KEGG   PATHWAY: mamb04310
Entry
mamb04310                   Pathway                                
Name
Wnt signaling pathway - Megalobrama amblycephala (Wuchang bream)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
mamb04310  Wnt signaling pathway
mamb04310

Other DBs
GO: 0016055
Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125279358  porcn; protein-serine O-palmitoleoyltransferase porcupine isoform X1 [KO:K00181] [EC:2.3.1.250]
125279607  porcnl; porcupine O-acyltransferase like [KO:K00181] [EC:2.3.1.250]
125260827  wnt1; protein Wnt-1 [KO:K03209]
125280138  wnt2bb; wingless-type MMTV integration site family, member 2Bb isoform X1 [KO:K00182]
125273522  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
125254485  wnt2; protein Wnt-2 [KO:K00182]
125255725  wnt3; proto-oncogene Wnt-3 [KO:K00312]
125261241  wnt3a; protein Wnt-3a [KO:K00312]
125243436  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
125256913  wnt4; protein Wnt-4a [KO:K00408]
125244578  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
125280531  wnt5a; protein Wnt-5a [KO:K00444]
125270047  wnt6b; protein Wnt-6 [KO:K00445]
125274299  wnt6a; protein Wnt-6 isoform X1 [KO:K00445]
125244704  wnt7ba; protein Wnt-7b isoform X1 [KO:K00572]
125245007  protein Wnt-7a [KO:K00572]
125247449  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
125256438  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
125259290  wnt8a; protein Wnt-8a ORF1 [KO:K00714]
125259491  protein Wnt-8a ORF2 [KO:K00714]
125277011  wnt8b; protein Wnt-8b [KO:K00714]
125264265  wnt9a; protein Wnt-9a [KO:K01064]
125272011  wnt9b; protein Wnt-9b isoform X1 [KO:K01064]
125270048  wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
125260826  wnt10b; protein Wnt-10b [KO:K01357]
125262197  wnt11; protein Wnt-11 [KO:K01384]
125266061  wnt11f2; protein Wnt-11 [KO:K01384]
125245774  wnt16; protein Wnt-16 [KO:K01558]
125271883  dand5; DAN domain family member 5 [KO:K01645]
125243040  notum1a; palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
125274369  notum2; carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
125257088  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
125245681  wif1; wnt inhibitory factor 1 isoform X1 [KO:K01691]
125255766  sost; sclerostin [KO:K16834]
125271935  dkk2; dickkopf-related protein 2 [KO:K02165]
125255556  dkk1b; dickkopf-related protein 1b isoform X1 [KO:K02165]
125277234  dkk1a; dickkopf WNT signaling pathway inhibitor 1a [KO:K02165]
125243021  serpinf1; pigment epithelium-derived factor [KO:K19614]
125259212  sfrp1b; secreted frizzled-related protein 1b [KO:K02166]
125266511  sfrp1a; secreted frizzled-related protein 1a isoform X1 [KO:K02166]
125272417  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
125249365  sfrp2l; secreted frizzled-related protein 2-like isoform X1 [KO:K02176]
125270667  frzb; secreted frizzled-related protein 3 [KO:K25481]
125277215  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
125243741  rspo1; R-spondin-1 isoform X1 [KO:K19471]
125242953  rspo2; R-spondin-2 [KO:K23097]
125244025  rspo3; R-spondin-3 [KO:K23098]
125264752  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
125259820  LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
125266292  E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
125267378  znrf3; E3 ubiquitin-protein ligase znrf3 isoform X1 [KO:K16273] [EC:2.3.2.27]
125270086  fzd7a; frizzled-7a [KO:K02432]
125244027  fzd1; frizzled-1 [KO:K02432]
125274408  fzd7b; frizzled-7b [KO:K02432]
125276809  fzd2; frizzled-2 [KO:K02235]
125278239  fzd3a; frizzled-3a isoform X1 [KO:K02329]
125268655  fzd3b; frizzled-3b isoform X1 [KO:K02329]
125248200  fzd4; frizzled-4 [KO:K02354]
125258150  fzd8a; LOW QUALITY PROTEIN: frizzled-8a [KO:K02375]
125270265  fzd5; frizzled-5 [KO:K02375]
125250011  fzd8b; frizzled-8b [KO:K02375]
125243351  frizzled-6-like [KO:K02376]
125278659  frizzled-6-like [KO:K02376]
125280132  fzd10; frizzled-10 [KO:K02842]
125254565  fzd9b; frizzled-9b [KO:K02842]
125267905  fzd9a; frizzled-9 [KO:K02842]
125245406  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
125248040  lrp5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
125255730  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
125251496  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [KO:K10162]
125258546  LOW QUALITY PROTEIN: protein APCDD1-like [KO:K25812]
125273556  apcdd1l; protein APCDD1-like [KO:K25812]
125251241  protein APCDD1-like [KO:K25812]
125255056  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
125269380  ccdc88c; protein Daple [KO:K25811]
125259642  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
125265527  dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
125254118  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
125250656  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
125256971  dvl1b; segment polarity protein dishevelled homolog DVL-1b isoform X1 [KO:K02353]
125243756  glycogen synthase kinase binding protein [KO:K03096]
125243540  csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
125265817  csnk2a2a; casein kinase 2, alpha prime polypeptide a [KO:K03097] [EC:2.7.11.1]
125247387  csnk2a2b; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
125276146  zgc:86598; STKc_CK2_alpha domain-containing protein isoform X1 [KO:K03097] [EC:2.7.11.1]
