KEGG   PATHWAY: mmur00260
Entry
mmur00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Microcebus murinus (gray mouse lemur)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mmur00260  Glycine, serine and threonine metabolism
mmur00260

Module
mmur_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mmur00260]
mmur_M00047  Creatine pathway [PATH:mmur00260]
mmur_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mmur00260]
mmur_M00555  Betaine biosynthesis, choline => betaine [PATH:mmur00260]
mmur_M00621  Glycine cleavage system [PATH:mmur00260]
mmur_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mmur00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105854886  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
105856546  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
105857923  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
105857960  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
105858405  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
105858586  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
105859448  AOC3; membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
105859450  [KO:K00276] [EC:1.4.3.21]
105859452  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
105860194  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
105860518  [KO:K02437]
105860790  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
105860915  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
105861205  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
105861976  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
105862242  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
105862403  [KO:K02437]
105864381  SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105864384  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105864822  [KO:K15789] [EC:1.1.1.103]
105865457  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
105865458  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
105866433  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
105866990  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
105867781  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
105868713  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
105869789  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
105871020  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
105872561  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
105872621  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X2 [KO:K00315] [EC:1.5.8.4]
105872623  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
105873112  PGAM1; LOW QUALITY PROTEIN: phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
105873817  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
105874959  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
105875039  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
105875042  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
105875076  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
105875835  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
105877969  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
105879116  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
105880753  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
105884227  [KO:K01758] [EC:4.4.1.1]
105884239  [KO:K01758] [EC:4.4.1.1]
105884242  [KO:K01758] [EC:4.4.1.1]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mmur00010  Glycolysis / Gluconeogenesis
mmur00020  Citrate cycle (TCA cycle)
mmur00230  Purine metabolism
mmur00250  Alanine, aspartate and glutamate metabolism
mmur00270  Cysteine and methionine metabolism
mmur00290  Valine, leucine and isoleucine biosynthesis
mmur00330  Arginine and proline metabolism
mmur00470  D-Amino acid metabolism
mmur00564  Glycerophospholipid metabolism
mmur00600  Sphingolipid metabolism
mmur00620  Pyruvate metabolism
mmur00630  Glyoxylate and dicarboxylate metabolism
mmur00640  Propanoate metabolism
mmur00860  Porphyrin metabolism
mmur00920  Sulfur metabolism
KO pathway
ko00260   

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