KEGG   PATHWAY: aang04914
Entry
aang04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Anguilla anguilla (European eel)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
aang04914  Progesterone-mediated oocyte maturation
aang04914

Other DBs
GO: 0001556
Organism
Anguilla anguilla (European eel) [GN:aang]
Gene
118209581  pgr; progesterone receptor isoform X1 [KO:K08556]
118235591  progesterone receptor-like [KO:K08556]
118228853  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
118206252  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
118225456  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118212644  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118225588  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118209617  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118229817  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118223556  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118211053  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118225726  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
118236139  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
118223663  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118217861  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118212863  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118220848  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118211184  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118219295  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
118219296  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
118207330  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
118208135  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118208667  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118210995  gnai2a; guanine nucleotide-binding protein G(i) subunit alpha-2a [KO:K04630]
118211133  guanine nucleotide-binding protein G(i) subunit alpha-like [KO:K04630]
118219298  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118232483  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
118207763  gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
118208074  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118224561  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
118233055  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
118225550  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
118234313  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
118228793  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
118207103  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118223221  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
118208186  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
118227441  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
118215074  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118229366  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118234492  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118217014  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
118219851  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
118228903  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
118216144  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
118226503  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118221335  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118208549  aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
118236310  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
118215706  cpeb1a; cytoplasmic polyadenylation element-binding protein 1a isoform X1 [KO:K02602]
118223352  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
118217914  cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
118225939  cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
118223781  spdya; speedy protein A [KO:K08694]
118223482  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
118210582  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
118218252  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118235256  ccna1; cyclin-A1 [KO:K06627]
118231092  ccna2; cyclin-A2 [KO:K06627]
118225048  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
118229338  heat shock protein HSP 90-alpha [KO:K04079]
118229339  heat shock protein HSP 90-alpha 1-like [KO:K04079]
118230802  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
118213512  heat shock protein HSP 90-alpha [KO:K04079]
118220277  heat shock protein HSP 90-alpha 1 [KO:K04079]
118214767  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118216741  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118206414  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118220249  mitogen-activated protein kinase 1-like isoform X1 [KO:K04371] [EC:2.7.11.24]
118236409  ribosomal protein S6 kinase alpha-6-like isoform X1 [KO:K04373] [EC:2.7.11.1]
118235568  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118223699  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
118217558  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118228146  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118220227  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
118212233  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
118226951  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
118234945  stk10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
118220062  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
118227409  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
118222606  M-phase inducer phosphatase 1-B-like [KO:K05867] [EC:3.1.3.48]
118235395  insulin-like [KO:K04526]
118235396  insulin-like [KO:K04526]
118235397  insulin-like [KO:K04526]
118216348  insulin [KO:K04526]
118219087  insulin-like growth factor I, adult form isoform X1 [KO:K05459]
118232412  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
118215508  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118227904  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118235210  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118209642  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118229023  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118217744  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118221018  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118236468  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118227005  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like isoform X1 [KO:K13296] [EC:3.1.4.17]
118215024  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like isoform X1 [KO:K13296] [EC:3.1.4.17]
118216525  zgc:55558; GTPase HRas [KO:K07827]
118218999  GTPase KRas isoform X1 [KO:K07827]
118208073  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
118232005  serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
118219026  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118210668  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118218322  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
118220822  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
118232043  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
118207577  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
118230609  fizzy-related protein homolog isoform X1 [KO:K03364]
118225260  fzr1b; fizzy-related protein homolog isoform X1 [KO:K03364]
118226182  fzr1a; fizzy/cell division cycle 20 related 1a isoform X1 [KO:K03364]
118218226  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
118212880  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
118216500  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
118221316  cell division cycle protein 27 homolog [KO:K03350]
118225943  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
118207065  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
118213946  cdc16; cell division cycle protein 16 homolog [KO:K03353]
118206729  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
118236282  cdc23; cell division cycle protein 23 homolog [KO:K03355]
118231572  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
118219669  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
118212530  cdc26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
118235412  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
118210394  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
118221545  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
118220224  kif22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
aang04010  MAPK signaling pathway
aang04110  Cell cycle
KO pathway
ko04914   
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