KEGG   PATHWAY: maua04010
Entry
maua04010                   Pathway                                
Name
MAPK signaling pathway - Mesocricetus auratus (golden hamster)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
maua04010  MAPK signaling pathway
maua04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101822366  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
101822393  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101822506  Pdgfra; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101822573  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
101822685  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101822760  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
101822817  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
101822879  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101823016  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101823025  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
101823090  Igf1; insulin-like growth factor I [KO:K05459]
101823176  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101823207  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101823304  Crkl; crk-like protein [KO:K04438]
101823322  Traf2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
101823333  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
101823355  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X3 [KO:K04423] [EC:2.7.11.25]
101823470  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101823512  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101823564  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101823595  Ins; insulin [KO:K04526]
101823598  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101823630  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101823727  Tgfa; protransforming growth factor alpha [KO:K08774]
101823756  Rap1b; ras-related protein Rap-1b [KO:K07836]
101823794  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X3 [KO:K04430] [EC:2.7.12.2]
101823945  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101824029  Igf2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
101824046  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101824111  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101824303  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101824325  [KO:K04393]
101824326  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101824460  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101824626  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101824666  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101824687  Mras; ras-related protein M-Ras [KO:K07831]
101824743  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101824757  Relb; transcription factor RelB isoform X1 [KO:K09253]
101824910  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101825130  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101825262  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101825282  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
101825338  Map3k6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
101825354  Nfkb2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101825464  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101825509  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101825511  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101825585  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101825606  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101825628  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101825756  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
101825767  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101825771  Pspn; persephin [KO:K25416]
101825908  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
101825943  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101826195  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
101826351  Fgfr3; fibroblast growth factor receptor 3 isoform X6 [KO:K05094] [EC:2.7.10.1]
101826372  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101826376  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101826382  Myc; myc proto-oncogene protein [KO:K04377]
101826542  Nf1; neurofibromin isoform X1 [KO:K08052]
101826592  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101826679  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101826731  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101826841  Rras; ras-related protein R-Ras [KO:K07829]
101826972  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X26 [KO:K04407] [EC:2.7.11.1]
101827071  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101827195  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101827594  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X8 [KO:K04859]
101827672  Ptpn7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101827881  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101827925  Angpt4; angiopoietin-4 isoform X2 [KO:K05467]
101828136  Prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101828143  Cacng3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
101828257  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101828272  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101828286  Fgf9; fibroblast growth factor 9 [KO:K04358]
101828307  Nrtn; neurturin [KO:K25414]
101828440  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
101828445  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
101828475  Efna5; ephrin-A5 isoform X1 [KO:K05462]
101828476  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101828578  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101828598  Fgf16; fibroblast growth factor 16 [KO:K04358]
101828609  [KO:K03283]
101828669  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101828703  Fgf7; fibroblast growth factor 7 [KO:K04358]
101828736  Fgfr4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101828841  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X3 [KO:K04373] [EC:2.7.11.1]
101828877  Vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
101828909  Max; protein max isoform X1 [KO:K04453]
101828925  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
101828956  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
101828960  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101829259  Jun; transcription factor AP-1 [KO:K04448]
101829274  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
101829385  Map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
101829556  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101829713  Pdgfc; platelet-derived growth factor C [KO:K05450]
101829822  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101829853  Jund; transcription factor jun-D [KO:K04449]
101829973  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
101830126  [KO:K16342] [EC:3.1.1.4]
101830198  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101830239  [KO:K03283]
101830284  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101830300  Irak1; interleukin-1 receptor-associated kinase 1 isoform X4 [KO:K04730] [EC:2.7.11.1]
101830366  Egf; pro-epidermal growth factor [KO:K04357]
101830519  Arrb1; beta-arrestin-1 isoform X3 [KO:K04439]
101830563  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101830625  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101830821  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101831139  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101831177  Rela; transcription factor p65 isoform X1 [KO:K04735]
101831197  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101831253  Epha2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101831283  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101831481  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101831487  Fgf18; fibroblast growth factor 18 [KO:K04358]
101831721  Fos; proto-oncogene c-Fos [KO:K04379]
101831785  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101831898  Pla2g4d; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
101832083  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101832112  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101832187  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101832263  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101832415  Pla2g4b; cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
101832477  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101832508  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
101832517  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101832672  Ntf3; neurotrophin-3 [KO:K04356]
101832748  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
101832755  Artn; artemin [KO:K25415]
101832805  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
101832971  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101833150  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101833210  Pgf; placenta growth factor [KO:K16859]
101833237  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101833242  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
101833265  [KO:K05091] [EC:2.7.10.1]
101833340  Rras2; ras-related protein R-Ras2 [KO:K07830]
101833636  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101833650  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101833656  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101833914  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101833915  Tp53; cellular tumor antigen p53 [KO:K04451]
101834034  Stmn1; stathmin [KO:K04381]
101834115  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101834159  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
101834186  Rasgrp3; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
