KEGG   PATHWAY: hsy04144
Entry
hsy04144                    Pathway                                
Name
Endocytosis - Hydractinia symbiolongicarpus
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
hsy04144  Endocytosis
hsy04144

Other DBs
GO: 0006897
Organism
Hydractinia symbiolongicarpus [GN:hsy]
Gene
130629144  ADP-ribosylation factor 6 [KO:K07941]
130656788  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
130654971  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
130612357  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
130654786  clathrin light chain A-like [KO:K04645]
130623354  clathrin heavy chain 1-like [KO:K04646]
130662854  AP-2 complex subunit alpha-2-like [KO:K11824]
130623727  AP-2 complex subunit beta-like [KO:K11825]
130641414  AP-2 complex subunit mu-like [KO:K11826]
130640863  AP-2 complex subunit sigma [KO:K11827]
130640782  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
130641160  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
130641987  activin receptor type-1C-like [KO:K04674] [EC:2.7.11.30]
130630399  uncharacterized protein LOC130630399 [KO:K04679]
130655592  fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
130636193  fibroblast growth factor receptor-like [KO:K05093] [EC:2.7.10.1]
130644346  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
130644345  fibroblast growth factor receptor 4-like isoform X1 [KO:K05094] [EC:2.7.10.1]
130647317  fibroblast growth factor receptor 2-like [KO:K05094] [EC:2.7.10.1]
130648124  fibroblast growth factor receptor 2-like [KO:K05094] [EC:2.7.10.1]
130636380  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
130644807  SH3 domain-containing kinase-binding protein 1-like [KO:K12470]
130635439  endophilin-A3-like [KO:K11247]
130636637  endophilin-A3-like [KO:K11247]
130612227  endophilin-B1-like [KO:K11248]
130621590  bridging integrator 2-like [KO:K12562]
130654091  epsin-2-like [KO:K12471]
130630557  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
130621645  spartin-like [KO:K19366]
130641376  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
130644378  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
130612339  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
130640785  E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
130641161  E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
130613906  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
130644746  low density lipoprotein receptor adapter protein 1-like isoform X1 [KO:K12474]
130623550  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
130644920  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
130635717  beta-arrestin-1-like [KO:K04439]
130656221  actin-related protein 2 [KO:K17260]
130641906  actin-related protein 3 [KO:K18584]
130649517  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
130649518  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
130622685  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
130623341  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
130614236  actin-related protein 2/3 complex subunit 4 [KO:K05755]
130612755  actin-related protein 2/3 complex subunit 5-B-like [KO:K05754]
130626057  heat shock cognate 71 kDa protein-like [KO:K03283]
130644698  heat shock cognate 71 kDa protein-like [KO:K03283]
130621426  heat shock cognate 71 kDa protein-like [KO:K03283]
130623545  heat shock cognate 71 kDa protein-like [KO:K03283]
130625006  WASH complex subunit 4-like isoform X1 [KO:K18465]
130654970  WASH complex subunit 5-like [KO:K18464]
130654759  WASH complex subunit 3-like isoform X1 [KO:K18463]
130626132  F-actin-capping protein subunit alpha-1-like [KO:K10364]
130642100  F-actin-capping protein subunit beta-like [KO:K10365]
130623953  vacuolar protein sorting-associated protein 29-like [KO:K18467]
130628975  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
130614867  vacuolar protein sorting-associated protein 35-like [KO:K18468]
130645759  sorting nexin-12-like [KO:K17918]
130628712  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
130626044  ras-related protein rab7 [KO:K07897]
130648785  hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182]
130647032  signal transducing adapter molecule 2-like isoform X1 [KO:K04705]
130654093  tumor susceptibility gene 101 protein-like isoform X1 [KO:K12183]
130662581  uncharacterized protein LOC130662581 [KO:K12186]
130654011  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
130636105  vacuolar protein sorting-associated protein 37A-like isoform X1 [KO:K12185]
130623857  uncharacterized protein LOC130623857 [KO:K12185]
