KEGG   PATHWAY: cvg00270
Entry
cvg00270                    Pathway                                
Name
Cysteine and methionine metabolism - Cyprinodon variegatus (sheepshead minnow)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
cvg00270  Cysteine and methionine metabolism
cvg00270

Module
cvg_M00035  Methionine degradation [PATH:cvg00270]
cvg_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cvg00270]
Other DBs
GO: 0006534 0006555
Organism
Cyprinodon variegatus (sheepshead minnow) [GN:cvg]
Gene
107087556  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
107089769  ccbl1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
107082414  kynurenine--oxoglutarate transaminase 3-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
107104501  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
107098785  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
107104210  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
107093785  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
107092484  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
107092421  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
107097337  homocysteine S-methyltransferase YbgG-like [KO:K00547] [EC:2.1.1.10]
107087627  mtr; methionine synthase [KO:K00548] [EC:2.1.1.13]
107092703  S-adenosylmethionine synthase isoform type-2-like [KO:K00789] [EC:2.5.1.6]
107090824  S-adenosylmethionine synthase isoform type-1-like isoform X1 [KO:K00789] [EC:2.5.1.6]
107090334  methionine adenosyltransferase 2 subunit beta-like [KO:K00789] [EC:2.5.1.6]
107102175  S-adenosylmethionine synthase isoform type-2-like [KO:K00789] [EC:2.5.1.6]
107087284  S-adenosylmethionine synthase isoform type-2 [KO:K00789] [EC:2.5.1.6]
107093278  amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
107086877  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
107086975  sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
107095862  mtap; S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
107098324  laccase domain-containing protein 1-like [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
107098600  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
107094047  apip; methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
107088849  adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107089575  tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
107099630  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
107099631  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
107099633  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
107099634  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
107099636  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
107082273  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
107103271  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
107084845  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
107083108  dnmt1; DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
107082872  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
107095834  dnmt3a; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
107096772  dnmt3b; DNA (cytosine-5)-methyltransferase 3B [KO:K17399] [EC:2.1.1.37]
107090731  uncharacterized protein LOC107090731 [KO:K17399] [EC:2.1.1.37]
107096773  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
107103608  adenosylhomocysteinase 2-like [KO:K01251] [EC:3.13.2.1]
107099554  ahcyl2; adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
107093440  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
107087505  ahcyl1; adenosylhomocysteinase 2 isoform X1 [KO:K01251] [EC:3.13.2.1]
107085649  adenosylhomocysteinase 2-like [KO:K01251] [EC:3.13.2.1]
107099278  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
107097097  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
107085798  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107084563  gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
107087938  gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]
107088564  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
107092280  cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
107091903  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
107081991  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
107105077  got2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
107084247  mpst; 3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
107087154  thiosulfate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
107087159  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
107087161  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
107087167  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
107101633  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
107085436  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
107095047  L-lactate dehydrogenase C chain isoform X1 [KO:K00016] [EC:1.1.1.27]
107088625  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
107094037  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
107089625  mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
107086831  sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
107101557  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
107093541  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107085296  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
cvg00010  Glycolysis / Gluconeogenesis
cvg00250  Alanine, aspartate and glutamate metabolism
cvg00260  Glycine, serine and threonine metabolism
cvg00290  Valine, leucine and isoleucine biosynthesis
cvg00430  Taurine and hypotaurine metabolism
cvg00480  Glutathione metabolism
cvg00620  Pyruvate metabolism
cvg00640  Propanoate metabolism
cvg00770  Pantothenate and CoA biosynthesis
cvg00900  Terpenoid backbone biosynthesis
cvg00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

DBGET integrated database retrieval system