KEGG PATHWAY: cfa00260

PATHWAY: cfa00260

Entry

cfa00260                    Pathway

Name

Glycine, serine and threonine metabolism - Canis lupus familiaris (dog)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

cfa00260

Glycine, serine and threonine metabolism

Module

cfa_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:cfa00260]

cfa_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cfa00260]

cfa_M00555

Betaine biosynthesis, choline => betaine [PATH:cfa00260]

cfa_M00621

Glycine cleavage system [PATH:cfa00260]

cfa_M00974

Betaine metabolism, animals, betaine => glycine [PATH:cfa00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Canis lupus familiaris (dog) [GN:cfa]

Gene

491550

probable low-specificity L-threonine aldolase 2 isoform X2 [KO:K01620] [EC:4.1.2.48]

489536

SHMT1; serine hydroxymethyltransferase, cytosolic isoform X5 [KO:K00600] [EC:2.1.2.1]

607458

SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X2 [KO:K00600] [EC:2.1.2.1]

100855679

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

612041

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

484738

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

477786

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

475495

PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

482704

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

607890

PHGDH; D-3-phosphoglycerate dehydrogenase isoform X5 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

476318

PSAT1; phosphoserine aminotransferase isoform X2 [KO:K00831] [EC:2.6.1.52]

489783

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

481262

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

477365

L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]

491498

ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

476600

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

403450

MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

403451

MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

480511

AOC3; membrane primary amine oxidase isoform X2 [KO:K00276] [EC:1.4.3.21]

490957

AOC2; retina-specific copper amine oxidase isoform X2 [KO:K00276] [EC:1.4.3.21]

481534

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

484770

AMT; aminomethyltransferase, mitochondrial precursor [KO:K00605] [EC:2.1.2.10]

485342

aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]

403978

DLD; dihydrolipoyl dehydrogenase, mitochondrial precursor [KO:K00382] [EC:1.8.1.4]

479633

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

486317

DAO; D-amino-acid oxidase isoform X2 [KO:K00273] [EC:1.4.3.3]

612589

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

485085

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

484723

CHDH; choline dehydrogenase, mitochondrial isoform X3 [KO:K00108] [EC:1.1.99.1]

481486

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

479171

BHMT; betaine--homocysteine S-methyltransferase 1 isoform X2 [KO:K00544] [EC:2.1.1.5]

488935

DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]

491177

PIPOX; peroxisomal sarcosine oxidase isoform X2 [KO:K00306] [EC:1.5.3.1 1.5.3.7]

491277

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

474905

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

611071

CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]

479991

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

486282

SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]

486281

SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]

119863918

SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721