KEGG   PATHWAY: aang04010
Entry
aang04010                   Pathway                                
Name
MAPK signaling pathway - Anguilla anguilla (European eel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
aang04010  MAPK signaling pathway
aang04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Anguilla anguilla (European eel) [GN:aang]
Gene
118206189  efna1b; ephrin-A1b [KO:K05462]
118206205  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
118206207  [KO:K03173] [EC:2.3.2.27]
118206291  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
118206299  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
118206305  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
118206360  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
118206371  [KO:K04402]
118206372  gadd45ga; growth arrest and DNA-damage-inducible, gamma a isoform X1 [KO:K04402]
118206373  [KO:K04402]
118206414  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118206426  si:dkey-1k23.3; heat shock protein 67B1 [KO:K04455]
118206434  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118206481  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
118206636  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
118206649  [KO:K04416] [EC:2.7.11.25]
118206655  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
118206745  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
118206754  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118206818  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118206829  fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
118206845  [KO:K05452]
118206919  efna5b; ephrin-A5b isoform X1 [KO:K05462]
118207102  [KO:K04519]
118207140  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
118207210  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
118207304  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
118207330  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
118207365  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
118207385  [KO:K05084] [EC:2.7.10.1]
118207697  [KO:K04444] [EC:2.7.11.1]
118207705  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
118207922  [KO:K04443] [EC:2.7.11.1]
118208073  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
118208113  [KO:K04851]
118208135  [KO:K04441] [EC:2.7.11.24]
118208143  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
118208156  [KO:K04350]
118208187  elk1; ETS domain-containing protein Elk-3 isoform X1 [KO:K04375]
118208260  nras; GTPase NRas [KO:K07828]
118208351  [KO:K04393]
118208353  [KO:K05453]
118208373  [KO:K04437]
118208386  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
118208465  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118208521  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
118208530  [KO:K04376]
118208607  ngfa; neurotrophin-7 [KO:K02582]
118208633  [KO:K18019] [EC:3.1.3.48]
118208634  [KO:K04857]
118208638  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118208640  [KO:K04427] [EC:2.7.11.25]
118208663  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
118208667  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118208937  [KO:K04350]
118208951  [KO:K03283]
118209005  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
118209088  relb; transcription factor RelB isoform X1 [KO:K09253]
118209118  map3k9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
118209323  [KO:K04455]
118209387  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
118209403  [KO:K13375]
118209642  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118209705  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
118209920  pdgfd; platelet-derived growth factor D [KO:K05450]
118209957  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
118210001  rasa2; ras GTPase-activating protein 2 [KO:K08053]
118210114  [KO:K04439]
118210208  [KO:K04723]
118210281  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118210344  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
118210521  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
118210531  [KO:K05103] [EC:2.7.10.1]
118210591  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
118210597  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118210606  [KO:K04853]
118210668  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118210904  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118210923  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
118211116  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
118211159  [KO:K03283]
118211160  [KO:K03283]
118211184  [KO:K04441] [EC:2.7.11.24]
118211196  [KO:K04864]
118211309  [KO:K04851]
118211420  [KO:K04411]
118211443  [KO:K04353]
118211615  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
118211653  [KO:K02582]
118211658  [KO:K04860]
118211664  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
118211767  [KO:K04437]
118211770  [KO:K04465]
118211802  [KO:K05084] [EC:2.7.10.1]
118211814  [KO:K04859]
118211887  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118211982  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
118211992  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
118212126  [KO:K04402]
118212127  [KO:K04402]
118212128  [KO:K04402]
118212137  [KO:K12326]
118212138  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
118212214  [KO:K04360] [EC:2.7.10.1]
118212259  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118212376  fgf10a; fibroblast growth factor 10a [KO:K04358]
118212394  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
118212525  il1b; interleukin-1 beta isoform X1 [KO:K04519]
