KEGG   PATHWAY: iti00230
Entry
iti00230                    Pathway                                
Name
Purine metabolism - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Class
Metabolism; Nucleotide metabolism
Pathway map
iti00230  Purine metabolism
iti00230

Module
iti_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:iti00230]
iti_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:iti00230]
iti_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:iti00230]
iti_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:iti00230]
iti_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:iti00230]
iti_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:iti00230]
iti_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:iti00230]
Other DBs
GO: 0006163 0042278
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954340  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
101954652  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
101954661  Prune1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
101954767  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101955034  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
101955123  [KO:K00364] [EC:1.7.1.7]
101955295  Npr2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
101955334  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
101955464  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
101955741  [KO:K11265] [EC:4.6.1.1]
101955912  Prps2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
101956173  Ampd3; AMP deaminase 3 isoform X4 [KO:K01490] [EC:3.5.4.6]
101956387  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
101956538  Nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
101956546  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101956777  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3 [KO:K13293] [EC:3.1.4.53]
101956813  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X2 [KO:K13756] [EC:3.1.4.35]
101957289  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
101957434  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
101957960  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101958018  [KO:K00939] [EC:2.7.4.3]
101958364  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [KO:K18437] [EC:3.1.4.53]
101958436  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
101958555  Guk1; guanylate kinase isoform X3 [KO:K00942] [EC:2.7.4.8]
101958661  [KO:K07127] [EC:3.5.2.17]
101959120  Ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
101959732  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
101960076  Adsl; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
101960143  Urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
101960362  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
101960436  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101960453  Ak1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
101960579  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
101960605  [KO:K07127] [EC:3.5.2.17]
101960649  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101960675  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101960767  Gart; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
101960776  [KO:K00948] [EC:2.7.6.1]
101960836  Ada2; LOW QUALITY PROTEIN: adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
101961111  Ppat; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
101961407  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
101961646  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
101961852  Adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
101962151  Gmpr2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
101962415  Gucy2c; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
101962750  [KO:K11265] [EC:4.6.1.1]
101962963  Dguok; deoxyguanosine kinase, mitochondrial isoform X2 [KO:K00904] [EC:2.7.1.113]
101963035  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
101963099  Nt5dc4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
101963339  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
101963750  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X2 [KO:K13293] [EC:3.1.4.53]
101964175  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101964456  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101964555  Adk; adenosine kinase isoform X2 [KO:K00856] [EC:2.7.1.20]
101964576  [KO:K12319] [EC:4.6.1.2]
101964663  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
101964767  Atic; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
101964920  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101965092  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
101965564  Pfas; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
101965601  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X8 [KO:K13755] [EC:3.1.4.17]
101965734  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101965866  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
101965901  Pgm2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
101965905  Itpa; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
101965923  Gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
101966007  [KO:K00939] [EC:2.7.4.3]
101966018  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X2 [KO:K08718] [EC:3.1.4.35]
101966034  Allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
101966082  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101966267  Pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
101966389  Nudt5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
101966455  [KO:K00365] [EC:1.7.3.3]
101966585  Ak8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
101966627  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
101966757  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
101966810  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101967021  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
101967384  Gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
101967661  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
101967734  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101967772  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
101967886  Ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
101967903  Ak4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
101968383  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
101968425  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101968574  Nt5c1a; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
101968613  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X4 [KO:K13761] [EC:3.1.4.35]
101968718  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
101968846  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101968893  Nt5c1b; cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
101969704  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
101969705  Nt5c2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
101969867  [KO:K12321] [EC:4.6.1.2]
101970144  [KO:K03783] [EC:2.4.2.1]
101970881  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X2 [KO:K00088] [EC:1.1.1.205]
101971020  Nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
101971026  Adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
101971038  Gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
101971041  Ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
101971231  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
101971742  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X3 [KO:K01510] [EC:3.6.1.5]
101972188  [KO:K00940] [EC:2.7.4.6]
101972479  [KO:K01488] [EC:3.5.4.4]
101972645  Nme2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
101972720  [KO:K01756] [EC:4.3.2.2]
101972772  Ada; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
101972878  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
101973168  Gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
101973245  Pde3b; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
101973762  Nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
101973773  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
101974441  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
101974505  [KO:K01510] [EC:3.6.1.5]
101974517  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101974533  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101974578  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101974791  [KO:K01510] [EC:3.6.1.5]
101974854  Ak5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
101975116  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5 [KO:K13755] [EC:3.1.4.17]
101975376  [KO:K01081] [EC:3.1.3.5]
101975432  Ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
101975517  Npr1; atrial natriuretic peptide receptor 1 isoform X2 [KO:K12323] [EC:4.6.1.2]
101975706  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
101975943  Nme7; nucleoside diphosphate kinase 7 isoform X3 [KO:K00940] [EC:2.7.4.6]
101976631  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
101976710  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
101976746  Cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
101976750  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
101977147  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
101977190  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
101977704  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
101977788  Adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101977889  Adcy10; adenylate cyclase type 10 isoform X2 [KO:K11265] [EC:4.6.1.1]
101978003  Gucy2f; LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
101978043  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
101978096  Nme4; nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
101978190  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
101978535  [KO:K01081] [EC:3.1.3.5]
102314766  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
120885715  [KO:K13988] [EC:3.6.1.13]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
iti00030  Pentose phosphate pathway
iti00220  Arginine biosynthesis
iti00250  Alanine, aspartate and glutamate metabolism
iti00260  Glycine, serine and threonine metabolism
iti00340  Histidine metabolism
iti00630  Glyoxylate and dicarboxylate metabolism
iti00730  Thiamine metabolism
iti00740  Riboflavin metabolism
iti00790  Folate biosynthesis
KO pathway
ko00230   

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