KEGG   PATHWAY: osa04626
osa04626                    Pathway                                
Plant-pathogen interaction - Oryza sativa japonica (Japanese rice) (RefSeq)
Plants lack animal-like adaptive immunity mechanisms, and therefore have evolved a specific system with multiple layers against invading pathogens. The primary response includes the perception of pathogens by cell-surface pattern-recognition receptors (PRRs) and is referred to as PAMP-triggered immunity (PTI). Activation of FLS2 and EFR triggers MAPK signaling pathway that activates defense genes for antimictobial compounds. The increase in the cytosolic Ca2+ concentration is also a regulator for production of reactive oxygen species and localized programmed cell death/hypersensitive response. The secondary response is called effector-triggered immunity (ETI). Pathogens can acquire the ability to suppress PTI by directly injecting effector proteins into the plant cell through secretion systems. In addition, pathogens can manipulate plant hormone signaling pathways to evade host immune responses using coronatine toxin. Some plants possess specific intracellular surveillance proteins (R proteins) to monitor the presence of pathogen virulence proteins. This ETI occurs with localized programmed cell death to arrest pathogen growth, resulting in cultivar-specific disease resistance.
Organismal Systems; Environmental adaptation
Pathway map
osa04626  Plant-pathogen interaction

Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
4326638  calcium-dependent protein kinase 3 [KO:K13412] [EC:]
4349899  calcium-dependent protein kinase SK5 [KO:K13412] [EC:]
4333767  calcium-dependent protein kinase 10 [KO:K13412] [EC:]
4343373  calcium-dependent protein kinase isoform 2 [KO:K13412] [EC:]
4330351  calcium-dependent protein kinase 26 [KO:K13412] [EC:]
4343644  calcium-dependent protein kinase 8 [KO:K13412] [EC:]
4352234  calcium-dependent protein kinase 1 [KO:K13412] [EC:]
4339751  calcium-dependent protein kinase 3 [KO:K13412] [EC:]
4327560  calcium-dependent protein kinase 34 [KO:K13412] [EC:]
4328155  calcium-dependent protein kinase 16 isoform X1 [KO:K13412] [EC:]
4334519  calcium-dependent protein kinase 8 [KO:K13412] [EC:]
4346187  calcium-dependent protein kinase 13 [KO:K13412] [EC:]
4347564  calcium-dependent protein kinase 32 [KO:K13412] [EC:]
4351829  calcium-dependent protein kinase 7 [KO:K13412] [EC:]
4351620  calcium-dependent protein kinase 11 [KO:K13412] [EC:]
4331257  calcium-dependent protein kinase 26 [KO:K13412] [EC:]
4331490  calcium-dependent protein kinase isoform 11 [KO:K13412] [EC:]
4349249  calcium-dependent protein kinase isoform 1 [KO:K13412] [EC:]
4349714  calcium-dependent protein kinase 34 [KO:K13412] [EC:]
4343002  calcium-dependent protein kinase 28 [KO:K13412] [EC:]
4342456  calcium-dependent protein kinase 26 [KO:K13412] [EC:]
4334371  calcium-dependent protein kinase 26 [KO:K13412] [EC:]
4336783  calcium-dependent protein kinase 26 [KO:K13412] [EC:]
4336653  calcium-dependent protein kinase 2 [KO:K13412] [EC:]
9266580  calcium-dependent protein kinase 34 [KO:K13412] [EC:]
4339177  calcium-dependent protein kinase 34 [KO:K13412] [EC:]
107276318  calcium-dependent protein kinase 2-like [KO:K13412] [EC:]
4327438  calcium-dependent protein kinase 13 [KO:K13412] [EC:]
4343929  CDPK-related kinase 5 [KO:K13412] [EC:]
4344066  calcium/calmodulin-dependent serine/threonine-protein kinase 1-like [KO:K13412] [EC:]
4342059  CDPK-related kinase 3 [KO:K13412] [EC:]