118212554  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
118212690  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
118212703  [KO:K04455]
118212807  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
118212863  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118212899  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
118212930  [KO:K04438]
118212933  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118212982  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118213211  [KO:K03173] [EC:2.3.2.27]
118213247  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
118213253  [KO:K04358]
118213285  [KO:K05462]
118213699  [KO:K04422] [EC:2.7.11.25]
118214016  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
118214156  [KO:K04865]
118214264  [KO:K04450]
118214305  [KO:K04407] [EC:2.7.11.1]
118214486  [KO:K05449]
118214501  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118214654  [KO:K05085] [EC:2.7.10.1]
118214688  fgf19; fibroblast growth factor 19 [KO:K22603]
118214690  [KO:K04358]
118214767  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118214803  [KO:K05462]
118215059  [KO:K04434]
118215226  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118215237  [KO:K18018] [EC:3.1.3.48]
118215239  [KO:K13769]
118215285  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
118215287  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118215331  stmn1b; stathmin 1b [KO:K04381]
118215356  [KO:K02833]
118215423  [KO:K07830]
118215463  [KO:K04358]
118215508  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118215697  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
118215928  [KO:K22429]
118215961  [KO:K04867]
118215995  [KO:K04347]
118216047  [KO:K07861]
118216098  [KO:K04392]
118216144  [KO:K04345] [EC:2.7.11.11]
118216184  [KO:K04868]
118216348  [KO:K04526]
118216383  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118216405  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
118216411  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
118216497  maptb; microtubule-associated protein tau [KO:K04380]
118216525  zgc:55558; GTPase HRas [KO:K07827]
118216561  [KO:K04344]
118216698  [KO:K04855]
118216704  [KO:K19662] [EC:2.7.11.13]
118216741  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118216771  [KO:K04466] [EC:2.7.11.25]
118216775  [KO:K04862]
118216816  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
118216848  [KO:K04364]
118216885  [KO:K04430] [EC:2.7.12.2]
118216908  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118216977  [KO:K04856]
118217041  [KO:K04856]
118217046  [KO:K04432] [EC:2.7.12.2]
118217112  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118217257  atf4b; activating transcription factor 4b isoform X1 [KO:K04374]
118217270  [KO:K02583]
118217277  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
118217335  rras; ras-related protein R-Ras [KO:K07830]
118217348  [KO:K04436]
118217556  [KO:K04379]
118217558  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118217618  [KO:K04379]
118217694  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118217697  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
118217744  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118217861  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118217895  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
118217902  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
118217945  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
118217968  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
118217979  [KO:K04406] [EC:2.7.11.1]
118217986  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118218027  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118218059  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118218140  [KO:K04378]
118218207  [KO:K04855]
118218213  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
118218440  angpt2a; angiopoietin-2a [KO:K05466]
118218708  [KO:K05461]
118218837  [KO:K07836]
118218999  [KO:K07827]
118219026  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118219045  [KO:K04358]
118219087  [KO:K05459]
118219151  [KO:K04435]
118219163  [KO:K05099] [EC:2.7.10.1]
118219186  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
118219216  [KO:K04356]
118219259  [KO:K04858]
118219269  [KO:K05460]
118219282  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118219295  [KO:K04441] [EC:2.7.11.24]
118219296  [KO:K04441] [EC:2.7.11.24]
118219395  [KO:K22428]
118219396  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118219495  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118219598  [KO:K02677] [EC:2.7.11.13]
118219633  [KO:K04869]
118219639  [KO:K04870]
118219642  [KO:K04866]
118219706  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
118219764  [KO:K04868]
118219868  [KO:K04359]
118219958  pgfb; snake venom vascular endothelial growth factor toxin ICPP isoform X1 [KO:K16859]
118220060  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118220191  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118220207  [KO:K04429] [EC:2.7.11.1]
118220211  mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
118220249  [KO:K04371] [EC:2.7.11.24]
118220309  [KO:K19662] [EC:2.7.11.13]
118220320  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
118220322  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118220393  [KO:K25416]
118220545  [KO:K04364]
118220603  [KO:K04461] [EC:3.1.3.16]
118220615  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
118220672  [KO:K03099]
118220736  [KO:K04392]
