KEGG   PATHWAY: mmur04310
Entry
mmur04310                   Pathway                                
Name
Wnt signaling pathway - Microcebus murinus (gray mouse lemur)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmur04310  Wnt signaling pathway
mmur04310

Other DBs
GO: 0016055
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105855352  TLE1; transducin-like enhancer protein 1 isoform X1 [KO:K04497]
105855775  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105856263  AXIN1; axin-1 isoform X1 [KO:K02157]
105856379  PORCN; protein-serine O-palmitoleoyltransferase porcupine isoform X1 [KO:K00181] [EC:2.3.1.250]
105856416  PRICKLE3; prickle-like protein 3 isoform X1 [KO:K04511]
105856891  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308]
105856944  FZD7; frizzled-7 [KO:K02432]
105857146  CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
105857150  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105857652  WNT10A; protein Wnt-10a [KO:K01357]
105857713  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
105857929  NLK; serine/threonine-protein kinase NLK isoform X2 [KO:K04468] [EC:2.7.11.24]
105857966  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105857987  SERPINF1; pigment epithelium-derived factor [KO:K19614]
105858130  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
105858213  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
105858406  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105858435  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
105858544  CBY1; protein chibby homolog 1 [KO:K23402]
105858549  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
105858560  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105858613  [KO:K08960] [EC:2.7.11.1]
105858813  FZD9; frizzled-9 [KO:K02842]
105858914  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105859051  [KO:K04497]
105859673  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
105859740  PRICKLE1; prickle-like protein 1 [KO:K04511]
105859799  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
105859877  [KO:K05128] [EC:2.7.10.1]
105860061  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399]
105860097  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105860140  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
105860401  WNT11; protein Wnt-11 [KO:K01384]
105860427  FZD4; frizzled-4 [KO:K02354]
105860762  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
105861025  APCDD1; protein APCDD1 [KO:K25812]
105861219  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105861399  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
105861590  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105861618  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105861654  AXIN2; axin-2 isoform X1 [KO:K04385]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105862086  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
105862521  WNT8A; protein Wnt-8a isoform X3 [KO:K00714]
105862673  VANGL2; vang-like protein 2 [KO:K04510]
105863012  TLE4; transducin-like enhancer protein 4 isoform X1 [KO:K04497]
105863066  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
105863245  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105863295  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105863624  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105863673  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105864291  [KO:K04440] [EC:2.7.11.24]
105864316  FZD5; frizzled-5 [KO:K02375]
105864522  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
105864659  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
105864858  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105864868  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
105864876  [KO:K04499] [EC:5.6.2.4]
105865198  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
105865754  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105865794  RSPO4; R-spondin-4 isoform X1 [KO:K23099]
105865954  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105866622  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105867344  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
105867353  WNT16; protein Wnt-16 [KO:K01558]
105867396  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
105867511  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105868254  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105868496  WNT10B; protein Wnt-10b [KO:K01357]
105868798  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105868864  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
105869202  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105869373  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
105869755  VANGL1; vang-like protein 1 [KO:K04510]
105869975  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
105869977  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
105870235  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
105870298  DKK1; dickkopf-related protein 1 [KO:K02165]
105870851  MCC; colorectal mutant cancer protein isoform X2 [KO:K26734]
105870856  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
105870897  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [KO:K16273] [EC:2.3.2.27]
105871264  RNF43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
105871442  GPC4; glypican-4 [KO:K08110]
105871644  CACYBP; calcyclin-binding protein isoform X1 [KO:K04507]
105871854  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
105871982  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
105872262  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105872329  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
