs
NCBI-GeneID: 8878
NCBI-ProteinID: NP_003891
OMIM: 601530
HGNC: 11280
Ensembl: ENSG00000161011
UniProt: Q13501
Structure
LinkDB
Position
5:179806393..179838078
AA seq 440 aa
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRP
GGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRN
MVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNV
GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV
EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPE
SEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTK
NYDIGAALDTIQYSKHPPPL
NT seq 1323 nt   +upstreamnt  +downstreamnt
atggcgtcgctcaccgtgaaggcctaccttctgggcaaggaggacgcggcgcgcgagatt
cgccgcttcagcttctgctgcagccccgagcctgaggcggaagccgaggctgcggcgggt
ccgggaccctgcgagcggctgctgagccgggtggccgccctgttccccgcgctgcggcct
ggcggcttccaggcgcactaccgcgatgaggacggggacttggttgccttttccagtgac
gaggaattgacaatggccatgtcctacgtgaaggatgacatcttccgaatctacattaaa
gagaaaaaagagtgccggcgggaccaccgcccaccgtgtgctcaggaggcgccccgcaac
atggtgcaccccaatgtgatctgcgatggctgcaatgggcctgtggtaggaacccgctac
aagtgcagcgtctgcccagactacgacttgtgtagcgtctgcgagggaaagggcttgcac
cgggggcacaccaagctcgcattccccagccccttcgggcacctgtctgagggcttctcg
cacagccgctggctccggaaggtgaaacacggacacttcgggtggccaggatgggaaatg
ggtccaccaggaaactggagcccacgtcctcctcgtgcaggggaggcccgccctggcccc
acggcagaatcagcttctggtccatcggaggatccgagtgtgaatttcctgaagaacgtt
ggggagagtgtggcagctgcccttagccctctgggcattgaagttgatatcgatgtggag
cacggagggaaaagaagccgcctgacccccgtctctccagagagttccagcacagaggag
aagagcagctcacagccaagcagctgctgctctgaccccagcaagccgggtgggaatgtt
gagggcgccacgcagtctctggcggagcagatgaggaagatcgccttggagtccgagggg
cgccctgaggaacagatggagtcggataactgttcaggaggagatgatgactggacccat
ctgtcttcaaaagaagtggacccgtctacaggtgaactccagtccctacagatgccagaa
tccgaagggccaagctctctggacccctcccaggagggacccacagggctgaaggaagct
gccttgtacccacatctcccgccagaggctgacccgcggctgattgagtccctctcccag
atgctgtccatgggcttctctgatgaaggcggctggctcaccaggctcctgcagaccaag
aactatgacatcggagcggctctggacaccatccagtattcaaagcatcccccgccgttg
tga

KEGG   Homo sapiens (human): 10133
Entry
10133             CDS       T01001                                 
Symbol
OPTN, ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Name
(RefSeq) optineurin
  KO
K19946  optineurin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N01137  PINK-Parkin-mediated autophagosome formation
N01138  Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00612  Primary open angle glaucoma
H02877  Glaucoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    10133 (OPTN)
   04137 Mitophagy - animal
    10133 (OPTN)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    10133 (OPTN)
   05022 Pathways of neurodegeneration - multiple diseases
    10133 (OPTN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10133 (OPTN)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    10133 (OPTN)
 Protein recycling
  Rab GTPases and associated proteins
   Other Rab GTPase associated proteins
    10133 (OPTN)
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    10133 (OPTN)
  Xenophagy
   Cargo receptors
    10133 (OPTN)
SSDB
Motif
Pfam: CC2-LZ NEMO zf_C2H2_10 FAZ1_C PDC10_C
Other DBs
NCBI-GeneID: 10133
NCBI-ProteinID: NP_001008212
OMIM: 602432
HGNC: 17142
Ensembl: ENSG00000123240
UniProt: Q96CV9
Structure
LinkDB
Position
10:13100082..13138308
AA seq 577 aa
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL
NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER
SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE
IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL
REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE
ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK
LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR
AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA
AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE
DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
NT seq 1734 nt   +upstreamnt  +downstreamnt
atgtcccatcaacctctcagctgcctcactgaaaaggaggacagccccagtgaaagcaca
ggaaatggacccccccacctggcccacccaaacctggacacgtttaccccggaggagctg
ctgcagcagatgaaagagctcctgaccgagaaccaccagctgaaagaagccatgaagcta
aataatcaagccatgaaagggagatttgaggagctttcggcctggacagagaaacagaag
gaagaacgccagttttttgagatacagagcaaagaagcaaaagagcgtctaatggccttg
agtcatgagaatgagaaattgaaggaagagcttggaaaactaaaagggaaatcagaaagg
tcatctgaggaccccactgatgactccaggcttcccagggccgaagcggagcaggaaaag
gaccagctcaggacccaggtggtgaggctacaagcagagaaggcagacctgttgggcatc
gtgtctgaactgcagctcaagctgaactccagcggctcctcagaagattcctttgttgaa
attaggatggctgaaggagaagcagaagggtcagtaaaagaaatcaagcatagtcctggg
cccacgagaacagtctccactggcacggcattgtctaaatataggagcagatctgcagat
ggggccaagaattacttcgaacatgaggagttaactgtgagccagctcctgctgtgccta
agggaagggaatcagaaggtggagagacttgaagttgcactcaaggaggccaaagaaaga
gtttcagattttgaaaagaaaacaagtaatcgttctgagattgaaacccagacagagggg
agcacagagaaagagaatgatgaagagaaaggcccggagactgttggaagcgaagtggaa
gcactgaacctccaggtgacatctctgtttaaggagcttcaagaggctcatacaaaactc
agcgaagctgagctaatgaagaagagacttcaagaaaagtgtcaggcccttgaaaggaaa
aattctgcaattccatcagagttgaatgaaaagcaagagcttgtttatactaacaaaaag
ttagagctacaagtggaaagcatgctatcagaaatcaaaatggaacaggctaaaacagag
gatgaaaagtccaaattaactgtgctacagatgacacacaacaagcttcttcaagaacat
aataatgcattgaaaacaattgaggaactaacaagaaaagagtcagaaaaagtggacagg
gcagtgctgaaggaactgagtgaaaaactggaactggcagagaaggctctggcttccaaa
cagctgcaaatggatgaaatgaagcaaaccattgccaagcaggaagaggacctggaaacc
atgaccatcctcagggctcagatggaagtttactgttctgattttcatgctgaaagagca
gcgagagagaaaattcatgaggaaaaggagcaactggcattgcagctggcagttctgctg
aaagagaatgatgctttcgaagacggaggcaggcagtccttgatggagatgcagagtcgt
catggggcgagaacaagtgactctgaccagcaggcttaccttgttcaaagaggagctgag
gacagggactggcggcaacagcggaatattccgattcattcctgccccaagtgtggagag
gttctgcctgacatagacacgttacagattcacgtgatggattgcatcatttaa

KEGG   Homo sapiens (human): 10241
Entry
10241             CDS       T01001                                 
Symbol
CALCOCO2, NDP52
Name
(RefSeq) calcium binding and coiled-coil domain 2
  KO
K21348  calcium-binding and coiled-coil domain-containing protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa05131  Shigellosis
hsa05164  Influenza A
Network
nt06170  Influenza A virus (IAV)
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06519  RLR signaling
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00734  IAV PB1-F2/PB2 to RIG-I-like receptor signaling pathway
N01137  PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    10241 (CALCOCO2)
   04137 Mitophagy - animal
    10241 (CALCOCO2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    10241 (CALCOCO2)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    10241 (CALCOCO2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10241 (CALCOCO2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    10241 (CALCOCO2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Xenophagy
   Cargo receptors
    10241 (CALCOCO2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    10241 (CALCOCO2)
SSDB
Motif
Pfam: SKICH Zn-C2H2_12 NAD_binding_10 CheW Crescentin DUF2126
Other DBs
NCBI-GeneID: 10241
NCBI-ProteinID: NP_005822
OMIM: 604587
HGNC: 29912
Ensembl: ENSG00000136436
UniProt: Q13137
Structure
LinkDB
Position
17:48831035..48865245
AA seq 446 aa
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFR
VGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGAS
IPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKK
QEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQ
EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ
QELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQV
PTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCF
