KEGG   PATHWAY: maua04720
Entry
maua04720                   Pathway                                
Name
Long-term potentiation - Mesocricetus auratus (golden hamster)
Description
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
Class
Organismal Systems; Nervous system
Pathway map
maua04720  Long-term potentiation
maua04720

Other DBs
GO: 0048169
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101822607  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101822703  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101822879  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101823161  Calm3; calmodulin-3 [KO:K02183]
101823512  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101823756  Rap1b; ras-related protein Rap-1b [KO:K07836]
101824116  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101824692  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101824743  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101825320  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101825355  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101825943  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101825969  [KO:K02183]
101826172  Grin2c; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101826679  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101827090  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101827170  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101827540  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101828136  Prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101828199  Gria2; glutamate receptor 2 isoform X6 [KO:K05198]
101828520  Rapgef3; rap guanine nucleotide exchange factor 3 isoform X4 [KO:K08014]
101828841  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X3 [KO:K04373] [EC:2.7.11.1]
101828975  Calm1; calmodulin-1 [KO:K02183]
101829274  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
101830635  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5 [KO:K04515] [EC:2.7.11.17]
101830949  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101831018  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101831139  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101832112  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101832379  Calm2; calmodulin-2 [KO:K02183]
101833150  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101833206  [KO:K02183]
101833285  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101833722  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13 [KO:K04515] [EC:2.7.11.17]
101834246  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101834401  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101834428  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X23 [KO:K04850]
101834468  Calml4; calmodulin-like protein 4 [KO:K02183]
101834708  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101835944  Kras; GTPase KRas isoform X1 [KO:K07827]
101835945  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101836776  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101836867  Gria1; glutamate receptor 1 isoform X1 [KO:K05197]
101837095  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
101837515  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101838297  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101838431  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101838704  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101838968  Hras; GTPase HRas isoform X1 [KO:K02833]
101840179  [KO:K02183]
101840210  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101840457  [KO:K02183]
101840496  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101840885  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101841141  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
101841273  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101841299  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101841364  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101841668  Mapk3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101841999  Nras; GTPase NRas isoform X1 [KO:K07828]
101842030  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101842762  Ppp1r1a; protein phosphatase 1 regulatory subunit 1A [KO:K08050]
101842987  [KO:K04498] [EC:2.3.1.48]
101843083  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101843997  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
106021831  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
121134668  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
121135759  Calml6; calmodulin-like protein 6 [KO:K02183]
121136988  [KO:K02183]
121137054  [KO:K07828]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00305  Magnesium cation
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
Reference
PMID:15652868
  Authors
Blitzer RD, Iyengar R, Landau EM.
  Title
Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.
  Journal
Biol Psychiatry 57:113-9 (2005)
DOI:10.1016/j.biopsych.2004.02.031
Reference
PMID:10652548
  Authors
Soderling TR, Derkach VA.
  Title
Postsynaptic protein phosphorylation and LTP.
  Journal
Trends Neurosci 23:75-80 (2000)
DOI:10.1016/S0166-2236(99)01490-3
Reference
PMID:11378299
  Authors
Poser S, Storm DR.
  Title
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.
  Journal
Int J Dev Neurosci 19:387-94 (2001)
DOI:10.1016/S0736-5748(00)00094-0
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
  Authors
Purves D, Augustine GJ (ed).
  Title
Neuroscience
  Journal
Sunderland, Mass.:Sinauer Associates (2004)
Reference
PMID:14715912
  Authors
Lynch MA.
  Title
Long-term potentiation and memory.
  Journal
Physiol Rev 84:87-136 (2004)
DOI:10.1152/physrev.00014.2003
Reference
PMID:15857686
  Authors
Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.
  Title
Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
  Journal
Brain Res Mol Brain Res 135:232-48 (2005)
DOI:10.1016/j.molbrainres.2004.12.018
Reference
PMID:9697848
  Authors
Berridge MJ.
  Title
Neuronal calcium signaling.
  Journal
Neuron 21:13-26 (1998)
DOI:10.1016/S0896-6273(00)80510-3
Related
pathway
maua04010  MAPK signaling pathway
maua04020  Calcium signaling pathway
maua04724  Glutamatergic synapse
KO pathway
ko04720   

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