KEGG   PATHWAY: aju04924
Entry
aju04924                    Pathway                                
Name
Renin secretion - Acinonyx jubatus (cheetah)
Description
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class
Organismal Systems; Endocrine system
Pathway map
aju04924  Renin secretion
aju04924

Other DBs
GO: 0002001
Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
113600301  beta-1 adrenergic receptor [KO:K04141]
106981678  beta-2 adrenergic receptor [KO:K04142]
113602685  beta-3 adrenergic receptor isoform X1 [KO:K04143]
106965762  pituitary adenylate cyclase-activating polypeptide isoform X2 [KO:K05262]
106968665  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2 [KO:K04587]
106968667  aquaporin-1 [KO:K09864]
106981938  prostaglandin E2 receptor EP2 subtype [KO:K04259]
106970912  prostaglandin E2 receptor EP4 subtype [KO:K04261]
106969942  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
106969924  neuroendocrine secretory protein 55 [KO:K04632]
106984082  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
106969297  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
106973352  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106985791  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106967098  cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
106969710  calcium-activated potassium channel subunit alpha-1 isoform X16 [KO:K04936]
106988438  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
106968663  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
106982818  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
106977145  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
106989114  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
106972902  renin [KO:K01380] [EC:3.4.23.15]
106971862  adenosine receptor A1 [KO:K04265]
106977809  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
106982494  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106967590  calcium release-activated calcium channel protein 1 [KO:K16056]
106973315  calcium-activated chloride channel regulator 1 [KO:K05027]
106973316  calcium-activated chloride channel regulator 2 isoform X1 [KO:K05028]
106973313  calcium-activated chloride channel regulator 1-like [KO:K05030]
106973307  LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 4 [KO:K05030]
106965473  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
106986998  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106988999  voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
106974264  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
106984837  inward rectifier potassium channel 2 [KO:K04996]
106974187  endothelin-1 [KO:K16366]
106966971  endothelin-2 [KO:K16367]
106969938  endothelin-3 isoform X1 [KO:K05227]
106983346  endothelin-1 receptor [KO:K04197]
106975222  type-1 angiotensin II receptor [KO:K04166]
106975317  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106976431  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
106976432  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
106981698  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
106968579  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
106978946  inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
106968786  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
106976077  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
106980445  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
106987911  calmodulin-1 [KO:K02183]
106977221  calmodulin-2 [KO:K02183]
106984637  calmodulin-like protein 6 isoform X1 [KO:K02183]
106973635  calmodulin-3 [KO:K02183]
106988136  calmodulin-like protein 3 [KO:K02183]
106988135  calmodulin-like [KO:K02183]
106970974  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106982482  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
106981120  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106967692  calcineurin subunit B type 1 [KO:K06268]
106972076  calcineurin subunit B type 2 [KO:K06268]
106983909  guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
106982463  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
106982460  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
106971865  natriuretic peptides A [KO:K12334]
106987270  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
106976911  cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
106975817  cathepsin B isoform X3 [KO:K01363] [EC:3.4.22.1]
106983558  angiotensinogen [KO:K09821]
106978683  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
106978669  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00020  AMP
C00076  Calcium cation
C00212  Adenosine
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00788  L-Adrenaline
C00873  Angiotensin I
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02135  Angiotensin II
Reference
PMID:20936939
  Authors
Kurtz A
  Title
Renin release: sites, mechanisms, and control.
  Journal
Annu Rev Physiol 73:377-99 (2011)
DOI:10.1146/annurev-physiol-012110-142238
Reference
PMID:17928544
  Authors
Schweda F, Friis U, Wagner C, Skott O, Kurtz A
  Title
Renin release.
  Journal
Physiology (Bethesda) 22:310-9 (2007)
DOI:10.1152/physiol.00024.2007
Reference
PMID:20393195
  Authors
Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
  Title
Physiology of kidney renin.
  Journal
Physiol Rev 90:607-73 (2010)
DOI:10.1152/physrev.00011.2009
Reference
PMID:22733355
  Authors
Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
  Title
Regulation of renin secretion by renal juxtaglomerular cells.
  Journal
Pflugers Arch 465:25-37 (2013)
DOI:10.1007/s00424-012-1126-7
Reference
PMID:22124804
  Authors
Kim SM, Briggs JP, Schnermann J
  Title
Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
  Journal
Clin Exp Nephrol 16:17-24 (2012)
DOI:10.1007/s10157-011-0494-1
Reference
PMID:22237158
  Authors
Kurtz A
  Title
Control of renin synthesis and secretion.
  Journal
Am J Hypertens 25:839-47 (2012)
DOI:10.1038/ajh.2011.246
Reference
PMID:9882634
  Authors
Kurtz A, Wagner C
  Title
Cellular control of renin secretion.
  Journal
J Exp Biol 202:219-25 (1999)
Reference
PMID:12949225
  Authors
Persson PB
  Title
Renin: origin, secretion and synthesis.
  Journal
J Physiol 552:667-71 (2003)
DOI:10.1113/jphysiol.2003.049890
Reference
PMID:15283749
  Authors
Schweda F, Kurtz A
  Title
Cellular mechanism of renin release.
  Journal
Acta Physiol Scand 181:383-90 (2004)
DOI:10.1111/j.1365-201X.2004.01309.x
Reference
PMID:24944035
  Authors
Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
  Title
Classical Renin-Angiotensin system in kidney physiology.
  Journal
Compr Physiol 4:1201-28 (2014)
DOI:10.1002/cphy.c130040
Reference
PMID:19948673
  Authors
Harrison-Bernard LM
  Title
The renal renin-angiotensin system.
  Journal
Adv Physiol Educ 33:270-4 (2009)
DOI:10.1152/advan.00049.2009
Reference
PMID:22258323
  Authors
Schnermann J, Briggs JP
  Title
Synthesis and secretion of renin in mice with induced genetic mutations.
  Journal
Kidney Int 81:529-38 (2012)
DOI:10.1038/ki.2011.451
Reference
PMID:12388321
  Authors
Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
  Title
Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
  Journal
Am J Physiol Heart Circ Physiol 283:H2458-65 (2002)
DOI:10.1152/ajpheart.00295.2002
Reference
PMID:17360952
  Authors
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
  Title
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
  Journal
J Am Soc Nephrol 18:1150-6 (2007)
DOI:10.1681/ASN.2006060633
Related
pathway
aju04020  Calcium signaling pathway
aju04022  cGMP-PKG signaling pathway
aju04024  cAMP signaling pathway
aju04614  Renin-angiotensin system
KO pathway
ko04924   
LinkDB

DBGET integrated database retrieval system