101834246  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101834349  Ereg; proepiregulin [KO:K09784]
101834428  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X23 [KO:K04850]
101834429  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101834448  Fgf2; fibroblast growth factor 2 [KO:K18497]
101834505  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
101834560  Gadd45a; LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101834564  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101834599  Rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
101834601  Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
101834666  Efna2; ephrin-A2 [KO:K05462]
101834810  Ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
101834979  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
101835044  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
101835060  Dusp3; dual specificity protein phosphatase 3 isoform X2 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101835194  Angpt2; angiopoietin-2 [KO:K05466]
101835274  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101835364  Fgf6; fibroblast growth factor 6 [KO:K04358]
101835435  Gdnf; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
101835530  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
101835551  Mef2c; myocyte-specific enhancer factor 2C isoform X4 [KO:K04454]
101835630  Fgf23; fibroblast growth factor 23 [KO:K22428]
101835632  Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
101835661  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
101835763  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101835814  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
101835840  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101835846  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101835887  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101835896  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X3 [KO:K04434]
101835912  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101835944  Kras; GTPase KRas isoform X1 [KO:K07827]
101835994  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101836179  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X3 [KO:K04864]
101836306  Taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
101836409  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
101836565  Cacna1b; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101836768  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101836939  Taok2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
101837014  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101837015  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101837095  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
101837117  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101837200  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101837206  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101837230  Areg; amphiregulin [KO:K09782]
101837384  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
101837459  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
101837515  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101837518  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101837712  Cacna2d3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101837719  Efna1; ephrin-A1 isoform X1 [KO:K05462]
101837781  Cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
101837823  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
101837923  Fgf20; fibroblast growth factor 20 [KO:K04358]
101837924  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101837931  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
101837932  Kitlg; kit ligand isoform X1 [KO:K05461]
101837986  Efna3; ephrin-A3 isoform X1 [KO:K05462]
101838044  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101838091  Fgf19; fibroblast growth factor 19 [KO:K22603]
101838095  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101838194  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101838252  Efna4; ephrin-A4 [KO:K05462]
101838313  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101838365  Fgf4; fibroblast growth factor 4 [KO:K04358]
101838431  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101838455  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101838500  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
101838620  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101838622  Fgf3; fibroblast growth factor 3 [KO:K04358]
101838668  Cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101838741  Il1a; interleukin-1 alpha [KO:K04383]
101838749  Egfr; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101838888  Fgf10; fibroblast growth factor 10 [KO:K04358]
101838968  Hras; GTPase HRas isoform X1 [KO:K02833]
101838990  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101839008  Il1b; interleukin-1 beta [KO:K04519]
101839264  Crk; adapter molecule crk isoform X1 [KO:K04438]
101839499  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101839548  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
101839587  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101839669  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
101839736  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
101839822  Vegfa; vascular endothelial growth factor A precursor [KO:K05448]
101840143  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101840162  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101840166  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101840188  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101840210  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101840296  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101840374  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101840429  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
101840462  Sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
101840473  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
101840590  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
101840678  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101840690  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101840696  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101840885  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101840978  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
101841113  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101841299  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101841364  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101841394  Fgf22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101841668  Mapk3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101841725  Tgfbr2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101841730  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101841854  Map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
101841999  Nras; GTPase NRas isoform X1 [KO:K07828]
101842052  Flna; filamin-A isoform X1 [KO:K04437]
101842114  Map4k2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101842115  Fgf21; fibroblast growth factor 21 [KO:K22429]
101842312  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101842418  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
101842486  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
101842609  [KO:K04723]
101842691  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3 [KO:K04372] [EC:2.7.11.1]
101842724  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101842876  Sos1; son of sevenless homolog 1 [KO:K03099]
101842956  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101843009  Map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101843056  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101843397  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101843619  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101843732  Tnf; tumor necrosis factor [KO:K03156]
101843997  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101844025  Srf; serum response factor isoform X1 [KO:K04378]
101844274  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101844364  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101844417  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101844437  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101844454  Mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
101844509  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
101844616  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101844643  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
101844688  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
101844689  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
101844774  Ntf4; neurotrophin-4 [KO:K12457]
101844781  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101844833  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101844946  Hspb1; heat shock protein beta-1 [KO:K04455]
106021067  [KO:K04370]
106021596  [KO:K04358]
106021831  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110342135  Ngf; beta-nerve growth factor [KO:K02582]
110342739  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
121134227  [KO:K03283]
121134668  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
121134754  [KO:K04527] [EC:2.7.10.1]
121136483  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
121137054  [KO:K07828]
121140006  [KO:K04453]
121140148  [KO:K03283]
121140286  [KO:K04457] [EC:3.1.3.16]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
maua04070  Phosphatidylinositol signaling system
maua04110  Cell cycle
maua04115  p53 signaling pathway
maua04210  Apoptosis
maua04310  Wnt signaling pathway
maua04668  TNF signaling pathway
KO pathway
ko04010   

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