4349091  CDPK-related kinase 3 [KO:K13412] [EC:]
4339397  respiratory burst oxidase homolog protein A [KO:K13447] [EC:1.6.3.- 1.11.1.-]
4326027  respiratory burst oxidase homolog protein B [KO:K13447] [EC:1.6.3.- 1.11.1.-]
4347158  respiratory burst oxidase homolog protein E [KO:K13447] [EC:1.6.3.- 1.11.1.-]
4345742  respiratory burst oxidase homolog protein E [KO:K13447] [EC:1.6.3.- 1.11.1.-]
4324163  respiratory burst oxidase homolog protein A [KO:K13447] [EC:1.6.3.- 1.11.1.-]
107278041  respiratory burst oxidase homolog protein B-like [KO:K13447] [EC:1.6.3.- 1.11.1.-]
4352439  respiratory burst oxidase homolog protein B [KO:K13447] [EC:1.6.3.- 1.11.1.-]
4334172  cyclic nucleotide-gated ion channel 2 [KO:K05391]
4339240  cyclic nucleotide-gated ion channel 4 [KO:K05391]
4351579  putative cyclic nucleotide-gated ion channel 18 [KO:K05391]
4341189  cyclic nucleotide-gated ion channel 1 isoform X1 [KO:K05391]
4330967  probable cyclic nucleotide-gated ion channel 17 [KO:K05391]
4333569  probable cyclic nucleotide-gated ion channel 6 [KO:K05391]
4330041  putative cyclic nucleotide-gated ion channel 15 [KO:K05391]
4330882  probable cyclic nucleotide-gated ion channel 20, chloroplastic [KO:K05391]
4347834  probable cyclic nucleotide-gated ion channel 17 [KO:K05391]
4328912  cyclic nucleotide-gated ion channel 1 [KO:K05391]
4337181  probable cyclic nucleotide-gated ion channel 6 [KO:K05391]
9270461  putative cyclic nucleotide-gated ion channel 7 [KO:K05391]
4340354  probable cyclic nucleotide-gated ion channel 17 [KO:K05391]
4340443  probable cyclic nucleotide-gated ion channel 20, chloroplastic [KO:K05391]
9268834  probable cyclic nucleotide-gated ion channel 17 isoform X1 [KO:K05391]
9271041  cyclic nucleotide-gated ion channel 4 [KO:K05391]
4326903  calmodulin-3 [KO:K02183]
4339172  calmodulin-2 [KO:K02183]
4324384  calmodulin [KO:K02183]
4334072  calmodulin-like protein 4 [KO:K02183]
4327351  calmodulin-like protein 1 [KO:K02183]
4332664  calmodulin [KO:K02183]
107276719  putative calmodulin-like protein 6 [KO:K02183]
4339171  probable calcium-binding protein CML9 [KO:K02183]
4349699  putative calmodulin-like protein 2 isoform X1 [KO:K02183]
4351420  calmodulin-like protein 3 isoform X1 [KO:K02183]
4325488  probable calcium-binding protein CML41 [KO:K13448]
4325762  probable calcium-binding protein CML10 [KO:K13448]
4349736  probable calcium-binding protein CML49 [KO:K13448]
4324037  probable calcium-binding protein CML11 [KO:K13448]
4343922  probable calcium-binding protein CML13 [KO:K13448]
4328628  probable calcium-binding protein CML21 isoform X1 [KO:K13448]
4325408  probable calcium-binding protein CML31 [KO:K13448]
4351825  probable calcium-binding protein CML28 [KO:K13448]
4346325  polcalcin Phl p 7 [KO:K13448]
4339701  probable calcium-binding protein CML14 [KO:K13448]
4344651  probable calcium-binding protein CML32 [KO:K13448]
4344525  probable calcium-binding protein CML7 [KO:K13448]
4336258  probable calcium-binding protein CML22 [KO:K13448]
4344304  probable calcium-binding protein CML24 [KO:K13448]
4351450  probable calcium-binding protein CML49 [KO:K13448]
4334250  probable calcium-binding protein CML41 [KO:K13448]
4325760  probable calcium-binding protein CML10 [KO:K13448]
4349547  probable calcium-binding protein CML25/26 [KO:K13448]
4341500  probable calcium-binding protein CML21 [KO:K13448]
4324100  probable calcium-binding protein CML12 [KO:K13448]
4325693  probable calcium-binding protein CML16 [KO:K13448]
