KEGG   PATHWAY: aang04110
Entry
aang04110                   Pathway                                
Name
Cell cycle - Anguilla anguilla (European eel)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
aang04110  Cell cycle
aang04110

Other DBs
GO: 0000278
Organism
Anguilla anguilla (European eel) [GN:aang]
Gene
118206292  ccnh; cyclin-H [KO:K06634]
118206371  [KO:K04402]
118206372  gadd45ga; growth arrest and DNA-damage-inducible, gamma a isoform X1 [KO:K04402]
118206373  [KO:K04402]
118206406  [KO:K04382] [EC:3.1.3.16]
118206576  smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
118206601  [KO:K06619] [EC:2.7.10.2]
118206729  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
118206841  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
118207065  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
118207213  e2f1; transcription factor E2F1 [KO:K17454]
118207288  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
118207309  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
118207577  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
118207774  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
118208153  [KO:K16197]
118208887  [KO:K16197]
118208918  pds5b; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
118209125  dbf4; protein DBF4 homolog A [KO:K06629]
118209403  [KO:K13375]
118209591  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
118209838  [KO:K03456]
118209935  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
118209968  tfdp2; transcription factor Dp-2 isoform X1 [KO:K09392]
118210057  [KO:K16198]
118210103  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
118210344  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
118210394  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
118210582  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
118210620  cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
118210628  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
118210800  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
118210840  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118210980  rbl1; retinoblastoma-like protein 1 [KO:K04681]
118211236  mtbp; mdm2-binding protein [KO:K26116]
118211359  espl1; separin [KO:K02365] [EC:3.4.22.49]
118211911  rad21l1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
118211941  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
118212126  [KO:K04402]
118212127  [KO:K04402]
118212128  [KO:K04402]
118212179  [KO:K04802]
118212193  [KO:K06620]
118212233  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
118212239  skp2; S-phase kinase-associated protein 2 [KO:K03875]
118212530  cdc26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
118212532  [KO:K16198]
118212702  [KO:K04501]
118212827  [KO:K06619] [EC:2.7.10.2]
118212880  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
118213062  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118213713  tfdp1b; transcription factor Dp-1b isoform X1 [KO:K04683]
118213946  cdc16; cell division cycle protein 16 homolog [KO:K03353]
118214206  [KO:K06067] [EC:3.5.1.98]
118214338  [KO:K03083] [EC:2.7.11.26]
118214848  [KO:K06632] [EC:2.7.11.1]
118214864  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
118214878  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
118215511  [KO:K04503]
118215781  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
118215823  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
118216349  [KO:K06623]
118216500  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
118216655  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
118216689  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
118216758  [KO:K02180]
118216889  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118217013  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
118217069  cdk21; cyclin-dependent kinase 4 isoform X1 [KO:K02091] [EC:2.7.11.22]
118217070  [KO:K02091] [EC:2.7.11.22]
118217071  [KO:K02091] [EC:2.7.11.22]
118217739  fbxo5; F-box only protein 5 isoform X1 [KO:K10292]
118217959  mad2l1bp; MAD2L1-binding protein [KO:K26093]
118218024  wapla; wings apart-like protein homolog [KO:K25163]
118218128  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
118218226  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
118218252  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118218322  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
118218424  dbf4b; serine/arginine repetitive matrix protein 1 [KO:K06629]
118218489  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
118218494  [KO:K02180]
118218515  [KO:K03868] [EC:2.3.2.32]
118218857  ttk; dual specificity protein kinase Ttk [KO:K08866] [EC:2.7.12.1]
118219035  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118219073  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
118219144  [KO:K06624]
118219669  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
118219849  [KO:K04498] [EC:2.3.1.48]
118220062  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
118220227  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
118220632  waplb; wings apart-like protein homolog [KO:K25163]
118220634  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118220822  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
118220933  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118221316  [KO:K03350]
118221545  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
118221805  cdc6; cell division control protein 6 homolog [KO:K02213]
118222214  [KO:K06671]
118222354  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
118222376  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
118222454  ppp2r5eb; LOW QUALITY PROTEIN: protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
118222606  [KO:K05867] [EC:3.1.3.48]
118222676  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