NCPICDKIFPATEKQIFEDHVFCHSL
NT seq 1341 nt   +upstreamnt  +downstreamnt
atggaggagaccatcaaagatccccccacatcagctgtcttgctggatcactgtcatttc
tctcaggtcatctttaacagtgtggagaagttctacatccctggaggggacgtcacatgt
cattataccttcacccagcatttcatccctcgtcgaaaggattggattggcatctttaga
gtggggtggaagacaacccgtgagtattacaccttcatgtgggttactttgcccattgac
ctaaacaacaaatcagctaaacagcaggaagtccaattcaaagcttactacctgcccaag
gatgatgagtattaccagttctgctatgtggatgaggatggtgtggtccggggagcaagt
attcctttccaattccgtccagaaaatgaggaagacatcctggttgttaccactcaggga
gaggtggaagagattgagcagcacaacaaggagctttgcaaagaaaaccaggagctgaag
gacagctgtatcagcctccagaagcagaactcagacatgcaggctgagctccaaaagaag
caggaggagctagaaaccctacagagcatcaataagaagttggaactgaaagtgaaagaa
cagaaggactattgggagacagagctgcttcaactgaaagaacaaaaccagaagatgtcc
tcagaaaatgagaagatgggaatcagagtggatcagcttcaggcccagctgtcaactcaa
gagaaagaaatggagaagcttgttcagggagatcaagataagacagagcagttagagcag
ctgaaaaaggaaaatgaccacctctttctcagtttaactgaacagaggaaggaccagaag
aagctcgagcagacagtggagcaaatgaagcagaatgaaactactgcaatgaagaaacaa
caggaattaatggatgaaaactttgacctgtcaaaaagactgagtgagaacgaaattata
tgtaatgctctgcagagacagaaagagagattggaaggagaaaatgatcttttgaagagg
gagaacagcagattgctcagttacatgggtctggattttaattctttgccgtatcaagta
cctacttcagatgaaggaggcgcaagacaaaatccaggacttgcctatggaaacccatat
tctggtatccaagaaagttcttcccccagcccgctctccatcaagaaatgccctatctgc
aaagcagatgatatttgtgatcacaccttggagcaacagcagatgcagcccctttgtttc
aattgtccaatttgtgacaagatcttcccagctacagagaagcagatctttgaagaccac
gtgttctgccactctctctga

KEGG   Homo sapiens (human): 8887
Entry
8887              CDS       T01001                                 
Symbol
TAX1BP1, CALCOCO3, T6BP, TXBP151
Name
(RefSeq) Tax1 binding protein 1
  KO
K21347  Tax1-binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
Network
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N01137  PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    8887 (TAX1BP1)
   04137 Mitophagy - animal
    8887 (TAX1BP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8887 (TAX1BP1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    8887 (TAX1BP1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    8887 (TAX1BP1)
  Xenophagy
   Cargo receptors
    8887 (TAX1BP1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    8887 (TAX1BP1)
SSDB
Motif
Pfam: SKICH CALCOCO1 Zn-C2H2_12 UBZ_FAAP20
Other DBs
NCBI-GeneID: 8887
NCBI-ProteinID: NP_006015
OMIM: 605326
HGNC: 11575
Ensembl: ENSG00000106052
UniProt: Q86VP1
Structure
LinkDB
Position
7:27739373..27829767
AA seq 789 aa
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTA
RDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQF
RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS
VTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE
VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE
EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD
QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK
TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK
CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER
KMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRP
PVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCF
DSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTH
FDQNVLNFD
NT seq 2370 nt   +upstreamnt  +downstreamnt
atgacatcctttcaagaagtcccattgcagacttccaactttgcccatgtcatctttcaa
aatgtggccaagagttaccttcctaatgcacacctggaatgtcattacaccttaactcca
tatattcatccacatccaaaagattgggttggtatattcaaggttggatggagtactgct
cgtgattattacacgtttttatggtcccctatgcctgaacattatgtggaaggatcaaca
gtcaattgtgtactagcattccaaggatattaccttccaaatgatgatggagaattttat
cagttctgttacgttacccataagggtgaaattcgtggagcaagtacacctttccagttt
cgagcttcttctccagttgaagagctgcttactatggaagatgaaggaaattctgacatg
ttagtggtgaccacaaaagcaggccttcttgagttgaaaattgagaaaaccatgaaagaa