125256598  csnk2a4; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
125274738  csnk2b; casein kinase II subunit beta [KO:K03115]
125243788  nkd2b; protein naked cuticle homolog 2-like [KO:K03213]
125265061  nkd1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
125275089  naked cuticle-like protein 3 isoform X1 [KO:K03213]
125272404  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
125260569  CXXC-type zinc finger protein 4 [KO:K03344]
125274358  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
125249118  uncharacterized protein LOC125249118 isoform X1 [KO:K03345] [EC:3.4.22.68]
125269959  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125271949  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
125243273  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
125275369  catenin beta-1-like [KO:K02105]
125269928  axin1; axin-1 isoform X1 [KO:K02157]
125268478  axin2; axin-2 [KO:K04385]
125262456  apc; LOW QUALITY PROTEIN: adenomatous polyposis coli protein [KO:K02085]
125256485  apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
125258684  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
125253085  tcf7; transcription factor 7 isoform X1 [KO:K02620]
125262345  tcf7l1a; transcription factor 7-like 1-A isoform X1 [KO:K04490]
125280430  tcf7l1b; transcription factor 7-like 1-B [KO:K04490]
125255599  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
125271927  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
125255213  lzts2b; leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
125276607  lzts2a; leucine zipper putative tumor suppressor 2a [KO:K26471]
125260040  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
125255014  cby1; protein chibby homolog 1 [KO:K23402]
125250073  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
125266217  mcc; colorectal mutant cancer protein isoform X1 [KO:K26734]
125262483  ccar2; LOW QUALITY PROTEIN: cell cycle and apoptosis regulator protein 2 [KO:K25816]
125276486  sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
125265876  sox17; transcription factor SOX-17 [KO:K04495]
125258649  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
125258923  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
125255263  ctbp2l; LOW QUALITY PROTEIN: C-terminal binding protein 2, like [KO:K04496] [EC:1.1.1.428]
125268651  ctbp2a; C-terminal-binding protein 2a isoform X1 [KO:K04496] [EC:1.1.1.428]
125263819  tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497]
125263820  tle2b; transducin-like enhancer protein 4 isoform X1 [KO:K04497]
125264779  tle3b; transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
125253848  tle3a; transducin-like enhancer protein 3-A isoform X1 [KO:K04497]
125258225  ctnnd2a; LOW QUALITY PROTEIN: catenin delta-2 [KO:K23491]
125251139  ctnnd2b; catenin delta-2b isoform X1 [KO:K23491]
125262381  crebbpb; LOW QUALITY PROTEIN: CREB binding protein b [KO:K04498] [EC:2.3.1.48]
125263710  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125273590  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125255280  ep300a; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
125256000  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
125273790  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
125262552  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
125243586  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
125266930  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
125275164  smad10a; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
125264790  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
125254113  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
125278037  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
125278531  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
125249494  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
125258151  myca; transcriptional regulator Myc-A [KO:K04377]
125251860  mycb; transcriptional regulator Myc-B [KO:K04377]
125279071  jun; transcription factor AP-1 [KO:K04448]
125266201  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
125259068  fosl1a; fos-related antigen 1a isoform X1 [KO:K04502]
125265759  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
125244649  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
125246743  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
125276432  ccndx; cyclin Dx [KO:K10151]
125263038  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
125243825  ccn4b; cellular communication network factor 4b isoform X1 [KO:K22471]
125274909  ccn4a; cellular communication network factor 4a isoform X1 [KO:K22471]
125263067  pparda; peroxisome proliferator-activated receptor delta [KO:K04504]
125279641  ppardb; peroxisome proliferator-activated receptor delta b isoform X1 [KO:K04504]
125268267  psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
125278182  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125255428  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
125256470  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
125251891  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
125265599  cellular tumor antigen p53-like [KO:K04451]
125266618  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
125254701  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
125251489  calcyclin-binding protein [KO:K04507]
125253090  skp1; S-phase kinase-associated protein 1 [KO:K03094]