118220757  [KO:K07861]
118220805  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118220848  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118220927  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
118221015  [KO:K04436]
118221018  [KO:K04456] [EC:2.7.11.1]
118221019  [KO:K04432] [EC:2.7.12.2]
118221076  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
118221088  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118221240  [KO:K04469]
118221254  [KO:K04346]
118221282  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
118221335  [KO:K04345] [EC:2.7.11.11]
118221412  [KO:K05465]
118221513  [KO:K04466] [EC:2.7.11.25]
118221559  [KO:K22429]
118221569  [KO:K04862]
118221586  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
118221665  fgf8b; fibroblast growth factor 8b [KO:K04358]
118221756  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118221801  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118221921  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
118221930  [KO:K02583]
118221944  [KO:K04378]
118222173  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
118222208  [KO:K05095] [EC:2.7.10.1]
118222218  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
118222562  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
118222643  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
118222676  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
118222765  fgf16; fibroblast growth factor 16 [KO:K04358]
118222942  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118222989  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
118223000  [KO:K04451]
118223006  cacng6b; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
118223052  arrb2b; arrestin, beta 2b isoform X1 [KO:K04439]
118223070  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
118223071  [KO:K05449]
118223115  vegfd; vascular endothelial growth factor D [KO:K05449]
118223116  [KO:K04407] [EC:2.7.11.1]
118223170  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118223172  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118223252  [KO:K05085] [EC:2.7.10.1]
118223296  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
118223372  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118223522  rela; transcription factor p65 [KO:K04735]
118223561  rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
118223663  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118223699  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
118223719  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
118223872  [KO:K04422] [EC:2.7.11.25]
118223901  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
118224160  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118224188  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
118224319  [KO:K04419] [EC:2.7.11.25]
118224341  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
118224367  [KO:K12361]
118224389  [KO:K04348] [EC:3.1.3.16]
118224403  [KO:K04386]
118224511  [KO:K04377]
118224549  [KO:K04402]
118224635  [KO:K04449]
118224640  efna2a; ephrin-A2 isoform X1 [KO:K05462]
118224705  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118224758  mknk2b; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
118224763  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
118224955  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118225096  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118225119  [KO:K25415]
118225219  [KO:K25414]
118225251  [KO:K04361] [EC:2.7.10.1]
118225399  map3k22; mitogen-activated protein kinase kinase kinase 22 isoform X1 [KO:K04421] [EC:2.7.11.25]
118225407  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118225408  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
118225515  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
118225723  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118225724  kita; mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
118225803  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
118225862  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
118225864  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
118225873  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
118226064  [KO:K04852]
118226069  [KO:K04674] [EC:2.7.11.30]
118226080  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
118226123  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
118226171  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118226179  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
118226287  sos2; son of sevenless homolog 2 [KO:K03099]
118226503  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118226519  jun; transcription factor AP-1 [KO:K04448]
118226705  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
118226718  [KO:K18497]
118226720  [KO:K05450]
118226898  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
118226952  [KO:K04358]
118226973  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118227020  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
118227202  [KO:K04358]
118227229  fgf7; fibroblast growth factor 7 [KO:K04358]
118227285  [KO:K04348] [EC:3.1.3.16]
118227344  [KO:K02580]
118227399  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
118227409  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
118227480  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
118227505  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
118227535  fgf3; fibroblast growth factor 3 [KO:K04358]
118227536  [KO:K04358]
118227841  igf2b; insulin-like growth factor 2b [KO:K13769]