4338633  probable calcium-binding protein CML15 [KO:K13448]
4346304  probable calcium-binding protein CML48 [KO:K13448]
4332731  probable calcium-binding protein CML27 [KO:K13448]
4347274  calmodulin-like protein 1 [KO:K13448]
4351256  probable calcium-binding protein CML25/26 [KO:K13448]
107276351  probable calcium-binding protein CML22 isoform X1 [KO:K13448]
107277351  putative calcium-binding protein CML19 [KO:K13448]
107277511  putative calcium-binding protein CML23 [KO:K13448]
4349740  probable calcium-binding protein CML36 [KO:K13448]
4351455  probable calcium-binding protein CML36 [KO:K13448]
9266860  probable calcium-binding protein CML18 [KO:K13448]
4338382  probable calcium-binding protein CML21 [KO:K13448]
4348517  probable calcium-binding protein CML8 [KO:K13448]
4352729  calmodulin-like protein 5 [KO:K13448]
9272185  probable calcium-binding protein CML17 [KO:K13448]
4328006  putative nitric oxide synthase [KO:K13427] [EC:]
4344698  mitogen-activated protein kinase 2 [KO:K20600] [EC:]
4337016  LRR receptor-like serine/threonine-protein kinase FLS2 [KO:K13420] [EC:]
4334800  elongation factor Tu, mitochondrial [KO:K02358]
9270837  elongation factor Tu, chloroplastic [KO:K02358]
4332325  mitogen-activated protein kinase kinase kinase 1 [KO:K13414] [EC:]
4333845  mitogen-activated protein kinase kinase kinase 1 [KO:K13414] [EC:]
4324023  mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:]
4330957  mitogen-activated protein kinase kinase 5 [KO:K13413] [EC:]
4340367  mitogen-activated protein kinase kinase 5 [KO:K13413] [EC:]
4340368  mitogen-activated protein kinase kinase 5 [KO:K13413] [EC:]
4332475  mitogen-activated protein kinase 5 isoform X2 [KO:K20536] [EC:]
4340170  mitogen-activated protein kinase 1 [KO:K14512] [EC:]
4327518  probable WRKY transcription factor 33 [KO:K13424]
4338474  probable WRKY transcription factor 26 isoform X1 [KO:K13424]
4339092  probable WRKY transcription factor 33 [KO:K13424]
4326683  WRKY transcription factor 22 [KO:K13425]
9267508  WRKY transcription factor 22 [KO:K13425]
4337206  glycerol kinase [KO:K00864] [EC:]
4342314  pathogenesis-related protein PRB1-3 [KO:K13449]
4325422  pathogenesis-related protein 1 [KO:K13449]
4342317  pathogenesis-related protein PRB1-3 [KO:K13449]
4348237  pathogenesis-related protein PRB1-2 [KO:K13449]
107278128  pathogenesis-related protein PRB1-3-like [KO:K13449]
107278129  pathogenesis-related protein PRB1-3-like [KO:K13449]
107277171  pathogenesis-related protein PRB1-2-like [KO:K13449]
4325424  pathogenesis-related protein PRB1-2 [KO:K13449]
4342318  pathogenesis-related protein 1 [KO:K13449]
107275384  pathogenesis-related protein PRB1-3-like [KO:K13449]
107275413  pathogenesis-related protein 1-like [KO:K13449]
107275753  pathogenesis-related protein 1A-like [KO:K13449]
107276458  pathogenesis-related protein PRB1-3-like [KO:K13449]
107276764  pathogenesis-related protein PRB1-3-like [KO:K13449]
107277316  pathogenesis-related protein 1-like [KO:K13449]
107281807  pathogenesis-related protein PRMS-like [KO:K13449]
4342310  pathogenesis-related protein 1 [KO:K13449]
9270927  pathogenesis-related protein 1 [KO:K13449]
107277170  pathogenesis-related protein PRB1-2-like [KO:K13449]
9268689  pathogenesis-related protein PRB1-2 [KO:K13449]
4342316  pathogenesis-related protein PRB1-2 [KO:K13449]
4342311  pathogenesis-related protein PRB1-3 [KO:K13449]
4342313  pathogenesis-related protein PRB1-2 [KO:K13449]