125270847  tbl1x; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
125250472  tbl1xr1b; F-box-like/WD repeat-containing protein TBL1XR1b [KO:K04508]
125256301  tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508]
125259455  fbxw11b; F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
125275627  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
125258299  cul1b; cullin-1b [KO:K03347]
125250170  cul1a; cullin-1a isoform X1 [KO:K03347]
125273687  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
125258862  gpc4; glypican-4 [KO:K08110]
125273975  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
125255716  ror2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
125273898  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
125270397  vangl1; vang-like protein 1 isoform X1 [KO:K04510]
125272290  vang-like protein 1 isoform X1 [KO:K04510]
125265266  vangl2; LOW QUALITY PROTEIN: vang-like protein 2 [KO:K04510]
125246457  prickle1b; prickle-like protein 1b isoform X1 [KO:K04511]
125280333  prickle3; prickle planar cell polarity protein 3 isoform X1 [KO:K04511]
125280580  prickle2a; prickle-like protein 2 isoform X1 [KO:K04511]
125246965  prickle1a; prickle-like protein 1a isoform X1 [KO:K04511]
125256166  prickle2b; LOW QUALITY PROTEIN: prickle-like protein 2b [KO:K04511]
125242964  invs; inversin isoform X1 [KO:K19626]
125277987  daam1b; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1b [KO:K04512]
125268454  daam1a; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1 [KO:K04512]
125269154  daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
125263141  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
125279763  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
125279867  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
125280712  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
125273530  rhoca; ras homolog family member Ca [KO:K04513]
125260998  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
125278172  rock2b; rho-associated protein kinase 2b isoform X1 [KO:K17388] [EC:2.7.11.1]
125277100  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
125259154  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125271174  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125271298  rac1l; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125252961  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125254945  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125268403  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
125260328  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
125276092  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
125271584  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
125255025  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
125252240  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125252441  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125255077  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125277047  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125278656  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125278657  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125265626  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125269274  plcb2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
125269307  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125269308  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125252343  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125262414  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
125272496  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
125265885  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
125266459  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
125255303  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
125276818  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
125259177  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
125259186  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125252654  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125265608  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125266516  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
125271895  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
125277514  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
125274046  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
125268438  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125271228  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125272719  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
125242974  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125275441  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
125259721  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
125273340  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
125264815  nfatc3a; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
125247411  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
125251250  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
mamb04010  MAPK signaling pathway
mamb04110  Cell cycle
mamb04115  p53 signaling pathway
mamb04120  Ubiquitin mediated proteolysis
mamb04350  TGF-beta signaling pathway
mamb04510  Focal adhesion
mamb04520  Adherens junction
KO pathway
ko04310   
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