KEGG   PATHWAY: cfa00230
Entry
cfa00230                    Pathway                                
Name
Purine metabolism - Canis lupus familiaris (dog)
Class
Metabolism; Nucleotide metabolism
Pathway map
cfa00230  Purine metabolism
cfa00230

Module
cfa_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cfa00230]
cfa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:cfa00230]
cfa_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cfa00230]
cfa_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cfa00230]
cfa_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cfa00230]
cfa_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cfa00230]
cfa_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cfa00230]
Other DBs
GO: 0006163 0042278
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
478469  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
479504  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
478006  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
479545  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
479116  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
476855  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X5 [KO:K00948] [EC:2.7.6.1]
481011  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
100686175  PRPS1L1; LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
106558085  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
611563  LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 2-like [KO:K00948] [EC:2.7.6.1]
611407  PPAT; amidophosphoribosyltransferase isoform X2 [KO:K00764] [EC:2.4.2.14]
100856570  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
489490  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
100855769  PAICS; multifunctional protein ADE2 isoform X3 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
474499  ADSL; adenylosuccinate lyase isoform X2 [KO:K01756] [EC:4.3.2.2]
488513  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
479615  APRT; adenine phosphoribosyltransferase isoform X3 [KO:K00759] [EC:2.4.2.7]
477809  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
609545  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
483309  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
482463  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
100856179  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X3 [KO:K01081] [EC:3.1.3.5]
106559724  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
474984  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
475393  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
476928  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
442945  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform 1 [KO:K00760] [EC:2.4.2.8]
476630  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
100856092  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
476638  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
480558  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
480559  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
100686107  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
100856596  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
611514  NME4; nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
102154109  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
102155863  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
102156116  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
483943  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
475022  AK9; adenylate kinase 9 isoform X15 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
486810  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
485604  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
100688937  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
486117  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
480384  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
485564  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
610721  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
609255  ITPA; inosine triphosphate pyrophosphatase isoform X3 [KO:K01519] [EC:3.6.1.66]
483028  XDH; xanthine dehydrogenase/oxidase isoform X2 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
474746  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
477123  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
488231  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
480266  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
484169  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
475178  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
476823  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X2 [KO:K10807] [EC:1.17.4.1]
481988  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X4 [KO:K10808] [EC:1.17.4.1]
482963  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
476281  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
475791  DGUOK; deoxyguanosine kinase, mitochondrial isoform X2 [KO:K00904] [EC:2.7.1.113]
482188  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
488744  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
483189  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
607357  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 isoform X5 [KO:K08041] [EC:4.6.1.1]
478624  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
482994  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
480271  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
403859  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
477625  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
487289  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
482045  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
490031  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
480087  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
479455  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X3 [KO:K12318] [EC:4.6.1.2]
482663  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
485435  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
553102  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
486671  GUCY2C; heat-stable enterotoxin receptor isoform X5 [KO:K12320] [EC:4.6.1.2]
403863  GUCY2D; retinal guanylyl cyclase 1 precursor [KO:K12321] [EC:4.6.1.2]
485179  guanylate cyclase D-like [KO:K12321] [EC:4.6.1.2]
481016  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
100688545  LOW QUALITY PROTEIN: guanylate cyclase 2G-like isoform X5 [KO:K22600] [EC:4.6.1.2]
490455  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
474762  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
403652  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
475272  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6 [KO:K13755] [EC:3.1.4.17]
100856025  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X4 [KO:K13755] [EC:3.1.4.17]
609574  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3 [KO:K18283] [EC:3.1.4.17]
610836  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
611730  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X2 [KO:K13296] [EC:3.1.4.17]
403825  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
403620  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
399653  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
486805  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X3 [KO:K13757] [EC:3.1.4.35]
403781  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
403911  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
611031  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2 [KO:K13760]
611022  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
484073  PDE10A; LOW QUALITY PROTEIN: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
488422  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
480098  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
612692  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
606901  AMPD1; LOW QUALITY PROTEIN: AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
479913  AMPD2; AMP deaminase 2 isoform X4 [KO:K01490] [EC:3.5.4.6]
479253  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
477236  ADA; adenosine deaminase isoform X3 [KO:K01488] [EC:3.5.4.4]
484249  ADA2; adenosine deaminase 2 isoform X5 [KO:K19572] [EC:3.5.4.4]
490204  AK5; adenylate kinase isoenzyme 5 isoform X3 [KO:K00939] [EC:2.7.4.3]
480712  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
489554  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
478145  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
480429  AK7; adenylate kinase 7 isoform X3 [KO:K00939] [EC:2.7.4.3]
611724  adenylate kinase isoenzyme 1-like isoform X1 [KO:K00939] [EC:2.7.4.3]
480689  AK8; adenylate kinase 8 isoform X2 [KO:K00939] [EC:2.7.4.3]
102156938  LOW QUALITY PROTEIN: adenylate kinase 2, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
102314701  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
476342  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
480491  GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
102152410  GTP:AMP phosphotransferase AK3, mitochondrial-like [KO:K00944] [EC:2.7.4.10]
102157398  GTP:AMP phosphotransferase AK3, mitochondrial-like [KO:K00944] [EC:2.7.4.10]
608853  GTP:AMP phosphotransferase AK3, mitochondrial-like [KO:K00944] [EC:2.7.4.10]
607237  NTPCR; cancer-related nucleoside-triphosphatase isoform X2 [KO:K06928] [EC:3.6.1.15]
474820  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X2 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100856150  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100683695  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
479540  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
609938  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
487221  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3 [KO:K13293] [EC:3.1.4.53]
486975  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
483996  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
488939  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
488752  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4 [KO:K18437] [EC:3.1.4.53]
100215999  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
481823  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
486463  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
478504  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
490189  UOX; uricase [KO:K00365] [EC:1.7.3.3]
486027  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
475651  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cfa00030  Pentose phosphate pathway
cfa00220  Arginine biosynthesis
cfa00250  Alanine, aspartate and glutamate metabolism
cfa00260  Glycine, serine and threonine metabolism
cfa00340  Histidine metabolism
cfa00630  Glyoxylate and dicarboxylate metabolism
cfa00730  Thiamine metabolism
cfa00740  Riboflavin metabolism
cfa00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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