KEGG PATHWAY: iti00260

PATHWAY: iti00260

Entry

iti00260                    Pathway

Name

Glycine, serine and threonine metabolism - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

iti00260

Glycine, serine and threonine metabolism

Module

iti_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:iti00260]

iti_M00047

Creatine pathway [PATH:iti00260]

iti_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:iti00260]

iti_M00555

Betaine biosynthesis, choline => betaine [PATH:iti00260]

iti_M00621

Glycine cleavage system [PATH:iti00260]

iti_M00974

Betaine metabolism, animals, betaine => glycine [PATH:iti00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]

Gene

101956462

Gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

101957104

Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

101957967

Dao; D-amino-acid oxidase isoform X2 [KO:K00273] [EC:1.4.3.3]

101958433

Chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

101959737

[KO:K02437]

101961149

Alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

101961176

Phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

101961581

[KO:K15789] [EC:1.1.1.103]

101962003

Srr; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]

101962482

Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]

101962992

Sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

101963274

Sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

101963703

Grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

101963999

Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

101964621

Gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

101965063

Aldh7a1; LOW QUALITY PROTEIN: alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

101966593

[KO:K02437]

101967088

Cbs; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]

101967980

Sardh; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]

101968274

Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

101968393

Shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

101968540

Pipox; peroxisomal sarcosine oxidase isoform X6 [KO:K00306] [EC:1.5.3.1 1.5.3.7]

101968763

Shmt2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]

101968947

Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

101970149

Gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

101970948

Cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

101971615

Dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

101971961

Gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]

101972215

[KO:K00544] [EC:2.1.1.5]

101973421

[KO:K00276] [EC:1.4.3.21]

101973452

Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

101973899

[KO:K00276] [EC:1.4.3.21]

101973993

Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

101974275

Maob; amine oxidase [flavin-containing] B isoform X2 [KO:K00274] [EC:1.4.3.4]

101974314

Psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

101975053

[KO:K01620] [EC:4.1.2.48]

101975557

Dld; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]

101976874

Agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

101977513

Alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

101977853

Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

101977937

[KO:K01620] [EC:4.1.2.48]

101978024

Psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

101978482

[KO:K00276] [EC:1.4.3.21]

110598324

Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721