KEGG   PATHWAY: ecra03320
Entry
ecra03320                   Pathway                                
Name
PPAR signaling pathway - Etheostoma cragini (Arkansas darter)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
ecra03320  PPAR signaling pathway
ecra03320

Organism
Etheostoma cragini (Arkansas darter) [GN:ecra]
Gene
117938982  cd36; platelet glycoprotein 4 isoform X1 [KO:K06259]
117957426  slc27a1a; long-chain fatty acid transport protein 1a [KO:K08745] [EC:6.2.1.-]
117958138  long-chain fatty acid transport protein 1-like isoform X1 [KO:K08745] [EC:6.2.1.-]
117959514  slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
117949635  zgc:101540; hsFATP2a_ACSVL_like domain-containing protein [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117947427  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117947432  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117959441  slc27a6; long-chain fatty acid transport protein 6 [KO:K08749]
117959442  long-chain fatty acid transport protein 6 [KO:K08749]
117944953  fatty acid-binding protein, liver-type [KO:K08750]
117934960  fatty acid-binding protein, intestinal-like [KO:K08751]
117955833  fabp2; fatty acid-binding protein, intestinal [KO:K08751]
117957031  fabp3; fatty acid-binding protein, heart [KO:K08752]
117957047  fabp4a; fatty acid binding protein 4a [KO:K08752]
117946773  fabp4b; fatty acid binding protein 4b [KO:K08753]
117951480  gastrotropin-like [KO:K08755]
117954381  fabp6; gastrotropin [KO:K08755]
117936190  fabp7a; fatty acid binding protein 7, brain, a [KO:K08756]
117961038  fatty acid-binding protein, brain [KO:K08756]
117938421  pparaa; peroxisome proliferator-activated receptor alpha a [KO:K07294]
117948487  pparab; peroxisome proliferator-activated receptor alpha b [KO:K07294]
117958929  rxraa; retinoic acid receptor RXR-alpha-A isoform X1 [KO:K08524]
117946952  rxrbb; retinoic acid receptor RXR-beta-B isoform X1 [KO:K08524]
117956557  rxrba; retinoic acid receptor RXR-beta-A isoform X1 [KO:K08525]
117950591  rxrgb; retinoic acid receptor RXR-gamma-B isoform X1 [KO:K08526]
117948315  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
117943530  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
117959290  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
117956276  type-4 ice-structuring protein LS-12-like [KO:K08758]
117945689  type-4 ice-structuring protein LS-12-like [KO:K08758]
117940497  bactericidal permeability-increasing protein-like [KO:K08761]
117941373  pltp; phospholipid transfer protein isoform X1 [KO:K08761]
117946363  me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
117953354  me3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
117949003  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
117937256  scd; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
117960819  scdb; stearoyl-CoA desaturase b isoform X1 [KO:K00507] [EC:1.14.19.1]
117954613  cytochrome P450 7A1 [KO:K00489] [EC:1.14.14.23]
117954895  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
117944866  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
117952801  si:dkey-91i10.3; cytochrome P450 [KO:K00488] [EC:1.14.15.15]
117939647  si:ch211-113j14.1; sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
117952705  dbi; acyl-CoA-binding protein [KO:K08762]
117951001  lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
117951002  lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
117955303  acsl1a; long-chain-fatty-acid--CoA ligase 1a isoform X1 [KO:K01897] [EC:6.2.1.3]
117955448  acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
117944238  acsl2; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
117951363  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
117937221  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
117952050  acsl4a; LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
117953627  acsl3b; long-chain-fatty-acid--CoA ligase 3b [KO:K01897] [EC:6.2.1.3]
117939636  acsl3a; long-chain-fatty-acid--CoA ligase 3a [KO:K01897] [EC:6.2.1.3]
117949687  acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 [KO:K15013] [EC:6.2.1.3]
117944677  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
117951134  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:6.2.1.3]
117953467  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
117953992  scp2a; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
117934874  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
117935220  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
117960901  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
117949346  cpt1ab; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
117949553  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
117936588  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
117957697  cpt1cb; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
117949864  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
117939622  acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
117953943  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
117950302  angiopoietin-related protein 4-like [KO:K08767]
117953634  angptl4; angiopoietin-related protein 4 [KO:K08767]
117960909  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
117934640  plin2; perilipin-2 isoform X1 [KO:K17284]
117955596  perilipin-2-like isoform X1 [KO:K17284]
117940804  uncharacterized protein LOC117940804 [KO:K17284]
117955821  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117941692  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117937188  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117943644  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
117937980  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
117952985  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
117939157  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
117944133  aqp7; aquaporin-7 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
ecra00071  Fatty acid degradation
ecra00120  Primary bile acid biosynthesis
ecra00564  Glycerophospholipid metabolism
ecra04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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