KEGG   PATHWAY: mamb04115
Entry
mamb04115                   Pathway                                
Name
p53 signaling pathway - Megalobrama amblycephala (Wuchang bream)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
mamb04115  p53 signaling pathway
mamb04115

Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125248362  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
125267298  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
125250462  atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
125253492  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
125278214  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
125244871  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
125257003  mdm4; protein Mdm4 isoform X1 [KO:K10127]
125265599  cellular tumor antigen p53-like [KO:K04451]
125266618  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
125253792  ppp1r13l; relA-associated inhibitor isoform X1 [KO:K27356]
125263043  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
125244770  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
125265759  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
125244649  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
125246743  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
125276432  ccndx; cyclin Dx [KO:K10151]
125263038  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
125256866  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
125272351  cdk21; cyclin-dependent kinase 4 [KO:K02091] [EC:2.7.11.22]
125274970  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125244042  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
125265166  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
125256455  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125274308  rprmb; protein reprimo B [KO:K10128]
125260177  rprm3; reprimo, TP53 dependent G2 arrest mediator homolog 3 [KO:K10128]
125269884  rprma; protein reprimo A [KO:K10128]
125254637  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
125267878  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
125264722  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
125268849  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
125279667  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
125253299  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
125273851  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
125251021  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
125256835  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
125251371  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
125253301  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125246957  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
125260831  znf385a; LOW QUALITY PROTEIN: zinc finger protein 385A [KO:K26543]
125268751  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
125246843  pidd1; LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1 [KO:K10130]
125266505  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
125266561  casp22; caspase-22 [KO:K04398] [EC:3.4.22.61]
125274320  casp8l1; caspase 8, apoptosis-related cysteine peptidase, like 1 isoform X1 [KO:K04398] [EC:3.4.22.61]
125274321  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
125268421  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
125269841  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
125254700  bida; BH3 interacting domain death agonist [KO:K04726]
125272083  baxa; BCL2 associated X, apoptosis regulator a [KO:K02159]
125265753  zgc:153993; apoptosis regulator BAX isoform X1 [KO:K02159]
125277032  baxb; BCL2 associated X, apoptosis regulator b isoform X1 [KO:K02159]
125257284  pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
125269258  siva1; apoptosis regulatory protein Siva [KO:K22744]
125260779  bcl2l1; bcl-2-like protein 1 [KO:K04570]
125258583  bcl2a; apoptosis regulator Bcl-2a isoform X1 [KO:K02161]
125251012  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
125268340  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
125262281  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
125263628  shisa10.1; protein shisa-5 [KO:K10135]
125263629  protein shisa-5-like [KO:K10135]
125263630  protein shisa-5-like [KO:K10135]
125277484  p53 apoptosis effector related to PMP-22 [KO:K10136]
125256149  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
125254701  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
125274371  cytochrome c [KO:K08738]
125275401  cytochrome c iso-1/iso-2-like [KO:K08738]
125244334  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
125259921  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
125272552  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
125266884  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
125276675  aifm2; apoptosis-inducing factor 2 [KO:K22745]
125279130  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
125245042  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125264604  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
125276050  adhesion G protein-coupled receptor B1-like [KO:K04596]
125242941  adgrb1a; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
125264627  cd82a; CD82 molecule a [KO:K06509]
125254157  cd82b; CD82 molecule b isoform X1 [KO:K06509]
125277812  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
125269215  thbs1a; thrombospondin-1 [KO:K16857]
125253987  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
125277824  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
125274873  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
125278146  sesn1; sestrin-1 isoform X1 [KO:K10141]
125258994  sesn4; sestrin-3 [KO:K10141]
125248767  sesn3; sestrin-3 [KO:K10141]
125275063  sesn2; sestrin-2 isoform X1 [KO:K20394]
125255050  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125268753  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125271746  tsc2; tuberin isoform X1 [KO:K07207]
125269736  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
125250510  cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
125267272  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
125259346  ccng1; cyclin-G1 [KO:K10145]
125253183  ccng2; cyclin-G2 [KO:K10146]
125249155  ppm1da; protein phosphatase, Mg2+/Mn2+ dependent, 1Da [KO:K10147] [EC:3.1.3.16]
125267914  ppm1db; protein phosphatase, Mg2+/Mn2+ dependent, 1Db [KO:K10147] [EC:3.1.3.16]
125280277  tp73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
mamb04110  Cell cycle
mamb04210  Apoptosis
mamb04218  Cellular senescence
KO pathway
ko04115   
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