KEGG   PATHWAY: mbez04530
Entry
mbez04530                   Pathway                                
Name
Tight junction - Moschus berezovskii (Chinese forest musk deer)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mbez04530  Tight junction
mbez04530

Other DBs
GO: 0005923
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129534808  RAP2C; ras-related protein Rap-2c [KO:K07839]
129535038  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
129535911  MYL6B; myosin light chain 6B [KO:K12751]
129535913  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
129536245  [KO:K04802]
129536409  TUBA8; tubulin alpha-8 chain [KO:K07374]
129536501  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
129536741  [KO:K07374]
129536744  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
129536760  [KO:K07374]
129536761  [KO:K07374]
129536762  [KO:K07374]
129537111  MYH9; myosin-9 [KO:K10352]
129537265  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
129537514  ACTR3; actin-related protein 3 [KO:K18584]
129537783  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
129537811  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
129537982  [KO:K07374]
129538092  [KO:K07374]
129538301  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
129539125  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
129539208  [KO:K04382] [EC:3.1.3.16]
129539256  ACTR2; actin-related protein 2 [KO:K17260]
129539448  [KO:K04513]
129539650  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
129539810  [KO:K04392]
129539824  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
129540358  [KO:K12751]
129540466  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
129540524  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
129540567  RAB13; ras-related protein Rab-13 [KO:K06109]
129540610  JUN; transcription factor Jun [KO:K04448]
129540637  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129540785  [KO:K06448]
129540880  [KO:K06448]
129540918  [KO:K06448]
129540919  [KO:K06448]
129540920  [KO:K06448]
129540937  PATJ; inaD-like protein isoform X1 [KO:K06092]
129540969  F11R; junctional adhesion molecule A [KO:K06089]
129540994  [KO:K06448]
129541016  [KO:K06448]
129541046  [KO:K06448]
129541115  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
129541154  CGN; cingulin [KO:K06102]
129541434  [KO:K04353]
129541521  [KO:K06448]
129541676  CLDN19; claudin-19 [KO:K06087]
129541813  RAP1A; ras-related protein Rap-1A [KO:K04353]
129542231  NF2; merlin isoform X1 [KO:K16684]
129542356  [KO:K05757]
129542474  [KO:K04354]
129542549  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
129542567  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129542622  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
129542666  CLDN7; claudin-7 [KO:K06087]
129542695  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
129542744  CLDN5; claudin-5 [KO:K06087]
129543158  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
129543537  MYH10; myosin-10 [KO:K10352]
129543789  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
129544217  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
129544356  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129544365  CDC42; cell division control protein 42 homolog [KO:K04393]
129544460  CLDN1; claudin-1 [KO:K06087]
129544620  ACTG1; actin, cytoplasmic 2 [KO:K05692]
129544719  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
129544748  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
129545072  CLDN9; claudin-9 [KO:K06087]
129545073  CLDN6; claudin-6 [KO:K06087]
129545132  CLDN3; claudin-3 [KO:K06087]
129545401  MYH11; myosin-11 isoform X1 [KO:K10352]
129545467  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
129545616  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
129545619  CLDN4; claudin-4 [KO:K06087]
129545656  CLDN15; claudin-15 isoform X1 [KO:K06087]
129545724  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
129545729  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
129545763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129545772  ACTB; actin, cytoplasmic 1 [KO:K05692]
129545800  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
129546429  MYH14; myosin-14 isoform X1 [KO:K10352]
129546445  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
129546649  SYMPK; symplekin isoform X1 [KO:K06100]
129546665  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
129546857  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
129546935  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
129547002  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
129547313  CLDN18; claudin-18 isoform X1 [KO:K06087]
129547623  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129547932  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129547959  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
129547993  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
129548062  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
129548657  CTTN; src substrate cortactin isoform X1 [KO:K06106]
129548664  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129548934  JAM3; junctional adhesion molecule C [KO:K06785]
129548990  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
129549056  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
129549108  CLDN14; claudin-14 [KO:K06087]
129549215  CLDN22; claudin-22 [KO:K06087]
129549216  [KO:K06087]
129549360  CLDN23; claudin-23 [KO:K06087]
129549379  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
129549547  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
129549745  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
129549761  [KO:K12757]
129549763  [KO:K12757]
129549878  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
129550223  CLDN17; claudin-17 [KO:K06087]
129550328  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
129550382  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
129550615  [KO:K06090]
129550683  [KO:K07839]
129550698  CLDN16; claudin-16 [KO:K06087]
129551300  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
129551440  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
129552202  CLDN12; claudin-12 [KO:K06087]
129552417  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
129552725  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
129552775  CLDN8; claudin-8 [KO:K06087]
129552799  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
129552806  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
129553151  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
129553192  OCLN; occludin [KO:K06088]
129553196  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
129553244  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
129553297  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
129554279  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
129554308  RDX; radixin [KO:K05762]
129554318  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
129554345  CLDN25; putative claudin-25 [KO:K06087]
129554739  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
129554914  [KO:K04392]
129555368  [KO:K18584]
129555633  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129556457  CLDN10; claudin-10 [KO:K06087]
129556913  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
129557034  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
129557377  GATA4; transcription factor GATA-4 [KO:K09183]
129557434  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
129557511  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129557581  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
129557631  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
129557973  CLDN34; claudin-34 [KO:K06087]
129558084  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
129558100  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
129558238  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
129558401  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129558414  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
129558567  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
129558655  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129558855  [KO:K05755]
129558996  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
129559033  RAB8A; ras-related protein Rab-8A [KO:K07901]
129559074  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
129559239  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
129559467  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129559512  SYNPO; synaptopodin [KO:K21112]
129559971  PCNA; proliferating cell nuclear antigen [KO:K04802]
129560185  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
129560696  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129560733  BVES; blood vessel epicardial substance [KO:K21108]
129560859  EZR; ezrin [KO:K08007]
129560977  AFDN; afadin isoform X1 [KO:K05702]
129561315  CLDN20; claudin-20 [KO:K06087]
129561625  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
129562057  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
129562449  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
129562471  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
129562565  RAB8B; ras-related protein Rab-8B [KO:K07902]
129562720  PALS1; protein PALS1 isoform X1 [KO:K06091]
129563114  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
129563196  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
129563285  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129563548  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
129563803  [KO:K03456]
129563804  [KO:K03456]
129564131  MSN; moesin [KO:K05763]
129564222  [KO:K04382] [EC:3.1.3.16]
129564254  AMOT; angiomotin isoform X1 [KO:K16819]
129564289  CLDN2; claudin-2 [KO:K06087]
129564332  WAS; actin nucleation-promoting factor WAS [KO:K05747]
129564388  DLG3; disks large homolog 3 [KO:K21098]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mbez04520  Adherens junction
mbez04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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