KEGG   PATHWAY: ccw04150
Entry
ccw04150                    Pathway                                
Name
mTOR signaling pathway - Corvus cornix (hooded crow)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ccw04150  mTOR signaling pathway
ccw04150

Organism
Corvus cornix (hooded crow) [GN:ccw]
Gene
104691918  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104686672  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
104687098  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104694843  ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
104685440  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
104692705  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104683864  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104692248  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
120411927  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
104688445  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104695413  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104690391  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
104687166  LAMTOR1; LOW QUALITY PROTEIN: ragulator complex protein LAMTOR1 [KO:K20397]
104697284  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104692429  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
104684782  FLCN; folliculin [KO:K09594]
104697987  FNIP1; folliculin-interacting protein 1 isoform X2 [KO:K20400]
104697192  FNIP2; folliculin-interacting protein 2 isoform X2 [KO:K20401]
104691600  ras-related GTP-binding protein A isoform X2 [KO:K16185]
104692301  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
104695031  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
104695774  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
104689151  MIOS; GATOR complex protein MIOS [KO:K20407]
104684935  WDR24; LOW QUALITY PROTEIN: GATOR complex protein WDR24 [KO:K20408]
104687509  WDR59; GATOR complex protein WDR59 isoform X2 [KO:K20409]
104683400  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
104688563  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
104683213  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
104684686  NPRL3; GATOR complex protein NPRL3 isoform X5 [KO:K20406]
104686606  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
104689831  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
104698217  RPTOR; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
104693234  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
104692669  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
104687659  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
104684994  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104684635  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
104687851  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
104688827  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
104685861  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
104685433  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
104687300  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
104687885  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
104688633  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
104691021  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
104694846  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
104687965  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
104689524  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
104697282  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104691002  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
104685276  RPS6; 40S ribosomal protein S6 [KO:K02991]
104698633  STRADA; STE20-related kinase adapter protein alpha isoform X3 [KO:K08271]
104693780  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
104697015  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104689966  CAB39L; calcium-binding protein 39-like [KO:K08272]
104693045  CAB39; calcium-binding protein 39 [KO:K08272]
104695510  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
104686759  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104688322  TSC1; hamartin isoform X5 [KO:K07206]
104684745  TSC2; tuberin isoform X1 [KO:K07207]
104691404  TBC1 domain family member 7 isoform X1 [KO:K20396]
104686511  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
120410238  DDIT4; LOW QUALITY PROTEIN: DNA damage-inducible transcript 4 protein [KO:K08270]
104692318  WNT2B; LOW QUALITY PROTEIN: protein Wnt-2b [KO:K00182]
104698447  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
104686382  WNT3A; protein Wnt-3a [KO:K00312]
104698529  WNT3; proto-oncogene Wnt-3 [KO:K00312]
104697541  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
104692240  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
104683261  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
104693964  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
104695759  WNT7A; protein Wnt-7a [KO:K00572]
104696093  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
104696979  WNT8B; protein Wnt-8b [KO:K00714]
104686381  WNT9A; protein Wnt-9a [KO:K01064]
104698528  WNT9B; protein Wnt-9b [KO:K01064]
104694193  WNT10A; protein Wnt-10a [KO:K01357]
104686964  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
104691341  protein Wnt-11b-like [KO:K01384]
104686900  WNT16; protein Wnt-16 [KO:K01558]
104689341  FZD1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
104693786  FZD7; frizzled-7 [KO:K02432]
104698542  FZD2; LOW QUALITY PROTEIN: frizzled-2 [KO:K02235]
104696888  FZD3; frizzled-3 isoform X2 [KO:K02329]
104690317  FZD4; frizzled-4 [KO:K02354]
104686527  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
104694145  FZD5; frizzled-5 [KO:K02375]
104692703  FZD6; frizzled-6 isoform X2 [KO:K02376]
104688742  FZD10; frizzled-10 [KO:K02842]
120411028  FZD9; frizzled-9 [KO:K02842]
104696102  LRP6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068]
104692657  LRP5; low-density lipoprotein receptor-related protein 5 isoform X2 [KO:K03068]
104687975  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X3 [KO:K02353]
104693398  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
104687192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104687033  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104694916  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104687554  insulin [KO:K04526]
104696228  IGF1; insulin-like growth factor I [KO:K05459]
104696982  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
104684080  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
104694312  GRB2; LOW QUALITY PROTEIN: growth factor receptor-bound protein 2 [KO:K04364]
104695922  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
104696641  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
104691739  HRAS; GTPase HRas [KO:K02833]
104696163  KRAS; GTPase KRas isoform X1 [KO:K07827]
104692410  NRAS; GTPase NRas [KO:K07828]
104696191  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104695743  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104683880  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104697410  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104688782  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104686187  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104691302  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
104684342  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
109145556  IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172]
104695234  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104686712  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104696977  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104688020  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104693039  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104693336  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104695072  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104684909  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
104684403  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
104687008  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104695067  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104688396  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
104686621  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
104696077  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
104693862  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
104683253  RHOA; transforming protein RhoA [KO:K04513]
104696032  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104684988  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104690470  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ccw00561  Glycerolipid metabolism
ccw04010  MAPK signaling pathway
ccw04140  Autophagy - animal
ccw04810  Regulation of actin cytoskeleton
ccw04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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