KEGG PATHWAY: ccx00270

PATHWAY: ccx00270

Entry

ccx00270                    Pathway

Name

Cysteine and methionine metabolism - Corallococcus coralloides

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

ccx00270

Cysteine and methionine metabolism

Module

ccx_M00021

Cysteine biosynthesis, serine => cysteine [PATH:ccx00270]

ccx_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ccx00270]

Other DBs

GO:	0006534 0006555

Organism

Corallococcus coralloides [GN:ccx]

Gene

COCOR_03005

cysE; hexapeptide repeat-containing transferase [KO:K00640] [EC:2.3.1.30]

COCOR_06306

nifP; putative serine acetyltransferase [KO:K00640] [EC:2.3.1.30]

COCOR_08056

cysE1; hexapeptide repeat-containing transferase [KO:K00640] [EC:2.3.1.30]

COCOR_01589

srpH; putative serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

COCOR_00928

cysK1; putative cysteine synthase [KO:K01738] [EC:2.5.1.47]

COCOR_01588

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

COCOR_02773

cbs; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

COCOR_06056

metB1; Cys/Met metabolism PLP-dependent enzyme [KO:K01758] [EC:4.4.1.1]

COCOR_06049

cbs1; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

COCOR_01995

metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]

COCOR_07116

metK; S-adenosylmethionine synthetase [KO:K00789] [EC:2.5.1.6]

COCOR_01130

speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

COCOR_05804

speE; putative lipoprotein [KO:K00797] [EC:2.5.1.16]

COCOR_01134

speE1; spermidine synthase [KO:K00797] [EC:2.5.1.16]

COCOR_02369

speE2; spermine/spermidine synthase family protein [KO:K00797] [EC:2.5.1.16]

COCOR_06482

xapA; methylthioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]

COCOR_07001

mtaP; 5-methylthioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]

COCOR_05060

hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

COCOR_06183

mtaD2; N-ethylammeline chlorohydrolase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

COCOR_06879

mtaD3; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

COCOR_02291

mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

COCOR_02379

mtaD1; amidohydrolase domain-containing protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

COCOR_07000

mtnA; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

COCOR_07004

mtnB; methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

COCOR_07002

masA; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase [KO:K09880] [EC:3.1.3.77]

COCOR_07003

mtnD; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

COCOR_03080

hypothetical protein [KO:K08968] [EC:1.8.4.14]

COCOR_06726

ahcY; S-adenosyl-L-homocysteine hydrolase [KO:K01251] [EC:3.13.2.1]

COCOR_04658

lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]

COCOR_02555

ask; aspartate kinase [KO:K00928] [EC:2.7.2.4]

COCOR_00009

thrA; aspartate kinase/homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]

COCOR_06423

thrA1; aspartate kinase/homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]

COCOR_04993

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

COCOR_05530

asd1; semialdehyde dehydrogenase family protein [KO:K00133] [EC:1.2.1.11]

COCOR_05006

hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

COCOR_01390

homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

COCOR_06422

metX1; putative homoserine-O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

COCOR_01983

mdeA; Cys/Met metabolism PLP-dependent enzyme [KO:K01739] [EC:2.5.1.48]

COCOR_06421

mdeA1; O-acetylhomoserine sulfhydrylase [KO:K01740] [EC:2.5.1.49]

COCOR_05070

ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

COCOR_06316

gshA; glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]

COCOR_00025

gshB; glutathione synthase [KO:K01920] [EC:6.3.2.3]

COCOR_08090

hypothetical protein [KO:K00456] [EC:1.13.11.20]

COCOR_03253

aatA; putative aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

COCOR_00470

aatB; class I aminotransferase [KO:K00812] [EC:2.6.1.1]

COCOR_02790

aspartate aminotransferase [KO:K09758] [EC:4.1.1.12]

COCOR_03243

ygeA; aspartate racemase [KO:K25316] [EC:5.1.1.10]

COCOR_04502

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

COCOR_06650

sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]

COCOR_05275

hypothetical protein [KO:K12339] [EC:2.5.1.144]

COCOR_06971

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

COCOR_03302

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01102

O-Phospho-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors