KEGG   PATHWAY: aoce03440
Entry
aoce03440                   Pathway                                
Name
Homologous recombination - Amphiprion ocellaris (clown anemonefish)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
aoce03440  Homologous recombination
aoce03440

Other DBs
GO: 0000724
Organism
Amphiprion ocellaris (clown anemonefish) [GN:aoce]
Gene
111564576  ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
111574491  rad50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
111587757  mre11; double-strand break repair protein MRE11 [KO:K10865]
111582978  nbn; nibrin isoform X1 [KO:K10867]
111588942  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
111567306  brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
111572887  bard1; BRCA1-associated RING domain protein 1 [KO:K10683]
111587086  rbbp8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
111581228  brip1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
111563836  topbp1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
111571150  abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
111571335  uimc1; BRCA1-A complex subunit RAP80 [KO:K20775]
111586257  uncharacterized protein LOC111586257 [KO:K20775]
111580193  babam1; BRISC and BRCA1-A complex member 1 [KO:K20776]
111571190  babam2; BRISC and BRCA1-A complex member 2 [KO:K12173]
111581320  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
111566265  palb2; partner and localizer of BRCA2 [KO:K10897]
111563668  brca2; breast cancer type 2 susceptibility protein [KO:K08775]
111579027  sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
111586546  sycp3; synaptonemal complex protein 3 [KO:K19528]
111588250  replication protein A 70 kDa DNA-binding subunit-like isoform X1 [KO:K07466]
111569726  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
111563381  rpa2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]
111573414  replication protein A 32 kDa subunit-like [KO:K10739]
111575174  rpa3; replication protein A 14 kDa subunit [KO:K10740]
111580833  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
111588143  rad52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
111575168  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
111571484  rad51d; DNA repair protein RAD51 homolog 4 [KO:K10871]
111582787  xrcc2; DNA repair protein XRCC2 [KO:K10879]
111574978  xrcc3; DNA repair protein XRCC3 [KO:K10880]
111564063  rad54l; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
111586363  rad54b; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
111565346  pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
111575031  pold2; DNA polymerase delta subunit 2 [KO:K02328]
111582849  pold3; DNA polymerase delta subunit 3 [KO:K03504]
111570672  pold4; DNA polymerase delta subunit 4 [KO:K03505]
111580160  blm; Bloom syndrome protein isoform X1 [KO:K10901] [EC:5.6.2.4]
111570324  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
111570528  top3b; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
111584519  mus81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
111566083  eme1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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