KEGG   PATHWAY: mze04530
Entry
mze04530                    Pathway                                
Name
Tight junction - Maylandia zebra (zebra mbuna)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mze04530  Tight junction
mze04530

Other DBs
GO: 0005923
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101469310  crb3; protein crumbs homolog 3 [KO:K06090]
101480506  claudin-34-like [KO:K06087]
101474523  claudin-34 [KO:K06087]
101467212  claudin-20-like [KO:K06087]
101471808  cldn1; claudin-1 [KO:K06087]
101476761  cldn15; claudin-15 [KO:K06087]
101480519  claudin-22-like [KO:K06087]
101466930  claudin-15-like [KO:K06087]
101484678  claudin-11 [KO:K06087]
101468184  putative claudin-24 [KO:K06087]
101478021  claudin-4 [KO:K06087]
101474931  claudin-3 [KO:K06087]
101475220  claudin-4 [KO:K06087]
101475517  claudin-4-like [KO:K06087]
101475811  claudin-like protein ZF-A89 [KO:K06087]
101476102  claudin-4-like [KO:K06087]
101476402  claudin-4 [KO:K06087]
101476694  claudin-4 [KO:K06087]
101476967  claudin-4 [KO:K06087]
101477532  claudin-4 [KO:K06087]
101464480  claudin-10-like [KO:K06087]
101482102  claudin-1 [KO:K06087]
101477346  claudin-7-A [KO:K06087]
101470882  claudin-15 [KO:K06087]
101479693  claudin-7 [KO:K06087]
101479976  claudin-7 [KO:K06087]
101475321  claudin-10-like [KO:K06087]
101487438  claudin-18 [KO:K06087]
101464771  claudin-10-like [KO:K06087]
101475910  putative claudin-24 [KO:K06087]
111500471  claudin-4-like [KO:K06087]
101476361  claudin-23 [KO:K06087]
101474206  claudin-4-like [KO:K06087]
101487218  cldn20; claudin-20 [KO:K06087]
101472769  claudin-23 [KO:K06087]
101483902  claudin-11 [KO:K06087]
101479565  claudin-9 [KO:K06087]
101464691  claudin-4-like [KO:K06087]
101464975  claudin-4 [KO:K06087]
101465540  claudin-like protein ZF-A89 [KO:K06087]
101465844  claudin-4 [KO:K06087]
101466132  claudin-4-like [KO:K06087]
101466430  claudin-4 [KO:K06087]
101466714  claudin-4 [KO:K06087]
101466978  claudin-4 [KO:K06087]
101480961  claudin-4-like [KO:K06087]
101477941  claudin-9 isoform X1 [KO:K06087]
101474481  claudin-4-like [KO:K06087]
101474755  claudin-4 [KO:K06087]
101478567  cldn5; claudin-5 [KO:K06087]
101465576  cldn19; claudin-19 isoform X1 [KO:K06087]
101476456  claudin-7-A [KO:K06087]
101478235  claudin-10 [KO:K06087]
101478697  claudin-10 [KO:K06087]
101478982  claudin-10 [KO:K06087]
101465004  claudin-4 [KO:K06087]
101475074  claudin-17-like [KO:K06087]
101475374  claudin-8 [KO:K06087]
101475679  claudin-8 [KO:K06087]
101466907  cldn14; claudin-14 [KO:K06087]
101485282  cldn18; claudin-18 isoform X1 [KO:K06087]
101476999  claudin-4 [KO:K06087]
101475580  putative claudin-24 [KO:K06087]
112435429  claudin-like protein ZF-A89 [KO:K06087]
106674735  claudin-4-like [KO:K06087]
101483656  claudin-4-like [KO:K06087]
101468748  cldn12; claudin-12 [KO:K06087]
101478732  occludin [KO:K06088]
101467281  occludin-like [KO:K06088]
101482283  occludin [KO:K06088]
101486797  occludin [KO:K06088]
101469025  junctional adhesion molecule A [KO:K06089]
101470709  junctional adhesion molecule B isoform X2 [KO:K06735]
101473917  jam2; junctional adhesion molecule B isoform X1 [KO:K06735]
101482968  junctional adhesion molecule C [KO:K06785]
101483983  jam3; junctional adhesion molecule C [KO:K06785]
101473898  bves; blood vessel epicardial substance [KO:K21108]
101465436  cell division control protein 42 homolog [KO:K04393]
101466111  cell division control protein 42 homolog [KO:K04393]
101466863  cell division control protein 42 homolog [KO:K04393]
101480754  cell division control protein 42 homolog isoform X2 [KO:K04393]
101479607  cell division control protein 42 homolog [KO:K04393]
101472760  cell division control protein 42 homolog [KO:K04393]
112430189  cdc42 homolog [KO:K04393]
101474065  pard6b; partitioning defective 6 homolog beta [KO:K06093]
101479882  partitioning defective 6 homolog gamma [KO:K06093]
101478411  partitioning defective 6 homolog alpha [KO:K06093]
101480561  MAGUK p55 subfamily member 5-A [KO:K06091]
101463723  mpp5; MAGUK p55 subfamily member 5 [KO:K06091]
112430098  LOW QUALITY PROTEIN: MAGUK p55 subfamily member 5-A-like [KO:K06091]
101480945  mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
101485345  MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
101470325  tight junction protein ZO-3 isoform X1 [KO:K06097]
101479634  patj; inaD-like protein isoform X1 [KO:K06092]
101483321  multiple PDZ domain protein isoform X1 [KO:K06095]
101464141  mpdz; multiple PDZ domain protein isoform X1 [KO:K06095]
101487335  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
101482448  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
101478708  angiomotin isoform X1 [KO:K16819]
101478356  angiomotin-like 2a [KO:K06104]
101477470  amotl2; angiomotin-like protein 2 [KO:K06104]
101469212  arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
101468818  rho GTPase-activating protein 17 isoform X1 [KO:K20638]
101483895  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105941067  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101485378  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101485652  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101464944  merlin [KO:K16684]
