KEGG   PATHWAY: caty00260
Entry
caty00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Cercocebus atys (sooty mangabey)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
caty00260  Glycine, serine and threonine metabolism
caty00260

Module
caty_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:caty00260]
caty_M00047  Creatine pathway [PATH:caty00260]
caty_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:caty00260]
caty_M00555  Betaine biosynthesis, choline => betaine [PATH:caty00260]
caty_M00621  Glycine cleavage system [PATH:caty00260]
caty_M00974  Betaine metabolism, animals, betaine => glycine [PATH:caty00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105587265  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
105598218  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
105577403  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
105593083  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
105585552  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
105578551  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105588421  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
105589193  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105581932  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
105596916  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
105598140  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105599723  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105589610  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
105599581  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
105584213  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
105571979  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
105575841  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
105579382  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
105585547  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
105598645  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
105590551  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
105590553  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
105579692  AOC3; membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
105579693  AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
105584070  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
105573692  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
105583131  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
105592420  glycine cleavage system H protein, mitochondrial [KO:K02437]
105589402  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
105573229  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
105583414  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
105588183  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
105591715  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
105585591  CHDH; choline dehydrogenase, mitochondrial isoform X1 [KO:K00108] [EC:1.1.99.1]
105599693  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
105599167  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
105599277  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
105591541  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
105578092  LOW QUALITY PROTEIN: sarcosine dehydrogenase, mitochondrial-like [KO:K00314] [EC:1.5.8.3]
105580522  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
105591544  GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
105575589  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
105595872  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
105592721  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105573150  SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105584078  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
caty00010  Glycolysis / Gluconeogenesis
caty00020  Citrate cycle (TCA cycle)
caty00230  Purine metabolism
caty00250  Alanine, aspartate and glutamate metabolism
caty00270  Cysteine and methionine metabolism
caty00290  Valine, leucine and isoleucine biosynthesis
caty00330  Arginine and proline metabolism
caty00470  D-Amino acid metabolism
caty00564  Glycerophospholipid metabolism
caty00600  Sphingolipid metabolism
caty00620  Pyruvate metabolism
caty00630  Glyoxylate and dicarboxylate metabolism
caty00640  Propanoate metabolism
caty00860  Porphyrin metabolism
caty00920  Sulfur metabolism
KO pathway
ko00260   
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