105872433  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
105872654  RYK; tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
105872762  FZD10; frizzled-10 [KO:K02842]
105872813  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122] [EC:2.7.10.1]
105873000  FRAT1; proto-oncogene FRAT1 [KO:K03069]
105873009  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
105873184  SFRP5; secreted frizzled-related protein 5 [KO:K02222]
105873323  CUL1; cullin-1 [KO:K03347]
105873410  TLE3; transducin-like enhancer protein 3 isoform X1 [KO:K04497]
105873607  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
105873639  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
105873751  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105873772  INVS; inversin isoform X1 [KO:K19626]
105873787  LZTS2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471]
105873824  [KO:K04507]
105873891  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
105873967  TLE2; transducin-like enhancer protein 2 isoform X1 [KO:K04497]
105873969  TLE6; transducin-like enhancer protein 6 [KO:K04497]
105874146  CER1; cerberus [KO:K01645]
105874233  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
105874271  PRICKLE2; LOW QUALITY PROTEIN: prickle-like protein 2 [KO:K04511]
105874413  CTNNB1; catenin beta-1 [KO:K02105]
105874547  APCDD1L; protein APCDD1-like [KO:K25812]
105874595  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
105874723  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105874790  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105874961  RHOA; transforming protein RhoA [KO:K04513]
105875160  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
105875858  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105875861  PRICKLE4; prickle-like protein 4 isoform X1 [KO:K04511]
105876190  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
105876282  CCDC88C; protein Daple isoform X1 [KO:K25811]
105876478  NKD2; protein naked cuticle homolog 2 [KO:K03213]
105876584  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
105877164  FZD3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
105877486  TP53; cellular tumor antigen p53 [KO:K04451]
105877644  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
105877972  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105878067  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105878146  DKK4; dickkopf-related protein 4 isoform X1 [KO:K02165]
105878164  SFRP1; secreted frizzled-related protein 1 [KO:K02166]
105878190  RSPO3; R-spondin-3 [KO:K23098]
105878249  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
105878468  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105878550  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
105878605  DAAM2; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 2 [KO:K04512]
105878754  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105878831  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
105879042  CXXC4; CXXC-type zinc finger protein 4 isoform X2 [KO:K03344]
105879065  DKK2; dickkopf-related protein 2 isoform X1 [KO:K02165]
105879391  FZD1; frizzled-1 [KO:K02432]
105879489  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
105879531  RSPO1; R-spondin-1 [KO:K19471]
105879718  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105879917  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105880040  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105880217  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105880362  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
105880938  WIF1; wnt inhibitory factor 1 [KO:K01691]
105881021  TBL1X; F-box-like/WD repeat-containing protein TBL1X isoform X2 [KO:K04508]
105881031  [KO:K04513]
105881062  [KO:K01064]
105881459  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105881649  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
105881785  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
105882153  FZD6; frizzled-6 isoform X1 [KO:K02376]
105882585  JUN; transcription factor AP-1 [KO:K04448]
105882748  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
105882775  WISP1; WNT1-inducible-signaling pathway protein 1 isoform X1 [KO:K22471]
105882918  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
105882996  FRZB; secreted frizzled-related protein 3 [KO:K25481]
105883271  RSPO2; R-spondin-2 isoform X1 [KO:K23097]
105883515  WNT9B; protein Wnt-9b [KO:K01064]
105883518  SOST; sclerostin [KO:K16834]
105883521  FZD2; frizzled-2 [KO:K02235]
105883746  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105884666  BAMBI; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162]
105884723  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105884742  NKD1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
105884763  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
105884893  SOX17; transcription factor SOX-17 [KO:K04495]
105884941  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM isoform X1 [KO:K19882] [EC:3.1.1.98]
105885376  CTNND2; catenin delta-2 isoform X1 [KO:K23491]
105885735  [KO:K04515] [EC:2.7.11.17]
105885935  [KO:K04499] [EC:5.6.2.4]
109730641  LRP5L; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like protein [KO:K03068]
Compound
C00076  Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
mmur04010  MAPK signaling pathway
mmur04110  Cell cycle
mmur04115  p53 signaling pathway
mmur04120  Ubiquitin mediated proteolysis
mmur04350  TGF-beta signaling pathway
mmur04510  Focal adhesion
mmur04520  Adherens junction
mmur05010  Alzheimer disease
KO pathway
ko04310   

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