aaagaagaactgttaaagttaattgccgttctggaaaaagaaacagcacaacttcgagaa
caagttgggagaatggaaagagaacttaaccatgagaaagaaagatgtgaccaactgcaa
gcagaacaaaagggtcttactgaagtaacacaaagcttaaaaatggaaaatgaagagttt
aagaagaggttcagtgatgctacatccaaagcccatcagcttgaggaagatattgtgtca
gtaacacataaagcaattgaaaaagaaaccgaattagacagtttaaaggacaaactcaag
aaggcacaacatgaaagagaacaacttgaatgtcagttgaagacagagaaggatgaaaag
gaactttataaggtacatttgaagaatacagaaatagaaaataccaagcttatgtcagag
gtccagactttaaaaaatttagatgggaacaaagaaagcgtgattactcatttcaaagaa
gagattggcaggctgcagttatgtttggctgaaaaggaaaatctgcaaagaactttcctg
cttacaacctcaagtaaagaagatacttgttttttaaaggagcaacttcgtaaagcagag
gaacaggttcaggcaactcggcaagaagttgtctttctggctaaagaactcagtgatgct
gtcaacgtacgagacagaacgatggcagacctgcatactgcacgcttggaaaacgagaaa
gtgaaaaagcagttagctgatgcagtggcagaacttaaactaaatgctatgaaaaaagat
caggacaagactgatacactggaacacgaactaagaagagaagttgaagatctgaaactc
cgtcttcagatggctgcagaccattataaagaaaaatttaaggaatgccaaaggctccaa
aaacaaataaacaaactttcagatcaatcagctaataataataatgtcttcacaaagaaa
acggggaatcagcagaaagtgaatgatgcttcagtaaacacagacccagccacttctgcc
tctactgtagatgtaaagccatcaccttctgcagcagaggcagattttgacatagtaaca
aaggggcaagtctgtgaaatgaccaaagaaattgctgacaaaacagaaaagtataataaa
tgtaaacaactcttgcaggatgagaaagcaaaatgcaataaatatgctgatgaacttgca
aaaatggagctgaaatggaaagaacaagtgaaaattgctgaaaatgtaaaacttgaacta
gctgaagtacaggacaattataaagaacttaaaaggagtctagaaaatccagcagaaagg
aaaatggaaggtcagaattcccagagtcctcaatgtttcaaaacatgctcagagcaaaat
ggttatgttctcacattgtcaaatgcacaaccagttctgcaatatggtaatccttatgca
tctcaggaaacaagagatggagcagatggtgctttttacccagatgaaatacaaaggcca
cctgtcagagtcccctcttggggactggaagacaatgttgtctgcagccagcctgctcga
aactttagtcggcctgatggcttagaggactctgaggatagcaaagaagatgagaatgtg
cctactgctcctgatcctccaagtcaacatttacgtgggcatgggacaggcttttgcttt
gattccagctttgatgttcacaagaagtgtcccctctgtgagttaatgtttcctcctaac
tatgatcagagcaaatttgaagaacatgttgaaagtcactggaaggtgtgcccgatgtgc
agcgagcagttccctcctgactatgaccagcaggtgtttgaaaggcatgtgcagacccat
tttgatcagaatgttctaaattttgactag

KEGG   Homo sapiens (human): 4077
Entry
4077              CDS       T01001                                 
Symbol
NBR1, 1A1-3B, IAI3B, M17S2, MIG19
Name
(RefSeq) NBR1 autophagy cargo receptor
  KO
K17987  next to BRCA1 gene 1 protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
Network
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N01137  PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    4077 (NBR1)
   04137 Mitophagy - animal
    4077 (NBR1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4077 (NBR1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4077 (NBR1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    4077 (NBR1)
  Pexophagy
   Other pexophagy associated proteins
    4077 (NBR1)
  Aggrephagy
   Cargo receptors
    4077 (NBR1)
  Xenophagy
    4077 (NBR1)
  Other autophagy associated proteins
   Midbophagy
    4077 (NBR1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    4077 (NBR1)
SSDB
Motif
Pfam: N_BRCA1_IG PB1 UBA_NBR1_C ZZ CENP-B_dimeris Sgf11
Other DBs
NCBI-GeneID: 4077
NCBI-ProteinID: NP_005890
OMIM: 166945
HGNC: 6746
Ensembl: ENSG00000188554
UniProt: Q14596
Structure
LinkDB
Position
17:43170409..43211688
AA seq 966 aa
MEPQVTLNVTFKNEIQSFLVSDPENTTWADIEAMVKVSFDLNTIQIKYLDEENEEVSINS
QGEYEEALKMAVKQGNQLQMQVHEGHHVVDEAPPPVVGAKRLAARAGKKPLAHYSSLVRV
LGSDMKTPEDPAVQSFPLVPCDTDQPQDKPPDWFTSYLETFREQVVNETVEKLEQKLHEK
LVLQNPSLGSCPSEVSMPTSEETLFLPENQFSWHIACNNCQRRIVGVRYQCSLCPSYNIC
EDCEAGPYGHDTNHVLLKLRRPVVGSSEPFCHSKYSTPRLPAALEQVRLQKQVDKNFLKA
EKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLP
LQPCTSVMPMLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLT
LASTEKKDVLVPCLKAGHVGVVSVEFIAPALEGTYTSHWRLSHKGQQFGPRVWCSIIVDP
FPSEESPDNIEKGMISSSKTDDLTCQQEETFLLAKEERQLGEVTEQTEGTAACIPQKAKN
VASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPCMSPLPHDSPLIE
KPGLGQIEEENEGAGFKALPDSMVSVKRKAENIASVEEAEEDLSGTQFVCETVIRSLTLD
AAPDHNPPCRQKSLQMTFALPEGPLGNEKEEIIHIAEEEAVMEEEEDEEDEEEEDELKDE
VQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGKPGVEAGQEPAEAG
ERLPGGENQPQEHSISDILTTSQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPV
TIPEVSSVPDQIRGEPRGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKAL
FAGPPVTAQPIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTELLQLNNND
WYSQRY
NT seq 2901 nt   +upstreamnt  +downstreamnt
atggaaccacaggttactctaaatgtgacttttaaaaatgaaattcaaagctttctggtt
tctgatccagaaaatacaacttgggctgatatcgaagctatggtaaaagtttcatttgat
ctgaatactattcaaataaaatacctggatgaggaaaatgaagaggtatccatcaacagt
caaggagaatatgaagaagcgcttaagatggcagttaaacagggaaaccaactgcagatg
caagtccacgaagggcaccatgtcgttgatgaagccccacccccagttgtaggagcaaaa
cgactagctgccagggcagggaagaagccacttgcacattactcttcactggtgagagtc
ttgggatcagacatgaagaccccagaggatcctgcagtgcagtcgtttccacttgttcca
tgtgacacagaccagcctcaagacaagcccccagactggttcacaagctacctggagacg
ttcagagaacaagtggttaacgaaacggttgagaagcttgaacagaaattacatgaaaag
cttgtcctccagaacccatccttgggttcttgtccctcagaagtctcaatgcctacttca
gaagaaacattgtttttgccagaaaaccagttcagctggcatattgcttgcaacaactgc
caaagaaggattgttggtgtccgctaccagtgtagcctatgcccatcctacaatatctgt
gaagattgtgaagcagggccatatggccatgacactaaccacgtcctgctgaagttgcgg
agacctgttgtgggctcctctgaaccgttctgtcactcaaagtactctactcctcgtctt
cctgctgctctggaacaagtcaggctccagaaacaggttgataagaactttcttaaagca
gaaaagcaaaggttgcgagctgagaagaaacaacgtaaagcagaggtcaaggaacttaaa
aagcagcttaaactccataggaaaattcacctgtggaattcaatccatggactccagagc
cccaagtctcctttaggccgacctgagagcttgctccagtctaataccctgatgctccct
ttgcagccctgtacctccgttatgccaatgctcagtgcagcatttgtggatgagaatttg
cctgatgggactcaccttcagccaggaaccaagtttatcaaacactggaggatgaaaaat
acaggaaatgtaaagtggagtgcagacacaaagctcaagttcatgtggggaaacctgact
ttggcttccacagaaaagaaggatgttttggttccctgcctcaaggccggccatgtggga
gttgtatctgtggagttcattgccccagccttggagggaacgtatacttcccattggcgt
ctttctcacaaaggccagcaatttgggcctcgggtctggtgcagtatcatagtagatcct
ttcccctccgaagagagccctgataacattgaaaagggcatgatcagctcaagcaaaact
gatgatctcacctgccagcaagaggaaacttttcttctggctaaagaagaaagacagctt
ggtgaagtgactgagcagacagaagggacagcagcctgcatcccacagaaggcaaaaaat
gttgccagtgagagggagctctacatcccatctgtggatcttctgactgcccaggacctg
ctgtcctttgagctgttggatataaacattgttcaagagttggagagagtgccccacaac
acccctgtggatgtgactccctgcatgtctcctctgccacatgacagtcctttaatagag
aagccaggcttggggcagatagaggaagagaatgaaggggcaggatttaaagcacttcct
gattctatggtgtcagtaaagaggaaggctgagaacattgcttctgtggaggaagcagaa
gaagacctgagtgggacccagtttgtgtgtgagacagtaatccgatcccttaccttggat
gctgccccagaccacaaccctccttgcagacagaagtccttgcagatgacatttgccttg
cctgaaggaccacttggaaatgagaaggaggagattatccatatcgctgaggaagaagct
gtcatggaggaggaggaggatgaggaggatgaggaggaggaggatgagctcaaagatgaa
gttcaaagtcagtcctctgcttcctcagaggattacatcatcatcctgcctgagtgcttt
gataccagccgccccctgggggattctatgtacagctctgcgctctcacagccaggcctg
gagcgaggtgctgaaggcaagcctggggttgaggctgggcaggaaccagctgaggctggg
gaaagactccctggaggggagaaccagccacaggagcacagcataagtgacatcctcacg
acctcacagactctggaaacagtgcccctaatcccagaggtagtggagcttccaccgtca
ctgcccaggagctctccttgtgtacatcatcatggttccccaggagtggatttaccagtt
accataccagaagtttcttcagtccctgatcagatcagaggagagcccagaggctcatca
ggacttgtaaacagcagacagaagagctatgaccactcaaggcaccatcatgggagcagc
attgctggaggactggtgaagggggctttgtctgttgctgcctctgcatacaaggccctg
tttgctgggccaccagtcactgcacagccaataatttctgaagatcagacagcagccctg
atggcccatctctttgaaatgggattctgtgacaggcagctgaacctacggctgctgaag
aaacacaattacaatatcctgcaggttgtgacagaacttcttcagttaaacaacaacgac
tggtacagccaacgctattga

KEGG   Homo sapiens (human): 84557
Entry
84557             CDS       T01001                                 
Symbol
MAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3
Name
(RefSeq) microtubule associated protein 1 light chain 3 alpha
