KEGG   PATHWAY: mbez04810
Entry
mbez04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Moschus berezovskii (Chinese forest musk deer)
Class
Cellular Processes; Cell motility
Pathway map
mbez04810  Regulation of actin cytoskeleton
mbez04810

Other DBs
GO: 0030036
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129557044  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
129559073  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
129534915  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
129535685  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
129555606  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
129538394  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
129554803  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
129563109  F2R; proteinase-activated receptor 1 [KO:K03914]
129548407  INS; insulin [KO:K04526]
129561712  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
129559536  FGF1; fibroblast growth factor 1 [KO:K18496]
129542296  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129555960  FGF8; fibroblast growth factor 8 [KO:K04358]
129556389  FGF9; fibroblast growth factor 9 [KO:K04358]
129549223  FGF20; fibroblast growth factor 20 [KO:K04358]
129557346  FGF17; fibroblast growth factor 17 [KO:K04358]
129537016  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
129559049  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
129553142  FGF18; fibroblast growth factor 18 [KO:K04358]
129553277  FGF10; fibroblast growth factor 10 [KO:K04358]
129562082  FGF5; fibroblast growth factor 5 [KO:K04358]
129562501  FGF7; fibroblast growth factor 7 [KO:K04358]
129534906  FGF16; fibroblast growth factor 16 [KO:K04358]
129548662  FGF3; fibroblast growth factor 3 [KO:K04358]
129548663  FGF4; fibroblast growth factor 4 [KO:K04358]
129548328  FGF19; fibroblast growth factor 19 [KO:K22603]
129546182  FGF21; fibroblast growth factor 21 [KO:K22429]
129536537  FGF23; fibroblast growth factor 23 [KO:K22428]
129545815  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
129536369  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129542873  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
129554238  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129540752  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
129548207  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129549407  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129555293  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129561939  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129559284  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
129562088  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129558396  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129537610  FN1; fibronectin isoform X1 [KO:K05717]
129553271  ITGA1; integrin alpha-1 [KO:K06480]
129553269  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
129544490  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
129544270  ITGA3; integrin alpha-3 [KO:K06482]
129538089  ITGA4; integrin alpha-4 [KO:K06483]
129535852  ITGA5; integrin alpha-5 [KO:K06484]
129538654  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
129535732  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
129558269  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
129548149  ITGA9; integrin alpha-9 [KO:K06585]
129540534  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
129563190  ITGA11; integrin alpha-11 [KO:K06587]
129538673  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
129545532  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
129545565  ITGAM; integrin alpha-M [KO:K06461]
129545566  ITGAX; integrin alpha-X [KO:K06462]
129545567  ITGAD; integrin alpha-D [KO:K06594]
129541712  ITGAE; integrin alpha-E [KO:K06524]
129557511  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129548626  ITGB2; integrin beta-2 [KO:K06464]
129544525  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
129544714  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
129537587  ITGB5; integrin beta-5 [KO:K06588]
129538496  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
129537242  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
129552289  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
129550727  KNG1; kininogen-1 isoform X1 [KO:K03898]
129550629  B1 bradykinin receptor isoform X1 [KO:K03915]
129548449  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129552682  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
129555841  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
129554066  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
129563413  muscarinic acetylcholine receptor M5-like [KO:K04133]
129562455  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M5-like [KO:K04133]
129557216  C5; complement C5 [KO:K03994]
129553056  C6; complement component C6 [KO:K03995]
129553094  C7; complement component C7 [KO:K03996]
129541700  C8A; complement component C8 alpha chain [KO:K03997]
129541518  C8B; complement component C8 beta chain [KO:K03998]
129539174  C8G; complement component C8 gamma chain [KO:K03999]
129553303  C9; complement component C9 [KO:K04000]
129545783  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
129544787  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
129558470  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129564466  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
129557004  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
129559901  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129547261  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
129542494  CRKL; crk-like protein [KO:K04438]
129541258  CRK; adapter molecule crk isoform X1 [KO:K04438]
129555249  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
129563285  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129539931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129562678  SOS2; son of sevenless homolog 2 [KO:K03099]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129541808  NRAS; GTPase NRas [KO:K07828]
129546539  RRAS; ras-related protein R-Ras [KO:K07829]
129554492  RRAS2; ras-related protein R-Ras2 [KO:K07830]
129547251  MRAS; ras-related protein M-Ras [KO:K07831]
129564210  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129559031  VAV1; proto-oncogene vav [KO:K05730]
129539945  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
129540618  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
129552725  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
129564326  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129552712  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129559820  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129558523  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129556225  RGCC; regulator of cell cycle RGCC [KO:K26108]