101487922  merlin [KO:K16684]
101483678  llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
101466434  llgl2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
101473605  dlg1; disks large homolog 1 isoform X1 [KO:K12076]
101468517  disks large homolog 1 isoform X1 [KO:K12076]
101487839  scrib; protein scribble homolog isoform X1 [KO:K16175]
101470047  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101479611  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101487597  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101483438  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101464647  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
101476780  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101471900  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101484002  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101479585  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101482706  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101476097  partitioning defective 3 homolog [KO:K04237]
101463582  partitioning defective 3 homolog isoform X1 [KO:K04237]
101482226  T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101474606  tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101471045  tight junction protein ZO-1 isoform X2 [KO:K05701]
101477899  tight junction protein ZO-1 isoform X1 [KO:K05701]
101472043  tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
101476751  disks large homolog 2 isoform X1 [KO:K12075]
101479027  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
101487985  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101477833  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
101483907  cgn; cingulin [KO:K06102]
101475830  cingulin isoform X1 [KO:K06102]
101466296  cgnl1; cingulin-like protein 1 [KO:K21110]
101478167  cingulin-like protein 1 [KO:K21110]
101464628  rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
101482012  rho guanine nucleotide exchange factor 2 [KO:K12791]
101485690  rho-related GTP-binding protein RhoA-B [KO:K04513]
101478838  rho-related GTP-binding protein RhoA-C [KO:K04513]
101472412  rho-related GTP-binding protein RhoA-D [KO:K04513]
101464339  rho-related GTP-binding protein RhoA-C [KO:K04513]
101465971  rho-related GTP-binding protein RhoA-B [KO:K04513]
101481014  gata4; transcription factor GATA-4 [KO:K09183]
101473961  marveld3; MARVEL domain-containing protein 3 [KO:K21099]
101463618  MARVEL domain-containing protein 3 [KO:K21099]
101480702  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101486303  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101477577  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101476882  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101463670  transcription factor AP-1 [KO:K04448]
101486839  jun; transcription factor AP-1 [KO:K04448]
101472459  transcription factor AP-1 [KO:K04448]
101473042  cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101475315  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101479833  sympk; symplekin [KO:K06100]
101482883  pcna; proliferating cell nuclear antigen [KO:K04802]
101485361  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101467298  G1/S-specific cyclin-D1 [KO:K04503]
101482712  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101482179  runt-related transcription factor 1 [KO:K08367]
101467637  heat shock 70 kDa protein 4 [KO:K09489]
101485811  heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101485040  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101475468  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101468243  ezrin [KO:K08007]
101480288  ezr; ezrin [KO:K08007]
101469272  radixin [KO:K05762]
101478951  radixin [KO:K05762]
101465591  moesin isoform X1 [KO:K05763]
101465099  moesin isoform X1 [KO:K05763]
101486794  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
101468101  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
101487522  actin, cytoplasmic 1 [KO:K05692]
101470738  actb; actin, cytoplasmic 1 [KO:K05692]
101464190  actin, cytoplasmic 2 [KO:K05692]
101487996  actin, cytoplasmic 2-like [KO:K05692]
101485620  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101474865  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101482122  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101473117  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101475777  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101476411  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101479745  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101470495  cttn; src substrate cortactin isoform X1 [KO:K06106]
101481917  src substrate cortactin isoform X1 [KO:K06106]
101481337  actin-related protein 2-A [KO:K17260]
101465187  actr2; actin-related protein 2 [KO:K17260]
101476876  actin-related protein 3B isoform X1 [KO:K18584]
101467416  actin-related protein 3 [KO:K18584]
101475383  actin-related protein 3 [KO:K18584]
