KEGG   PATHWAY: iti00590
Entry
iti00590                    Pathway                                
Name
Arachidonic acid metabolism - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Class
Metabolism; Lipid metabolism
Pathway map
iti00590  Arachidonic acid metabolism
iti00590

Other DBs
GO: 0019369
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954347  Ptgis; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
101954631  Cbr3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
101954639  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101954908  Cbr1; carbonyl reductase [NADPH] 1 isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101955131  Pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101955436  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101955536  [KO:K07425] [EC:1.14.14.80]
101955561  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101956036  Ltc4s; leukotriene C4 synthase isoform X1 [KO:K00807] [EC:4.4.1.20]
101956089  Ptgr1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
101956312  Pla2g4d; cytosolic phospholipase A2 delta isoform X2 [KO:K16342] [EC:3.1.1.4]
101956431  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101956945  Lta4h; leukotriene A-4 hydrolase isoform X1 [KO:K01254] [EC:3.3.2.6]
101957380  Ptgds; prostaglandin-H2 D-isomerase isoform X1 [KO:K01830] [EC:5.3.99.2]
101957844  [KO:K07412] [EC:1.14.14.1]
101958133  [KO:K07412] [EC:1.14.14.1]
101958450  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101958990  [KO:K07412] [EC:1.14.14.1]
101959170  Zadh2; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
101959207  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101960823  Prxl2b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
101960864  [KO:K01047] [EC:3.1.1.4]
101961078  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101961447  Alox5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101961569  Ggt1; glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101961799  Plb1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101961928  Alox15b; polyunsaturated fatty acid lipoxygenase ALOX15B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101962127  Ggt5; glutathione hydrolase 5 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101962600  Alox12b; arachidonate 12-lipoxygenase, 12R-type isoform X1 [KO:K08021] [EC:1.13.11.-]
101962878  Aloxe3; hydroperoxide isomerase ALOXE3 isoform X1 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
101963157  [KO:K00458] [EC:1.13.11.31]
101963391  Ptges2; prostaglandin E synthase 2 isoform X1 [KO:K05309] [EC:5.3.99.3]
101963440  [KO:K00458] [EC:1.13.11.31]
101964044  Ptges3; prostaglandin E synthase 3 isoform X2 [KO:K15730] [EC:5.3.99.3]
101964311  [KO:K07413] [EC:1.14.14.1]
101966120  [KO:K01831] [EC:5.3.99.4]
101967414  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
101968060  [KO:K00081] [EC:1.1.1.184]
101968308  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
101968980  [KO:K11987] [EC:1.14.99.1]
101969497  Tbxas1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
101971054  [KO:K07413] [EC:1.14.14.1]
101972153  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101972308  Pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101972421  Pla2g4f; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
101972885  [KO:K07413] [EC:1.14.14.1]
101973029  [KO:K07415] [EC:1.14.14.-]
101973126  [KO:K07422] [EC:1.14.14.80]
101973527  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101973674  Alox15; polyunsaturated fatty acid lipoxygenase ALOX15 isoform X1 [KO:K00460] [EC:1.13.11.33]
101973693  Pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101973859  Pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
101973952  Ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101974858  Gpx4; phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K05361] [EC:1.11.1.12]
101975190  Ptgr2; prostaglandin reductase 2 isoform X1 [KO:K13949] [EC:1.3.1.48]
101975502  Hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
101975825  [KO:K01047] [EC:3.1.1.4]
101976106  [KO:K01047] [EC:3.1.1.4]
101976133  Ptgs1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
101976375  [KO:K07413] [EC:1.14.14.1]
101976849  [KO:K07413] [EC:1.14.14.1]
101977048  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101977331  Pla2g5; phospholipase A2 group V isoform X3 [KO:K01047] [EC:3.1.1.4]
101977410  [KO:K07425] [EC:1.14.14.80]
101977429  Ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
101977482  [KO:K07413] [EC:1.14.14.1]
101977604  Pla2g2d; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101977879  [KO:K07425] [EC:1.14.14.80]
101978105  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101978322  [KO:K07413] [EC:1.14.14.1]
110597362  [KO:K15730] [EC:5.3.99.3]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
iti00591  Linoleic acid metabolism
KO pathway
ko00590   

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