4342315  pathogenesis-related protein PRB1-2 [KO:K13449]
4337734  pto-interacting protein 1 [KO:K13436] [EC:]
4325029  PTI1-like tyrosine-protein kinase 1 [KO:K13436] [EC:]
4334756  PTI1-like tyrosine-protein kinase 1 [KO:K13436] [EC:]
4347559  PTI1-like tyrosine-protein kinase 3 isoform X1 [KO:K13436] [EC:]
4326993  pto-interacting protein 1 [KO:K13436] [EC:]
4336242  PTI1-like tyrosine-protein kinase 3 [KO:K13436] [EC:]
4346097  RPM1-interacting protein 4 isoform X1 [KO:K13456]
4334782  RPM1-interacting protein 4 [KO:K13456]
4335624  RPM1-interacting protein 4 [KO:K13456]
9268959  RPM1-interacting protein 4 [KO:K13456]
4342596  disease resistance protein RPM1 [KO:K13457]
4326180  disease resistance protein RPM1 isoform X1 [KO:K13457]
4352270  disease resistance protein RPM1 [KO:K13457]
4348062  disease resistance protein RPM1 [KO:K13457]
4347381  disease resistance protein RPM1 [KO:K13457]
4350733  disease resistance protein RPM1 [KO:K13457]
4351886  disease resistance protein RPM1 [KO:K13457]
107276258  disease resistance protein RPM1-like [KO:K13457]
107277214  disease resistance protein RPM1-like isoform X1 [KO:K13457]
4336576  disease resistance protein RPM1 isoform X1 [KO:K13457]
4340191  disease resistance protein RPM1 [KO:K13457]
4345108  disease resistance protein RPM1 isoform X1 [KO:K13457]
9267892  disease resistance protein RPM1 [KO:K13457]
9268330  disease resistance protein RPM1 isoform X1 [KO:K13457]
4350121  disease resistance protein RPM1 isoform X1 [KO:K13457]
4323952  disease resistance protein RPM1 [KO:K13457]
107276215  disease resistance protein RPM1-like [KO:K13457]
4347382  disease resistance protein RPM1 isoform X1 [KO:K13457]
4329567  cysteine and histidine-rich domain-containing protein RAR1 [KO:K13458]
4326682  protein SGT1 homolog [KO:K12795]
4342077  endoplasmin homolog [KO:K09487]
4345893  heat shock protein 90-5, chloroplastic [KO:K09487]
4352339  heat shock protein 90-6, mitochondrial [KO:K09487]
4347356  heat shock protein 90-5, chloroplastic [KO:K09487]
4347402  heat shock protein 81-2 [KO:K04079]
4345951  heat shock protein 81-1 [KO:K04079]
4347405  heat shock protein 81-3 isoform X1 [KO:K04079]
9267802  heat shock protein 81-3 [KO:K04079]
9267997  heat shock protein 82 [KO:K04079]
4325862  disease resistance protein RPS2 [KO:K13459]
4336120  probable disease resistance protein At4g14610 [KO:K13459]
4329463  serine/threonine-protein kinase PBS1 [KO:K13430] [EC:]
4335687  serine/threonine-protein kinase CDL1 isoform X1 [KO:K13430] [EC:]
4346962  protein EDS1L [KO:K18875]
4329339  cysteine proteinase 1 [KO:K01373] [EC:]
4335455  cysteine proteinase 1 [KO:K01373] [EC:]
4343231  probable cysteine proteinase A494 [KO:K01373] [EC:]
4341445  3-ketoacyl-CoA synthase 11 [KO:K15397] [EC:]
4328676  3-ketoacyl-CoA synthase 11 isoform X1 [KO:K15397] [EC:]
4330627  3-ketoacyl-CoA synthase 6 [KO:K15397] [EC:]
4331836  3-ketoacyl-CoA synthase 10 [KO:K15397] [EC:]
4332090  3-ketoacyl-CoA synthase 6 [KO:K15397] [EC:]
4332236  3-ketoacyl-CoA synthase 1 [KO:K15397] [EC:]
4339645  3-ketoacyl-CoA synthase 4 [KO:K15397] [EC:]
4339684  3-ketoacyl-CoA synthase 11 [KO:K15397] [EC:]
4340691  3-ketoacyl-CoA synthase 6 [KO:K15397] [EC:]
4340693  3-ketoacyl-CoA synthase 6 [KO:K15397] [EC:]
4340694  3-ketoacyl-CoA synthase 5 [KO:K15397] [EC:]
4348145  3-ketoacyl-CoA synthase 1 [KO:K15397] [EC:]
4350817  3-ketoacyl-CoA synthase 20 [KO:K15397] [EC:]
4332981  3-ketoacyl-CoA synthase 12 [KO:K15397] [EC:]
4331714  3-ketoacyl-CoA synthase 11 [KO:K15397] [EC:]