129546759  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
129554443  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
129546625  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
129539448  transforming protein RhoA-like [KO:K04513]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129545763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129539810  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129554914  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129536787  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
129544591  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
129544365  CDC42; cell division control protein 42 homolog [KO:K04393]
129549029  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129542500  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
129535252  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
129546841  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
129556249  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
129562886  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
129556518  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
129540948  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
129549745  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
129539650  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
129543225  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
129536830  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
129547136  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
129562134  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
129542802  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129537845  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129539892  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129548700  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
129536404  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
129551173  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
129545961  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
129542695  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
129552089  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
129563114  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
129545141  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
129549761  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
129549763  myosin regulatory light chain 12B [KO:K12757]
129545529  MYL11; myosin regulatory light chain 11 [KO:K12758]
129543537  MYH10; myosin-10 [KO:K10352]
129537111  MYH9; myosin-9 [KO:K10352]
129545401  MYH11; myosin-11 isoform X1 [KO:K10352]
129546429  MYH14; myosin-14 isoform X1 [KO:K10352]
129558488  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
129564350  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
129537871  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
129557632  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
129558539  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
129541834  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
129535946  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
129556587  phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
129557614  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
129544332  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
129537633  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
129545614  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
129542806  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
129556209  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
129544628  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
129551641  ENAH; protein enabled homolog isoform X1 [KO:K05746]
129552611  WASL; actin nucleation-promoting factor WASL [KO:K23612]
129537532  WASF2; actin-binding protein WASF2 isoform X1 [KO:K05748]
129558712  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
129538410  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
129536662  NCKAP1L; nck-associated protein 1-like [KO:K05750]
129538643  NCKAP1; nck-associated protein 1 [KO:K05750]
129538231  ABI2; abl interactor 2 isoform X1 [KO:K05751]
129548073  BRK1; protein BRICK1 [KO:K05752]
129561219  WASF1; actin-binding protein WASF1 [KO:K05753]
129539256  ACTR2; actin-related protein 2 [KO:K17260]
129537514  ACTR3; actin-related protein 3 [KO:K18584]
129552806  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
129555368  actin-related protein 3-like [KO:K18584]
129542356  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
129545724  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
129545729  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
129537783  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
129542567  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129558855  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
129548062  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
129551300  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
129539125  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
129544620  ACTG1; actin, cytoplasmic 2 [KO:K05692]
129545772  ACTB; actin, cytoplasmic 1 [KO:K05692]
129542386  PFN1; profilin-1 [KO:K05759]
129557993  PFN3; profilin-3 [KO:K05759]
129539497  PFN4; profilin-4 [KO:K05759]
129546688  PFN2; profilin-2 isoform X1 [KO:K05759]
129535070  profilin-1-like [KO:K05759]
129542185  PXN; paxillin isoform X1 [KO:K05760]
129560859  EZR; ezrin [KO:K08007]
129554308  RDX; radixin [KO:K05762]
129564131  MSN; moesin [KO:K05763]
129550510  CFL2; cofilin-2 isoform X1 [KO:K05765]
129548757  CFL1; cofilin-1 [KO:K05765]
129541017  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
129542234  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
129548705  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
129555693  VCL; vinculin isoform X1 [KO:K05700]
129550312  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
129541472  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
129562583  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
129557219  GSN; gelsolin isoform X1 [KO:K05768]
129552263  SCIN; scinderin [KO:K05768]
129563548  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
129546857  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
129563180  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
129559054  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
129556382  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
129538132  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mbez04010  MAPK signaling pathway
mbez04510  Focal adhesion
mbez04520  Adherens junction
KO pathway
ko04810   
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