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    84557 (MAP1LC3A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    84557 (MAP1LC3A)
   04137 Mitophagy - animal
    84557 (MAP1LC3A)
  09143 Cell growth and death
   04216 Ferroptosis
    84557 (MAP1LC3A)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    84557 (MAP1LC3A)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    84557 (MAP1LC3A)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    84557 (MAP1LC3A)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    84557 (MAP1LC3A)
   05022 Pathways of neurodegeneration - multiple diseases
    84557 (MAP1LC3A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    84557 (MAP1LC3A)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    84557 (MAP1LC3A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    84557 (MAP1LC3A)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    84557 (MAP1LC3A)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    84557 (MAP1LC3A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     84557 (MAP1LC3A)
SSDB
Motif
Pfam: ATG8 APG12 YneP
Other DBs
NCBI-GeneID: 84557
NCBI-ProteinID: NP_115903
OMIM: 601242
HGNC: 6838
Ensembl: ENSG00000101460
UniProt: Q9H492
Structure
LinkDB
Position
20:34546844..34560345
AA seq 121 aa
MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFG
F
NT seq 366 nt   +upstreamnt  +downstreamnt
atgccctcagaccggcctttcaagcagcggcggagcttcgccgaccgctgtaaggaggta
cagcagatccgcgaccagcaccccagcaaaatcccggtgatcatcgagcgctacaagggt
gagaagcagctgcccgtcctggacaagaccaagtttttggtcccggaccatgtcaacatg
agcgagttggtcaagatcatccggcgccgcctgcagctgaaccccacgcaggccttcttc
ctgctggtgaaccagcacagcatggtgagtgtgtccacgcccatcgcggacatctacgag
caggagaaagacgaggacggcttcctctatatggtctacgcctcccaggaaaccttcggc
ttctga

KEGG   Homo sapiens (human): 81631
Entry
81631             CDS       T01001                                 
Symbol
MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
Name
(RefSeq) microtubule associated protein 1 light chain 3 beta
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    81631 (MAP1LC3B)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    81631 (MAP1LC3B)
   04137 Mitophagy - animal
    81631 (MAP1LC3B)
  09143 Cell growth and death
   04216 Ferroptosis
    81631 (MAP1LC3B)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    81631 (MAP1LC3B)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    81631 (MAP1LC3B)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    81631 (MAP1LC3B)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    81631 (MAP1LC3B)
   05022 Pathways of neurodegeneration - multiple diseases
    81631 (MAP1LC3B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    81631 (MAP1LC3B)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    81631 (MAP1LC3B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    81631 (MAP1LC3B)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    81631 (MAP1LC3B)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    81631 (MAP1LC3B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     81631 (MAP1LC3B)
SSDB
Motif
Pfam: ATG8 APG12 Rad60-SLD
Other DBs
NCBI-GeneID: 81631
NCBI-ProteinID: NP_073729
OMIM: 609604
HGNC: 13352
Ensembl: ENSG00000140941
UniProt: Q9GZQ8 Q658J6
Structure
LinkDB
Position
16:87392336..87404774
AA seq 125 aa
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG
MKLSV
NT seq 378 nt   +upstreamnt  +downstreamnt
atgccgtcggagaagaccttcaagcagcgccgcaccttcgaacaaagagtagaagatgtc
cgacttattcgagagcagcatccaaccaaaatcccggtgataatagaacgatacaagggt
gagaagcagcttcctgttctggataaaacaaagttccttgtacctgaccatgtcaacatg
agtgagctcatcaagataattagaaggcgcttacagctcaatgctaatcaggccttcttc
ctgttggtgaacggacacagcatggtcagcgtctccacaccaatctcagaggtgtatgag
agtgagaaagatgaagatggattcctgtacatggtctatgcctcccaggagacgttcggg
