KEGG   PATHWAY: apri04530
Entry
apri04530                   Pathway                                
Name
Tight junction - Ahaetulla prasina (Asian vine snake)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
apri04530  Tight junction
apri04530

Other DBs
GO: 0005923
Organism
Ahaetulla prasina (Asian vine snake) [GN:apri]
Gene
131188894  CLDN3; claudin-3 [KO:K06087]
131188895  CLDN4; claudin-4 [KO:K06087]
131200777  CLDN11; claudin-11 [KO:K06087]
131201210  CLDN1; claudin-1 [KO:K06087]
131201306  claudin-15-like [KO:K06087]
131201350  CLDN16; claudin-16 [KO:K06087]
131201495  CLDN18; claudin-18 [KO:K06087]
131185311  claudin-34-like [KO:K06087]
131191194  CLDN20; claudin-20 [KO:K06087]
131203024  claudin-22-like [KO:K06087]
131185492  CLDN5; claudin-5 [KO:K06087]
131197689  claudin-9-like [KO:K06087]
131203800  CLDN25; putative claudin-25 [KO:K06087]
131198684  claudin-4-like [KO:K06087]
131198698  CLDN7; claudin-7 [KO:K06087]
131186994  CLDN19; claudin-19 [KO:K06087]
131187208  claudin-16-like [KO:K06087]
131198771  CLDN12; claudin-12 [KO:K06087]
131198827  CLDN15; claudin-15 [KO:K06087]
131193295  CLDN23; claudin-23 isoform X1 [KO:K06087]
131199310  CLDN8; claudin-8 [KO:K06087]
131199311  claudin-17-like [KO:K06087]
131205127  CLDN2; claudin-2 [KO:K06087]
131188043  claudin-like protein ZF-A89 [KO:K06087]
131199877  CLDN10; claudin-10 [KO:K06087]
131200162  CLDN14; claudin-14 [KO:K06087]
131191140  OCLN; occludin [KO:K06088]
131188411  occludin-like isoform X1 [KO:K06088]
131186458  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
131199772  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
131203875  junctional adhesion molecule C-like [KO:K06785]
131194040  BVES; blood vessel epicardial substance [KO:K21108]
131187056  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131195573  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
131195610  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
131184352  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
131187501  PALS1; protein PALS1 isoform X1 [KO:K06091]
131200467  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
131188304  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
131196206  PATJ; inaD-like protein isoform X1 [KO:K06092]
131190699  MPDZ; multiple PDZ domain protein [KO:K06095]
131187079  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
131201452  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
131204998  AMOT; angiomotin [KO:K16819]
131199283  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
131200347  AMOTL2; angiomotin-like protein 2 [KO:K06104]
131185096  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
131184996  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
131188875  merlin-like [KO:K16684]
131185666  NF2; merlin isoform X1 [KO:K16684]
131184987  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
131191130  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
131200565  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
131196343  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
131191022  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
131192569  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
131204438  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
131200701  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
131202956  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1 [KO:K04354]
131203829  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
131192118  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
131197528  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
131199175  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
131184520  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
131188558  tight junction-associated protein 1-like isoform X1 [KO:K06105]
131200001  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
131205129  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
131191883  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
131186568  cingulin-like [KO:K06102]
131184557  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
131186366  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
131189979  RHOA; transforming protein RhoA [KO:K04513]
131190059  transforming protein RhoA-like [KO:K04513]
131188860  GATA4; transcription factor GATA-4 [KO:K09183]
131194550  MARVEL domain-containing protein 3-like [KO:K21099]
131190845  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
131202781  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
131200243  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131193919  JUN; transcription factor Jun [KO:K04448]
131202459  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
131192160  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
131204290  SYMPK; symplekin [KO:K06100]
131187188  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
131198329  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
131199548  RUNX1; runt-related transcription factor 1 [KO:K08367]
131191327  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
131189476  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
131190953  EZR; ezrin [KO:K08007]
131199903  RDX; radixin isoform X1 [KO:K05762]
131204964  MSN; moesin [KO:K05763]
131189216  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
131201107  ACTRT3; actin-related protein T3 isoform X1 [KO:K05692]
131189833  ACTG1; actin, cytoplasmic 2 [KO:K05692]
131185411  ACTB; actin, cytoplasmic 1 [KO:K05692]
131192185  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
131192139  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
131189657  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
131196195  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
131187274  CTTN; src substrate cortactin isoform X1 [KO:K06106]
131197815  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
131186560  actin-related protein 2-like isoform X1 [KO:K17260]
131197687  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
131203768  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
131185180  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
131185367  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
131185866  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
131192423  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
131195572  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
131186235  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
131184575  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
131193272  WAS; actin nucleation-promoting factor WAS [KO:K05747]
131204767  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
131189981  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
131194596  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
131186342  RAB13; ras-related protein Rab-13 [KO:K06109]
131188175  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
131196381  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
131196144  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
131185562  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
131188327  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
131195246  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
131191632  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
131196385  5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
131185628  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
131191314  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
131198741  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
131201796  MYH9; myosin-9 [KO:K10352]
131185052  MYH11; myosin-11 isoform X1 [KO:K10352]
131196716  myosin-10-like isoform X1 [KO:K10352]
131191060  MYH10; myosin-10 isoform X1 [KO:K10352]
131191981  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
131194505  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
131194528  MYL12B; myosin regulatory light chain 12B isoform X1 [KO:K12757]
131199765  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
131193555  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
131190320  SYNPO; synaptopodin [KO:K21112]
131204203  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
131187522  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
131185277  MICALL2; MICAL-like protein 2 [KO:K21068]
131188143  RAB8A; ras-related protein Rab-8A [KO:K07901]
131184599  RAB8B; ras-related protein Rab-8B [KO:K07902]
131190944  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
131196661  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
131190394  AFDN; afadin isoform X1 [KO:K05702]
131191015  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
131203444  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
131205003  RAP2C; ras-related protein Rap-2c [KO:K07839]
131191092  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
131188386  OCEL1; occludin/ELL domain-containing protein 1 [KO:K17291]
131201440  tubulin alpha-3 chain [KO:K07374]
131202303  tubulin alpha-8 chain [KO:K07374]
131202367  tubulin alpha-8 chain-like [KO:K07374]
131202413  tubulin alpha-3 chain-like [KO:K07374]
131202678  tubulin alpha-3 chain [KO:K07374]
131191102  TUBA1C; tubulin alpha-1C chain [KO:K07374]
131191622  TUBA1A; tubulin alpha-1A chain [KO:K07374]
131191896  TUBA1B; tubulin alpha-1B chain [KO:K07374]
131194611  tubulin alpha-8 chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
apri04520  Adherens junction
apri04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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