130621656  vacuolar-sorting protein SNF8-like [KO:K12188]
130655969  vacuolar protein-sorting-associated protein 36-like [KO:K12190]
130614549  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
130648949  charged multivesicular body protein 6-A-like [KO:K12195]
130614200  charged multivesicular body protein 4c-like isoform X1 [KO:K12194]
130645254  charged multivesicular body protein 3-like [KO:K12193]
130640957  charged multivesicular body protein 2a-like [KO:K12191]
130641671  charged multivesicular body protein 2b-like [KO:K12192]
130645488  charged multivesicular body protein 7-like [KO:K15053]
130613891  vacuolar protein sorting-associated protein 4-like isoform X1 [KO:K12196]
130614092  uncharacterized protein LOC130614092 [KO:K12196]
130644676  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
130644747  charged multivesicular body protein 1b-like [KO:K12197]
130614765  charged multivesicular body protein 1a-like [KO:K12197]
130622028  charged multivesicular body protein 5-like [KO:K12198]
130641771  IST1 homolog [KO:K19476]
130622779  programmed cell death 6-interacting protein-like [KO:K12200]
130641619  maspardin-like [KO:K19367]
130644631  maspardin-like [KO:K19367]
130634057  sorting nexin-2-like [KO:K17917]
130625808  sorting nexin-5-like [KO:K17920]
130656628  sorting nexin-32-like [KO:K17920]
130625498  ras-like GTP-binding protein RHO [KO:K04513]
130626139  ras-like GTP-binding protein RHO [KO:K04513]
130626142  ras-like GTP-binding protein RHO [KO:K04513]
130656639  ras-like GTP-binding protein Rho1 [KO:K04513]
130641821  ras-like GTP-binding protein RHO [KO:K04513]
130655536  folate receptor gamma-like [KO:K13649]
130641562  ras-related protein Rab-5B-like [KO:K07888]
130623773  rab GTPase-binding effector protein 1-like isoform X1 [KO:K12480]
130625591  rabenosyn-5-like [KO:K12481]
130628773  RUN and FYVE domain-containing protein 2-like [KO:K12482]
130640982  EH domain-containing protein 3-like [KO:K12483]
130636180  vacuolar protein sorting-associated protein 45-like [KO:K12479]
130637756  vacuolar protein sorting-associated protein 45-like [KO:K12479]
130622776  sorting nexin-4-like isoform X1 [KO:K17919]
130647276  ras-related protein Rab-22A-like [KO:K07891]
130647278  ras-related protein Rab-22A-like [KO:K07891]
130648317  ras-related protein Rab-22A-like [KO:K07891]
130648318  ras-related protein Rab-22A-like [KO:K07891]
130654348  ras-related protein Rab-10-like [KO:K07903]
130653897  GTP-binding protein Di-Ras1-like [KO:K07901]
130656338  ras-related protein Rab-8A-like [KO:K07901]
130623340  ras-related protein Rab-35-like [KO:K07876]
130656394  ras-related protein Rab-11B-like [KO:K07904]
130641477  ras-related protein Rab-11B-like [KO:K07904]
130642256  uncharacterized protein LOC130642256 [KO:K07904]
130656710  protrudin-like isoform X1 [KO:K19368]
130621917  kinesin heavy chain-like [KO:K10396]
130649268  rab11 family-interacting protein 4-like [KO:K12485]
130613791  partitioning defective 6 homolog gamma-like [KO:K06093]
130641021  protein kinase C iota type-like [KO:K06069] [EC:2.7.11.13]
130641416  cell division control protein 42 homolog [KO:K04393]
130641417  cdc42 homolog [KO:K04393]
130654779  stromal membrane-associated protein 1-like [KO:K12486]
130623421  ARF GTPase-activating protein GIT1-like isoform X1 [KO:K12487]
130647791  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
130641120  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
130644182  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
130622771  centaurin-gamma-1A-like [KO:K12491]
130654132  ADP-ribosylation factor GTPase-activating protein 1-like [KO:K12492]
130654239  ADP-ribosylation factor GTPase-activating protein 3-like [KO:K12493]
130628968  PH and SEC7 domain-containing protein 2-like [KO:K12494]
130648806  cytohesin-1-like [KO:K18441]
130655640  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like isoform X1 [KO:K18442]
130647652  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like [KO:K18443]
130649275  ADP-ribosylation factor 2-like [KO:K07937]
130635514  ADP-ribosylation factor 1-like 2 [KO:K07937]
130635601  ADP-ribosylation factor 1-like 2 [KO:K07937]
130621213  ADP-ribosylation factor 1-like 2 [KO:K07937]
130621788  ADP-ribosylation factor 1-like 2 [KO:K07937]
130625592  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
hsy04070  Phosphatidylinositol signaling system
hsy04130  SNARE interactions in vesicular transport
hsy04142  Lysosome
hsy04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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