KEGG   PATHWAY: bom00260
Entry
bom00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bos mutus (wild yak)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bom00260  Glycine, serine and threonine metabolism
bom00260

Module
bom_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bom00260]
bom_M00047  Creatine pathway [PATH:bom00260]
bom_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:bom00260]
bom_M00555  Betaine biosynthesis, choline => betaine [PATH:bom00260]
bom_M00621  Glycine cleavage system [PATH:bom00260]
bom_M00974  Betaine metabolism, animals, betaine => glycine [PATH:bom00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bos mutus (wild yak) [GN:bom]
Gene
102276152  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
102273549  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
102287065  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
102268165  AGXT; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
102267118  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102272865  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
102271561  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
102286777  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
102272524  PGAM4; phosphoglycerate mutase family member 4 [KO:K01834] [EC:5.4.2.11]
102275503  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102270409  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102275256  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102285424  bisphosphoglycerate mutase-like [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102273801  PHGDH; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102287698  PSAT1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]
102267174  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
102283106  GCAT; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
102283236  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
102273625  ALAS1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]
102265037  ALAS2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]
102278499  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
102278212  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
102287961  primary amine oxidase, liver isozyme [KO:K00276] [EC:1.4.3.21]
102273527  AOC2; amine oxidase, copper containing 2 [KO:K00276] [EC:1.4.3.21]
102273246  AOC3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
102267937  primary amine oxidase, liver isozyme [KO:K00276] [EC:1.4.3.21]
102286520  GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
102268408  AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
102277665  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
102282421  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
102265843  GCSH; glycine cleavage system protein H [KO:K02437]
102288350  DAO; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
102269782  AGXT2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102274253  GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
102277266  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
102276474  CHDH; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
102285292  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
102286920  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
102287393  DMGDH; dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
102271306  PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
102286478  SARDH; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]
102287446  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
102285677  CBS; cystathionine-beta-synthase [KO:K01697] [EC:4.2.1.22]
102269372  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
102286598  SDS; serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102286891  SDSL; serine dehydratase like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102268037  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bom00010  Glycolysis / Gluconeogenesis
bom00020  Citrate cycle (TCA cycle)
bom00230  Purine metabolism
bom00250  Alanine, aspartate and glutamate metabolism
bom00270  Cysteine and methionine metabolism
bom00290  Valine, leucine and isoleucine biosynthesis
bom00330  Arginine and proline metabolism
bom00470  D-Amino acid metabolism
bom00564  Glycerophospholipid metabolism
bom00600  Sphingolipid metabolism
bom00620  Pyruvate metabolism
bom00630  Glyoxylate and dicarboxylate metabolism
bom00640  Propanoate metabolism
bom00860  Porphyrin metabolism
bom00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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