KEGG   PATHWAY: mtr03430
Entry
mtr03430                    Pathway                                
Name
Mismatch repair - Medicago truncatula (barrel medic)
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
mtr03430  Mismatch repair
mtr03430

Other DBs
GO: 0006298
Organism
Medicago truncatula (barrel medic) [GN:mtr]
Gene
25493177  endonuclease MutS2 [KO:K07456]
11446584  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
11414900  DNA mismatch repair protein PMS1 [KO:K10858]
11419396  DNA mismatch repair protein MLH1 [KO:K08734]
11432526  DNA mismatch repair protein MSH6 [KO:K08737]
11436735  DNA mismatch repair protein MSH7 isoform X1 [KO:K08737]
25493936  DNA mismatch repair protein MSH2 [KO:K08735]
25485081  DNA mismatch repair protein MSH3 isoform X3 [KO:K08736]
11424785  DNA mismatch repair protein MLH3 isoform X1 [KO:K08739]
25492173  replication factor C subunit 1 isoform X1 [KO:K10754]
11414806  replication factor C subunit 2 [KO:K10755]
25493662  replication factor C subunit 2 [KO:K10755]
11414029  replication factor C subunit 3 [KO:K10756]
11429308  uncharacterized protein LOC11429308 [KO:K10756]
120575764  uncharacterized protein LOC120575764 [KO:K10756]
25495823  replication factor C subunit 3 [KO:K10756]
25497284  replication factor C subunit 3 [KO:K10756]
25490757  proliferating cell nuclear antigen [KO:K04802]
11411391  exonuclease 1 isoform X1 [KO:K10746] [EC:3.1.-.-]
25480322  exonuclease 1 [KO:K10746] [EC:3.1.-.-]
112421905  replication protein A 70 kDa DNA-binding subunit E-like [KO:K07466]
25486480  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
25493890  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
11446020  replication protein A 32 kDa subunit B [KO:K10739]
25481878  replication protein A 32 kDa subunit A [KO:K10739]
11433064  replication protein A 14 kDa subunit B [KO:K10740]
25485573  replication protein A 14 kDa subunit B [KO:K10740]
25485575  replication protein A 14 kDa subunit B [KO:K10740]
25489857  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
11437014  DNA polymerase delta small subunit [KO:K02328]
11408397  DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
25485289  DNA polymerase delta subunit 4 [KO:K03505]
25493347  DNA polymerase delta subunit 4 [KO:K03505]
25493349  DNA polymerase delta subunit 4 [KO:K03505]
25492370  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   
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