KEGG   PATHWAY: amj00830
Entry
amj00830                    Pathway                                
Name
Retinol metabolism - Alligator mississippiensis (American alligator)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
amj00830  Retinol metabolism
amj00830

Other DBs
GO: 0006776
Organism
Alligator mississippiensis (American alligator) [GN:amj]
Gene
102573601  BCO1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]
102562002  ADH1C; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
102566719  ADH5; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
102566949  ADH4; alcohol dehydrogenase 4 [KO:K13980] [EC:1.1.1.1]
106737174  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
102574201  DHRS3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
102562999  DHRS4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
102564851  DHRS9; dehydrogenase/reductase 9 [KO:K11149] [EC:1.1.-.-]
102562085  retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
106737211  RDH8; retinol dehydrogenase 8 (all-trans) [KO:K11150] [EC:1.1.1.-]
102575562  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
102567292  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
102572166  retinol dehydrogenase 3-like [KO:K11154] [EC:1.1.1.-]
109285947  epidermal retinol dehydrogenase 2-like [KO:K15734] [EC:1.1.1.105]
102563664  epidermal retinol dehydrogenase 2-like [KO:K15734] [EC:1.1.1.105]
102563418  epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
102577108  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
102567845  17-beta-hydroxysteroid dehydrogenase type 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
102557704  LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) [KO:K00678] [EC:2.3.1.135]
102576196  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
102561661  PNPLA4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]
102560040  RPE65; RPE65, retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
102572099  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
102558513  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
102557817  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
102558282  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
102558050  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
102558250  ALDH1A2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]
102571914  ALDH1A1; aldehyde dehydrogenase 1 family member A1 [KO:K07249] [EC:1.2.1.36]
102573093  ALDH1A3; aldehyde dehydrogenase 1 family member A3 [KO:K07249] [EC:1.2.1.36]
102575941  CYP26A1; cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
102567612  CYP26B1; cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
102577027  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
102572949  cytochrome P450 2C5 [KO:K07413] [EC:1.14.14.1]
102573618  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
102573559  cytochrome P450 2C18-like [KO:K07413] [EC:1.14.14.1]
102570482  CYP3A; cytochrome P450 3A21 [KO:K07424] [EC:1.14.14.1]
102570712  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
102574494  cytochrome P450 2W1-like [KO:K07423] [EC:1.14.14.-]
102558477  UGT1A1; UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]
102568629  UGT2A3; UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
102576004  RETSAT; retinol saturase [KO:K09516] [EC:1.3.99.23]
102574953  CYP27C1; cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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