118227870  [KO:K17333]
118227896  [KO:K02833]
118227904  [KO:K05087] [EC:2.7.10.1]
118227928  dusp8a; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8a [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118227969  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
118227979  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
118228056  casp3a; caspase-3a isoform X1 [KO:K02187] [EC:3.4.22.56]
118228077  [KO:K08018]
118228079  [KO:K07830]
118228146  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118228351  [KO:K04434]
118228903  [KO:K04345] [EC:2.7.11.11]
118228915  [KO:K04449]
118228934  [KO:K05462]
118228941  [KO:K04402]
118228983  [KO:K13377]
118229023  [KO:K04456] [EC:2.7.11.1]
118229069  [KO:K13376]
118229165  [KO:K25414]
118229166  [KO:K04379]
118229370  [KO:K04379]
118229382  [KO:K16859]
118229512  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
118229538  [KO:K04852]
118229682  max; protein max isoform X1 [KO:K04453]
118229741  [KO:K04372] [EC:2.7.11.1]
118229991  [KO:K04527] [EC:2.7.10.1]
118230044  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
118230058  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
118230091  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118230136  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118230308  [KO:K04410] [EC:2.7.11.1]
118230406  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
118230511  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118230513  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118230592  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
118230608  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
118230731  [KO:K25415]
118230824  [KO:K04457] [EC:3.1.3.16]
118230831  [KO:K04412]
118230977  kitlga; kit ligand a isoform X1 [KO:K05461]
118230988  [KO:K05460]
118231090  [KO:K02187] [EC:3.4.22.56]
118231124  [KO:K04358]
118231260  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
118231375  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
118231419  ntf3; neurotrophin-3 [KO:K04356]
118231420  [KO:K04358]
118231435  fgf23; fibroblast growth factor 23 [KO:K22428]
118231483  fgf2; fibroblast growth factor 2 [KO:K18497]
118231561  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118231624  [KO:K04348] [EC:3.1.3.16]
118231830  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
118231908  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118231977  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118231979  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
118231987  [KO:K07836]
118232005  [KO:K04365] [EC:2.7.11.1]
118232093  [KO:K04858]
118232118  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118232412  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
118232502  [KO:K02580]
118232898  [KO:K04873]
118232903  [KO:K05462]
118232938  angpt1; angiopoietin-1 [KO:K05465]
118232949  cdc42l; cell division cycle 42, like [KO:K04393]
118232957  daxx; death domain-associated protein 6 [KO:K02308]
118232991  [KO:K04872]
118233574  [KO:K16342] [EC:3.1.1.4]
118233579  [KO:K16342] [EC:3.1.1.4]
118233621  [KO:K04421] [EC:2.7.11.25]
118233779  [KO:K04388] [EC:2.7.11.30]
118234042  [KO:K04674] [EC:2.7.11.30]
118234166  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118234303  [KO:K04381]
118234304  [KO:K04381]
118234462  [KO:K04871]
118234538  [KO:K04412]
118234624  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118234664  [KO:K04393]
118234707  angpt2b; angiopoietin-2b [KO:K05466]
118234756  [KO:K04377]
118234934  [KO:K05089] [EC:2.7.10.1]
118234935  [KO:K05090] [EC:2.7.10.1]
118234937  [KO:K05449]
118234981  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
118235033  [KO:K04409] [EC:2.7.11.1]
118235128  hspb1; heat shock protein beta-1 [KO:K04455]
118235210  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118235382  [KO:K04358]
118235386  nf1b; neurofibromin isoform X1 [KO:K08052]
118235395  [KO:K04526]
118235396  [KO:K04526]
118235397  [KO:K04526]
118235421  [KO:K04419] [EC:2.7.11.25]
118235482  [KO:K12361]
118235561  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
118235568  [KO:K04373] [EC:2.7.11.1]
118235778  arrb2a; arrestin, beta 2a [KO:K04439]
118235846  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118235882  [KO:K04350]
118235937  [KO:K03283]
118235938  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
118236124  [KO:K04468] [EC:2.7.11.24]
118236139  [KO:K04440] [EC:2.7.11.24]
118236176  [KO:K04735]
118236260  [KO:K04439]
118236357  [KO:K18496]
118236409  [KO:K04373] [EC:2.7.11.1]
118236410  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118236468  [KO:K04456] [EC:2.7.11.1]
118236609  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
118236728  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
118236744  [KO:K04348] [EC:3.1.3.16]
118236769  crk; adapter molecule crk [KO:K04438]
118236785  taok1a; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
118237107  [KO:K04404]
118237163  fgf10b; fibroblast growth factor 10b [KO:K04358]
118237164  [KO:K04453]
118237168  si:dkey-246i14.3; ephrin-A4 isoform X2 [KO:K05462]
118237185  [KO:K05121] [EC:2.7.10.1]
118237282  [KO:K04348] [EC:3.1.3.16]
118237323  [KO:K09784]
118237341  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118237363  [KO:K04438]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
aang04070  Phosphatidylinositol signaling system
aang04110  Cell cycle
aang04115  p53 signaling pathway
aang04210  Apoptosis
aang04310  Wnt signaling pathway
KO pathway
ko04010   

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