atgaaattgtcagtgtaa

KEGG   Homo sapiens (human): 643246
Entry
643246            CDS       T01001                                 
Symbol
MAP1LC3B2, ATG8G
Name
(RefSeq) microtubule associated protein 1 light chain 3 beta 2
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    643246 (MAP1LC3B2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    643246 (MAP1LC3B2)
   04137 Mitophagy - animal
    643246 (MAP1LC3B2)
  09143 Cell growth and death
   04216 Ferroptosis
    643246 (MAP1LC3B2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    643246 (MAP1LC3B2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    643246 (MAP1LC3B2)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    643246 (MAP1LC3B2)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    643246 (MAP1LC3B2)
   05022 Pathways of neurodegeneration - multiple diseases
    643246 (MAP1LC3B2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    643246 (MAP1LC3B2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    643246 (MAP1LC3B2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    643246 (MAP1LC3B2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    643246 (MAP1LC3B2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    643246 (MAP1LC3B2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     643246 (MAP1LC3B2)
SSDB
Motif
Pfam: ATG8 APG12 Rad60-SLD ATG5_UblB
Other DBs
NCBI-GeneID: 643246
NCBI-ProteinID: NP_001078950
OMIM: 620673
HGNC: 34390
Ensembl: ENSG00000258102
UniProt: A6NCE7
LinkDB
Position
12:116559381..116576606
AA seq 125 aa
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVCASQETFG
MKLSV
NT seq 378 nt   +upstreamnt  +downstreamnt
atgccgtcggagaagaccttcaagcagcggcgcaccttcgaacaaagagtagaagatgtc
cgacttattcgagagcagcatccaaccaaaatcccggtgataatagaacgatacaagggt
gagaagcagcttcctgttctggataaaacaaagttccttgtacctgaccatgtcaacatg
agtgagctcatcaagataattagaaggcgcttacagctcaatgctaatcaggccttcttc
ctgttggtgaacggacacagcatggtcagcgtctccacaccaatctcagaggtgtatgag
agtgagaaagatgaagatggattcctgtacatggtctgtgcctcccaggagacgttcggg
atgaaattgtcagtgtaa

KEGG   Homo sapiens (human): 440738
Entry
440738            CDS       T01001                                 
Symbol
MAP1LC3C, ATG8J, LC3C
Name
(RefSeq) microtubule associated protein 1 light chain 3 gamma
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    440738 (MAP1LC3C)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    440738 (MAP1LC3C)
   04137 Mitophagy - animal
    440738 (MAP1LC3C)
  09143 Cell growth and death
   04216 Ferroptosis
    440738 (MAP1LC3C)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    440738 (MAP1LC3C)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    440738 (MAP1LC3C)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    440738 (MAP1LC3C)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    440738 (MAP1LC3C)
   05022 Pathways of neurodegeneration - multiple diseases
    440738 (MAP1LC3C)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    440738 (MAP1LC3C)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    440738 (MAP1LC3C)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    440738 (MAP1LC3C)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    440738 (MAP1LC3C)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    440738 (MAP1LC3C)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     440738 (MAP1LC3C)
SSDB
Motif
Pfam: ATG8 APG12
Other DBs
NCBI-GeneID: 440738
NCBI-ProteinID: NP_001004343
OMIM: 609605
HGNC: 13353
Ensembl: ENSG00000197769
UniProt: Q9BXW4
Structure
LinkDB
Position
1:complement(241995490..242001393)
AA seq 147 aa
MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLV
PQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYA
SQETFGCLESAAPRDGSSLEDRPCNPL
NT seq 444 nt   +upstreamnt  +downstreamnt
atgccgcctccacagaaaatcccaagcgtcagacccttcaagcagaggaaaagcttggca
atcagacaagaggaagttgctggaatccgggcaaagttccccaacaaaatcccggtggta
gtggagcgctaccccagggagacgttcctgcccccgctggacaaaaccaagttcctggtc
ccgcaggagctgaccatgacccagttcctcagcatcatccggagccgcatggtcctgaga
gccacggaagccttttacttgctggtgaacaacaagagcctggtcagcatgagcgcaacc
atggcagagatctacagagactacaaggatgaggatggcttcgtgtacatgacctacgcc
tcccaggagacatttggctgcctggagtcagcagcccccagggatgggagcagccttgag
gacagaccctgcaatcctctctag

KEGG   COMPOUND: C00350
Entry
C00350                      Compound                               
Name
Phosphatidylethanolamine;
(3-Phosphatidyl)ethanolamine;
(3-Phosphatidyl)-ethanolamine;
Cephalin;
O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine;
1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine;
L-1-Phosphatidylethanolamine
Formula
C7H12NO8PR2
Structure
Remark
ATC code: A05BA10
Comment
Generic compound in reaction hierarchy
Reaction
R02051 R02052 R02053 R02054 R02055 R02056 R02057 R04480
R04864 R05923 R05924 R07376 R08107 R11062 R11204 R11205
R11555 R11556 R11557 R12202 R12351 R12702 R13541
Pathway
map00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
map00564  Glycerophospholipid metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04136  Autophagy - other
map04138  Autophagy - yeast
map04140  Autophagy - animal
map04723  Retrograde endocannabinoid signaling
map05130  Pathogenic Escherichia coli infection
map05167  Kaposi sarcoma-associated herpesvirus infection
Module
M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC
M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
M00093  Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
Enzyme
2.1.1.17        2.3.1.23        2.3.1.40        2.7.8.1         
2.7.8.29        2.7.8.42        2.7.8.43        2.7.8.48        
2.7.8.-         2.7.-.-         3.1.1.4         3.1.1.32        
3.1.4.3         3.1.4.4         3.1.4.62        4.1.1.65
Brite
Compounds with biological roles [BR:br08001]
 Lipids
  Phospholipids
   Glycerophospholipids
    C00350  Phosphatidylethanolamine
Lipids [BR:br08002]
 GP  Glycerophospholipids
  GP02 Glycerophosphoethanolamines
   GP0201 Diacylglycerophosphoethanolamines
    C00350  1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A05 BILE AND LIVER THERAPY
   A05B LIVER THERAPY, LIPOTROPICS
    A05BA Liver therapy
     A05BA10 Phospholipids
      C00350  Phosphatidylethanolamine
Other DBs
CAS: 39382-08-6
PubChem: 3643
ChEBI: 16038
LinkDB
KCF data

ATOM        19
            1   C1c C    24.0320  -15.8183
            2   C1b C    24.0437  -17.6595
            3   C1b C    24.0437  -14.0877
            4   O7a O    22.4646  -15.8473
            5   O2b O    25.3780  -17.6595
            6   O7a O    25.3780  -14.0877
            7   C7a C    21.1302  -15.8473
            8   P1b P    26.7064  -17.6595
            9   C7a C    26.7064  -14.0877
            10  O6a O    21.1245  -14.5072
            11  R   R    19.8017  -15.8473
            12  O2b O    28.0408  -17.6595
            13  O1c O    26.7707  -18.9996
            14  O1c O    26.7064  -16.2727
            15  O6a O    26.7707  -12.7534
            16  R   R    28.0408  -14.0877
            17  C1b C    29.1946  -16.9952
            18  C1b C    30.3541  -17.6595
            19  N1a N    31.5077  -16.9952
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 2
            10    7  11 1
            11    8  12 1
            12    8  13 1
            13    8  14 2
            14    9  15 2
            15    9  16 1
            16   12  17 1
            17   17  18 1
            18   18  19 1

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