KEGG   PATHWAY: clv00260
Entry
clv00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Columba livia (rock pigeon)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
clv00260  Glycine, serine and threonine metabolism
clv00260

Module
clv_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:clv00260]
clv_M00047  Creatine pathway [PATH:clv00260]
clv_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:clv00260]
clv_M00555  Betaine biosynthesis, choline => betaine [PATH:clv00260]
clv_M00621  Glycine cleavage system [PATH:clv00260]
clv_M00974  Betaine metabolism, animals, betaine => glycine [PATH:clv00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Columba livia (rock pigeon) [GN:clv]
Gene
106145842  LOW QUALITY PROTEIN: uncharacterized protein LOC106145842 [KO:K01620] [EC:4.1.2.48]
102097870  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
102084498  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
102084145  AGXT; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
102096371  GRHPR; LOW QUALITY PROTEIN: glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102093452  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
102091139  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
102089457  BPGM; bisphosphoglycerate mutase isoform X1 [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102096230  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102085805  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
102085080  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
102094565  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
102092479  L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]
102093270  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
102088179  amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
102088495  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
102095916  LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
102088654  LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
102093548  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
102097349  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
102096110  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
102096548  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
102098809  LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
102087277  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102083453  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
102093632  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
102089905  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
102091436  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
102097034  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
102091750  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
102092096  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
102089708  SARDH; LOW QUALITY PROTEIN: sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
102096572  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
102084955  LOW QUALITY PROTEIN: cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
102086099  cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
102092517  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
102097055  uncharacterized protein LOC102097055 [KO:K01754] [EC:4.3.1.19]
102085605  SDSL; serine dehydratase-like isoform X2 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102098018  uncharacterized protein LOC102098018 [KO:K20498] [EC:4.3.1.18]
102089987  SRR; LOW QUALITY PROTEIN: serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
clv00010  Glycolysis / Gluconeogenesis
clv00020  Citrate cycle (TCA cycle)
clv00230  Purine metabolism
clv00250  Alanine, aspartate and glutamate metabolism
clv00270  Cysteine and methionine metabolism
clv00290  Valine, leucine and isoleucine biosynthesis
clv00330  Arginine and proline metabolism
clv00470  D-Amino acid metabolism
clv00564  Glycerophospholipid metabolism
clv00600  Sphingolipid metabolism
clv00620  Pyruvate metabolism
clv00630  Glyoxylate and dicarboxylate metabolism
clv00640  Propanoate metabolism
clv00860  Porphyrin metabolism
clv00920  Sulfur metabolism
KO pathway
ko00260   
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