101468635  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101469153  actin-related protein 2/3 complex subunit 1B [KO:K05757]
101471957  actin-related protein 2/3 complex subunit 1A [KO:K05757]
101487555  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101476469  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101475148  actin-related protein 2/3 complex subunit 4 [KO:K05755]
101468546  actin-related protein 2/3 complex subunit 4 [KO:K05755]
101474410  actin-related protein 2/3 complex subunit 5 [KO:K05754]
101472838  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101485325  whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
101473005  was; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
101474454  vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101482847  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101482575  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101470440  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101473852  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101474166  rab13; ras-related protein Rab-13 [KO:K06109]
101480595  rho guanine nucleotide exchange factor 18 [KO:K21066]
101470286  arhgef18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
101478273  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101475967  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101470679  rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
101478915  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101482094  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101476073  epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
101464183  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101487955  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101471464  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101470867  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
101465686  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101471783  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101476687  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
101467149  5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
101480396  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
101485259  5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
101482213  5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
101471213  myosin-10 isoform X1 [KO:K10352]
101478531  myh9; myosin-9 isoform X1 [KO:K10352]
101487875  myh11; myosin-11 isoform X1 [KO:K10352]
101474159  myosin-10 isoform X1 [KO:K10352]
101475480  myosin-9 isoform X1 [KO:K10352]
101481329  myosin light polypeptide 6 [KO:K12751]
101480989  myosin light polypeptide 6 isoform X2 [KO:K12751]
101473299  myosin regulatory light polypeptide 9 [KO:K12755]
101476290  myosin regulatory light polypeptide 9 [KO:K12757]
101484951  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
101482193  immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
101482550  immunoglobulin superfamily member 5 [KO:K06786]
101479397  magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15 [KO:K05631]
101472309  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101476286  synpo; synaptopodin isoform X1 [KO:K21112]
101469024  alpha-actinin-1 isoform X3 [KO:K05699]
101467576  alpha-actinin-4 isoform X2 [KO:K05699]
101467781  micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
101479685  MICAL-like protein 2 isoform X1 [KO:K21068]
101474139  ras-related protein Rab-8A [KO:K07901]
101478042  rab8a; ras-related protein Rab-8A [KO:K07901]
101472377  ras-related protein Rab-8B [KO:K07902]
101478685  ras-related protein Rab-8B [KO:K07902]
101467019  rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
101466020  ras-related protein Rap-1A [KO:K04353]
101483640  ras-related protein Rap-1A [KO:K04353]
101466194  integrin beta-1 isoform X1 [KO:K05719]
101477882  afadin isoform X5 [KO:K05702]
101467084  afdn; LOW QUALITY PROTEIN: afadin [KO:K05702]
101484906  tjp2; tight junction protein ZO-2 isoform X1 [KO:K06098]
101469290  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
101470780  ras-related protein Rap-2c [KO:K07839]
101480447  MARVEL domain-containing protein 2 [KO:K17291]
101466532  MARVEL domain-containing protein 2 [KO:K17291]
101479010  MARVEL domain-containing protein 2 [KO:K17291]
101475061  tubulin alpha chain-like [KO:K07374]
101471801  tubulin alpha chain isoform X2 [KO:K07374]
101480465  tubulin alpha chain [KO:K07374]
101486701  tubulin alpha-1C chain [KO:K07374]
105941124  tubulin alpha-1C chain isoform X4 [KO:K07374]
101471595  tubulin alpha-1B chain [KO:K07374]
101484757  tubulin alpha-8 chain [KO:K07374]
106674879  tubulin alpha chain [KO:K07374]
106676044  tubulin alpha chain [KO:K07374]
101472165  tubulin alpha-1B chain [KO:K07374]
101475575  tubulin alpha chain isoform X1 [KO:K07374]
106674509  tubulin alpha-1D chain-like [KO:K07374]
112435909  tubulin alpha chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mze04520  Adherens junction
mze04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

DBGET integrated database retrieval system