118222905  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118223000  [KO:K04451]
118223047  [KO:K04382] [EC:3.1.3.16]
118223049  [KO:K03094]
118223062  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
118223277  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
118223324  pttg1; securin isoform X1 [KO:K06635]
118223366  cdca5; sororin [KO:K17390]
118223482  [KO:K02206] [EC:2.7.11.22]
118223507  e2f2; transcription factor E2F2 [KO:K09389]
118223536  orc4; origin recognition complex subunit 4 [KO:K02606]
118223883  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
118223891  [KO:K16197]
118223898  si:ch211-269e2.1; cohesin subunit SA-1 [KO:K06671]
118224101  stag2b; cohesin subunit SA-2 [KO:K06671]
118224248  orc2; origin recognition complex subunit 2 [KO:K02604]
118224366  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
118224511  [KO:K04377]
118224549  [KO:K04402]
118224555  [KO:K11266]
118224762  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
118224763  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
118224776  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
118224982  [KO:K06671]
118225180  [KO:K03347]
118225260  fzr1b; fizzy-related protein homolog isoform X1 [KO:K03364]
118225528  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
118225705  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like [KO:K02541] [EC:5.6.2.3]
118225943  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
118226123  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
118226182  fzr1a; fizzy/cell division cycle 20 related 1a isoform X1 [KO:K03364]
118226847  e2f4; transcription factor E2F4 [KO:K04682]
118226896  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
118226917  [KO:K06632] [EC:2.7.11.1]
118226951  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
118227409  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
118227421  orc6; origin recognition complex subunit 6 [KO:K02608]
118227538  cdt1; DNA replication factor Cdt1 [KO:K10727]
118227787  pds5a; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
118228065  ticrr; treslin isoform X1 [KO:K26117]
118228076  [KO:K04503]
118228826  esco2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
118228876  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
118228941  [KO:K04402]
118228983  [KO:K13377]
118229063  [KO:K11266]
118229069  [KO:K13376]
118229095  cdc20; cell division cycle protein 20 homolog [KO:K03363]
118229101  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
118229337  [KO:K11584]
118229512  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
118229690  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
118229835  mcm3; DNA replication licensing factor MCM3 isoform X1 [KO:K02541] [EC:5.6.2.3]
118230011  ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a [KO:K16197]
118230321  knl1; uncharacterized protein knl1 isoform X1 [KO:K11542]
118230329  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
118230424  [KO:K11584]
118230466  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
118230609  [KO:K03364]
118230782  [KO:K06067] [EC:3.5.1.98]
118230889  [KO:K06671]
118231092  ccna2; cyclin-A2 [KO:K06627]
118231211  smc1b; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
118231572  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
118231828  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
118232043  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
118232052  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
118232094  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
118232208  [KO:K11267]
118232306  [KO:K06624]
118232368  orc5; origin recognition complex subunit 5 [KO:K02607]
118232878  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
118232993  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
118233022  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
118233044  [KO:K03347]
118233125  sgo1; shugoshin 1 isoform X1 [KO:K11580]
118233348  [KO:K06067] [EC:3.5.1.98]
118233471  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118234075  rad21b; RAD21 cohesin complex component b [KO:K06670]
118234505  [KO:K16197]
118234530  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
118234607  e2f3; transcription factor E2F3 [KO:K06620]
118234630  e2f5; transcription factor E2F5 [KO:K04682]
118234756  [KO:K04377]
118234955  skp1; S-phase kinase-associated protein 1 [KO:K03094]
118235087  rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118235244  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
118235256  ccna1; cyclin-A1 [KO:K06627]
118235259  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
118235412  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
118235685  [KO:K10779]
118235846  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118235917  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
118236280  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
118236282  cdc23; cell division cycle protein 23 homolog [KO:K03355]
118236400  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118236609  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
118236671  [KO:K06670]
118236698  si:dkey-239n17.4; mothers against decapentaplegic homolog 4 [KO:K04501]
118236725  [KO:K11584]
118236763  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
118237231  [KO:K04802]
118237332  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
118237474  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
118237503  nipbla; nipped-B-like protein A isoform X1 [KO:K06672]
118237524  cdc45; cell division control protein 45 homolog [KO:K06628]
118237532  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
aang03030  DNA replication
aang04010  MAPK signaling pathway
aang04120  Ubiquitin mediated proteolysis
aang04210  Apoptosis
KO pathway
ko04110   

DBGET integrated database retrieval system