KEGG   PATHWAY: mmur04010
Entry
mmur04010                   Pathway                                
Name
MAPK signaling pathway - Microcebus murinus (gray mouse lemur)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmur04010  MAPK signaling pathway
mmur04010

Other DBs
GO: 0000165
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105854849  [KO:K03283]
105854850  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105854933  DUSP10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105854966  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
105854982  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
105855469  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105855508  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105856032  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105856318  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105856433  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105856510  MAP3K21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
105856557  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105856565  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105856794  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105856828  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105857128  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105857150  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105857227  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105857286  KRAS; GTPase KRas isoform X1 [KO:K07827]
105857327  NF1; neurofibromin isoform X1 [KO:K08052]
105857534  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X2 [KO:K04420] [EC:2.7.11.25]
105857795  FGF10; fibroblast growth factor 10 [KO:K04358]
105857831  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
105857833  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105857910  CRK; adapter molecule crk isoform X1 [KO:K04438]
105857929  NLK; serine/threonine-protein kinase NLK isoform X2 [KO:K04468] [EC:2.7.11.24]
105857940  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105858137  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105858167  [KO:K03283]
105858168  [KO:K03283]
105858431  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105858450  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105858508  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105858532  [KO:K04856]
105858535  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105858625  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105858761  PGF; placenta growth factor isoform X1 [KO:K16859]
105858849  FOS; proto-oncogene c-Fos [KO:K04379]
105858897  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105858898  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
105858914  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105858956  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
105859037  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105859190  IL1B; interleukin-1 beta [KO:K04519]
105859191  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
105859583  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
105859586  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
105859821  IGF2; insulin-like growth factor II [KO:K13769]
105859822  INS; insulin [KO:K04526]
105859992  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105860052  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
105860097  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105860148  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105860213  AREG; amphiregulin isoform X1 [KO:K09782]
105860338  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105860366  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
105860441  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
105860447  EREG; proepiregulin [KO:K09784]
105860751  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
105860779  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
105860843  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105861093  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105861389  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105861390  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105861596  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105861600  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105861618  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105861627  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105861650  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105861678  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105861681  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105861717  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105861723  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105862003  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105862174  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105862190  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
105862314  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105862389  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
105862501  FGF1; fibroblast growth factor 1 [KO:K18496]
105862649  [KO:K04391]
105862669  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105863058  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105863245  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105863259  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105863295  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105863430  STMN1; stathmin [KO:K04381]
105863478  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
105863518  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105863624  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105863664  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105863738  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105864049  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105864291  [KO:K04440] [EC:2.7.11.24]
105865027  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105865052  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105865376  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105865604  NTF4; neurotrophin-4 [KO:K12457]
105865609  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105865643  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
105865679  FGF21; fibroblast growth factor 21 [KO:K22429]
105865754  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105865757  FLT4; vascular endothelial growth factor receptor 3 isoform X6 [KO:K05097] [EC:2.7.10.1]
105866002  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
105866027  ANGPT4; angiopoietin-4 [KO:K05467]
105866146  FGF16; fibroblast growth factor 16 [KO:K04358]
105866663  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
105866714  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
105866806  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105866861  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
105867131  [KO:K04467] [EC:2.7.11.10]
105867172  FGF18; fibroblast growth factor 18 [KO:K04358]
105867330  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105867336  DUSP9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
105867398  FGF19; fibroblast growth factor 19 [KO:K22603]
105867400  FGF3; fibroblast growth factor 3 [KO:K04358]
105867413  FGF4; fibroblast growth factor 4 [KO:K04358]
105867609  KITLG; kit ligand isoform X1 [KO:K05461]
105867678  SOS2; son of sevenless homolog 2 [KO:K03099]
105867801  FLNA; filamin-A isoform X1 [KO:K04437]
105867816  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105867837  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105867839  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105867869  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105867910  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105868083  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105868254  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105868355  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105868391  HSPB1; heat shock protein beta-1 [KO:K04455]
105868406  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105868604  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
105868645  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105868760  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105868798  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105868808  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105869016  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105869061  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105869115  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
105869368  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105869516  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
105869563  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
105869651  NRTN; neurturin [KO:K25414]
105869670  PSPN; persephin [KO:K25416]
105869687  [KO:K04527] [EC:2.7.10.1]
105869885  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
105870086  RASA2; ras GTPase-activating protein 2 [KO:K08053]
105870310  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105870403  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105870487  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105870697  [KO:K04371] [EC:2.7.11.24]
105870727  FGF7; fibroblast growth factor 7 [KO:K04358]
105870789  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
