KEGG   PATHWAY: aoce00260
Entry
aoce00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Amphiprion ocellaris (clown anemonefish)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aoce00260  Glycine, serine and threonine metabolism
aoce00260

Module
aoce_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aoce00260]
aoce_M00047  Creatine pathway [PATH:aoce00260]
aoce_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:aoce00260]
aoce_M00555  Betaine biosynthesis, choline => betaine [PATH:aoce00260]
aoce_M00621  Glycine cleavage system [PATH:aoce00260]
aoce_M00974  Betaine metabolism, animals, betaine => glycine [PATH:aoce00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Amphiprion ocellaris (clown anemonefish) [GN:aoce]
Gene
111585916  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
111585917  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
111570318  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
111582037  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
111565034  agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
111578809  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
111567851  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
111572164  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
111585432  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
111564371  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
111572233  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
111565727  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
111571862  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
111567052  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
111579197  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
111580747  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
111564746  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
111575487  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
111562792  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
111578480  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
111578791  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
111586383  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
111578048  5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
111583481  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
111588726  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
111563864  maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
111579096  probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
111562456  primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
111562457  primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
111580398  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
111570010  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
111567523  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
111571135  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
111582522  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
111588560  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
111587894  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
111578671  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
111563874  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
111582783  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
111584411  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
111565984  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
111564721  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
111564722  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
111570352  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
111581621  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
111581625  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
111570345  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
111572794  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
111567010  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
111562587  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
111568100  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
111579459  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
111584154  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
111569365  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
111573990  L-threo-3-hydroxyaspartate ammonia-lyase-like [KO:K01754] [EC:4.3.1.19]
111581700  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
111580376  sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
111571317  uncharacterized protein LOC111571317 [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aoce00010  Glycolysis / Gluconeogenesis
aoce00020  Citrate cycle (TCA cycle)
aoce00230  Purine metabolism
aoce00250  Alanine, aspartate and glutamate metabolism
aoce00270  Cysteine and methionine metabolism
aoce00290  Valine, leucine and isoleucine biosynthesis
aoce00330  Arginine and proline metabolism
aoce00470  D-Amino acid metabolism
aoce00564  Glycerophospholipid metabolism
aoce00600  Sphingolipid metabolism
aoce00620  Pyruvate metabolism
aoce00630  Glyoxylate and dicarboxylate metabolism
aoce00640  Propanoate metabolism
aoce00860  Porphyrin metabolism
aoce00920  Sulfur metabolism
KO pathway
ko00260   
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