4348632  3-ketoacyl-CoA synthase 20 [KO:K15397] [EC:]
4348874  3-ketoacyl-CoA synthase 12 [KO:K15397] [EC:]
4331113  3-ketoacyl-CoA synthase 12 [KO:K15397] [EC:]
4332986  3-ketoacyl-CoA synthase 19 [KO:K15397] [EC:]
4340695  3-ketoacyl-CoA synthase 5 [KO:K15397] [EC:]
4346846  3-ketoacyl-CoA synthase 17 [KO:K15397] [EC:]
9269580  3-ketoacyl-CoA synthase 19 [KO:K15397] [EC:]
9271565  3-ketoacyl-CoA synthase 4 [KO:K15397] [EC:]
9272344  LOW QUALITY PROTEIN: 3-ketoacyl-CoA synthase 6 [KO:K15397] [EC:]
4323946  3-ketoacyl-CoA synthase 5 [KO:K15397] [EC:]
4345940  probable WRKY transcription factor 2 [KO:K18835]
4336126  probable WRKY transcription factor 2 isoform X1 [KO:K18835]
4347399  probable WRKY transcription factor 2 [KO:K18835]
107276510  probable LRR receptor-like serine/threonine-protein kinase At3g47570 [KO:K13437]
4331523  chitin elicitor-binding protein [KO:K13473]
4346173  chitin elicitor receptor kinase 1-like isoform X2 [KO:K13429]
9270778  chitin elicitor receptor kinase 1 isoform X2 [KO:K13429]
C00027  Hydrogen peroxide
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C16844  Hydroxyl radical
Zipfel C
Pattern-recognition receptors in plant innate immunity.
Curr Opin Immunol 20:10-6 (2008)
Chinchilla D, Shan L, He P, de Vries S, Kemmerling B
One for all: the receptor-associated kinase BAK1.
Trends Plant Sci 14:535-41 (2009)
Boller T, He SY
Innate immunity in plants: an arms race between pattern recognition receptors in plants and effectors in microbial pathogens.
Science 324:742-4 (2009)
Ma W, Smigel A, Verma R, Berkowitz GA
Cyclic nucleotide gated channels and related signaling components in plant innate immunity.
Plant Signal Behav 4:277-82 (2009)
Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
MAP kinase signalling cascade in Arabidopsis innate immunity.
Nature 415:977-83 (2002)
Zipfel C, Felix G
Plants and animals: a different taste for microbes?
Curr Opin Plant Biol 8:353-60 (2005)
He P, Shan L, Sheen J
Elicitation and suppression of microbe-associated molecular pattern-triggered immunity in plant-microbe interactions.
Cell Microbiol 9:1385-96 (2007)
de Wit PJ
How plants recognize pathogens and defend themselves.
Cell Mol Life Sci 64:2726-32 (2007)
Chisholm ST, Coaker G, Day B, Staskawicz BJ
Host-microbe interactions: shaping the evolution of the plant immune response.
Cell 124:803-14 (2006)
McHale L, Tan X, Koehl P, Michelmore RW
Plant NBS-LRR proteins: adaptable guards.
Genome Biol 7:212 (2006)
Dangl JL, Jones JD
Plant pathogens and integrated defence responses to infection.
Nature 411:826-33 (2001)
Jones JD, Dangl JL
The plant immune system.
Nature 444:323-9 (2006)
da Cunha L, McFall AJ, Mackey D
Innate immunity in plants: a continuum of layered defenses.
Microbes Infect 8:1372-81 (2006)
Mudgett MB
New insights to the function of phytopathogenic bacterial type III effectors in plants.
Annu Rev Plant Biol 56:509-31 (2005)
Ma W, Berkowitz GA
The grateful dead: calcium and cell death in plant innate immunity.
Cell Microbiol 9:2571-85 (2007)
Schulze-Lefert P
Plant immunity: the origami of receptor activation.
Curr Biol 14:R22-4 (2004)
Van der Biezen EA, Jones JD
Plant disease-resistance proteins and the gene-for-gene concept.
Trends Biochem Sci 23:454-6 (1998)
Abramovitch RB, Anderson JC, Martin GB
Bacterial elicitation and evasion of plant innate immunity.
Nat Rev Mol Cell Biol 7:601-11 (2006)
osa04144  Endocytosis
KO pathway

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