KEGG   PATHWAY: arut00260
Entry
arut00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Acipenser ruthenus (sterlet)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
arut00260  Glycine, serine and threonine metabolism
arut00260

Module
arut_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:arut00260]
arut_M00047  Creatine pathway [PATH:arut00260]
arut_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:arut00260]
arut_M00555  Betaine biosynthesis, choline => betaine [PATH:arut00260]
arut_M00621  Glycine cleavage system [PATH:arut00260]
arut_M00974  Betaine metabolism, animals, betaine => glycine [PATH:arut00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117424439  tha1; threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
117973744  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
117966997  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
117401100  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
117417217  serine--pyruvate aminotransferase, mitochondrial [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
117423424  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
117420848  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
117421534  glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
117412255  glycerate kinase [KO:K11529] [EC:2.7.1.165]
117963513  glycerate kinase-like [KO:K11529] [EC:2.7.1.165]
117397785  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
117418296  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
117966109  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
117414807  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
117966475  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
117419669  bisphosphoglycerate mutase-like [KO:K01837] [EC:5.4.2.4 5.4.2.11]
117415332  bisphosphoglycerate mutase-like [KO:K01837] [EC:5.4.2.4 5.4.2.11]
117426220  D-3-phosphoglycerate dehydrogenase-like isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
117404859  D-3-phosphoglycerate dehydrogenase-like isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
117420734  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
117429096  phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]
117430722  phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]
117410504  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
117402212  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
117413232  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
117414072  L-threonine 3-dehydrogenase, mitochondrial-like isoform X3 [KO:K15789] [EC:1.1.1.103]
117962350  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
117401600  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
117404307  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
117414238  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
117407136  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
117430315  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
117411679  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
117409562  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
117411868  aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
117962420  aminomethyltransferase, mitochondrial-like isoform X1 [KO:K00605] [EC:2.1.2.10]
117419633  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
117414892  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
117424729  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
117425421  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
117973385  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
117428576  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
117420681  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
117962314  glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
117429023  glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
117401388  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
117966392  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
117971355  choline dehydrogenase, mitochondrial-like [KO:K00108] [EC:1.1.99.1]
117411968  choline dehydrogenase, mitochondrial-like isoform X1 [KO:K00108] [EC:1.1.99.1]
117418586  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
117409000  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
117974146  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
117403613  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
117404061  dimethylglycine dehydrogenase, mitochondrial-like [KO:K00315] [EC:1.5.8.4]
117403612  dimethylglycine dehydrogenase, mitochondrial-like [KO:K00315] [EC:1.5.8.4]
117429317  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
117963315  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
117396956  LOW QUALITY PROTEIN: sarcosine dehydrogenase, mitochondrial-like [KO:K00314] [EC:1.5.8.3]
117422502  LOW QUALITY PROTEIN: sarcosine dehydrogenase, mitochondrial-like [KO:K00314] [EC:1.5.8.3]
117411412  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
117402945  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
117406668  cbsa; cystathionine beta-synthase a isoform X1 [KO:K01697] [EC:4.2.1.22]
117400188  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
117418133  L-threonine ammonia-lyase-like isoform X1 [KO:K01754] [EC:4.3.1.19]
117415310  L-threonine ammonia-lyase-like isoform X1 [KO:K01754] [EC:4.3.1.19]
117428431  serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
117426937  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
117426939  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
117428433  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
117414223  zgc:162816; LOW QUALITY PROTEIN: D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
arut00010  Glycolysis / Gluconeogenesis
arut00020  Citrate cycle (TCA cycle)
arut00230  Purine metabolism
arut00250  Alanine, aspartate and glutamate metabolism
arut00270  Cysteine and methionine metabolism
arut00290  Valine, leucine and isoleucine biosynthesis
arut00300  Lysine biosynthesis
arut00330  Arginine and proline metabolism
arut00470  D-Amino acid metabolism
arut00564  Glycerophospholipid metabolism
arut00600  Sphingolipid metabolism
arut00620  Pyruvate metabolism
arut00630  Glyoxylate and dicarboxylate metabolism
arut00640  Propanoate metabolism
arut00860  Porphyrin metabolism
arut00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system