105870804  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105871108  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105871124  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105871174  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105871266  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105871657  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105871667  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105871862  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105872099  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105872117  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
105872305  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105872414  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
105872489  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
105872491  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105872495  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
105872576  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105872641  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
105872856  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105872857  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105873105  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105873179  EFNA1; ephrin-A1 [KO:K05462]
105873186  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105873187  EFNA4; ephrin-A4 [KO:K05462]
105873244  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105873441  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105873508  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105873559  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
105873610  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105873751  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105873781  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105873938  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105873977  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105873984  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105874032  HRAS; GTPase HRas [KO:K02833]
105874062  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105874199  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105874557  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105874668  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
105874719  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
105874720  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
105874722  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105874723  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105874790  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105874819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105874924  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105875001  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X6 [KO:K04859]
105875013  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
105875037  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105875072  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105875382  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
105875567  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105875827  SRF; serum response factor isoform X1 [KO:K04378]
105875869  VEGFA; vascular endothelial growth factor A [KO:K05448]
105876174  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105876284  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
105876697  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105876768  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105876773  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
105876826  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
105876828  RASGRP4; RAS guanyl-releasing protein 4 isoform X3 [KO:K12363]
105877217  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105877272  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
105877427  ARTN; artemin isoform X1 [KO:K25415]
105877486  TP53; cellular tumor antigen p53 [KO:K04451]
105877503  MOB3C; MOB kinase activator 3C isoform X1 [KO:K04372] [EC:2.7.11.1]
105877776  CRKL; crk-like protein [KO:K04438]
105877796  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105877858  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105877984  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105878067  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105878144  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105878202  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105878304  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
105878355  MAX; protein max isoform X1 [KO:K04453]
105878471  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105878482  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
105878487  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
105878490  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
105878530  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
105878531  RELA; transcription factor p65 isoform X1 [KO:K04735]
105878702  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
105878704  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105878710  NRAS; GTPase NRas [KO:K07828]
105878770  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
105878875  FGF9; fibroblast growth factor 9 [KO:K04358]
105878936  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105879007  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105879179  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
105879284  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
105879323  CACNA2D1; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
105879346  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105879502  [KO:K04360] [EC:2.7.10.1]
105879602  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
105879717  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105879718  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105879808  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105879873  STK4; serine/threonine-protein kinase 4 [KO:K04411]
105879952  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105880000  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105880427  RASA1; ras GTPase-activating protein 1 [KO:K04352]
105880434  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105880624  [KO:K02187] [EC:3.4.22.56]
105880734  MAP3K20; mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
105880992  RAP1B; ras-related protein Rap-1b [KO:K07836]
105881438  NTF3; neurotrophin-3 [KO:K04356]
105881454  FGF6; fibroblast growth factor 6 [KO:K04358]
105881457  FGF23; fibroblast growth factor 23 [KO:K22428]
105881507  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105881767  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105882068  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105882072  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
105882232  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105882282  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105882367  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
105882414  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
105882502  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
105882525  FGF20; fibroblast growth factor 20 [KO:K04358]
105882585  JUN; transcription factor AP-1 [KO:K04448]
105882676  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105882748  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
105883274  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105883482  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105883528  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105883589  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105883630  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105883719  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105883746  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105883785  [KO:K04360] [EC:2.7.10.1]
105883822  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105884482  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105884529  SOS1; son of sevenless homolog 1 [KO:K03099]
105884530  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105884642  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X2 [KO:K04458] [EC:3.1.3.48]
105884723  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105884788  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
105884926  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105884995  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
105885016  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105885017  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105885093  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105885120  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105885170  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105885267  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
105885349  EFNA5; ephrin-A5 [KO:K05462]
105885431  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105885526  [KO:K04347]
105885556  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
105885655  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105885994  DAXX; death domain-associated protein 6 [KO:K02308]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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Tanoue T, Nishida E.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mmur04070  Phosphatidylinositol signaling system
mmur04110  Cell cycle
mmur04115  p53 signaling pathway
mmur04210  Apoptosis
mmur04310  Wnt signaling pathway
mmur04668  TNF signaling pathway
KO pathway
ko04010   

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