KEGG   PATHWAY: ifu00260
Entry
ifu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Ictalurus furcatus (blue catfish)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ifu00260  Glycine, serine and threonine metabolism
ifu00260

Module
ifu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ifu00260]
ifu_M00047  Creatine pathway [PATH:ifu00260]
ifu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ifu00260]
ifu_M00555  Betaine biosynthesis, choline => betaine [PATH:ifu00260]
ifu_M00621  Glycine cleavage system [PATH:ifu00260]
ifu_M00974  Betaine metabolism, animals, betaine => glycine [PATH:ifu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ictalurus furcatus (blue catfish) [GN:ifu]
Gene
128617384  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
128614638  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
128600223  serine hydroxymethyltransferase, cytosolic-like isoform X1 [KO:K00600] [EC:2.1.2.1]
128600224  serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
128614518  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
128621363  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
128612071  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
128604503  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
128615054  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
128622063  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
128605621  pgam1a; phosphoglycerate mutase 1a [KO:K01834] [EC:5.4.2.11]
128601936  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
128611580  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
128608999  phgdh; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
128599125  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
128623967  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
128600001  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
128612778  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
128601265  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
128607950  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
128625174  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
128608779  mao; amine oxidase [flavin-containing] isoform X1 [KO:K00274] [EC:1.4.3.4]
128620467  amine oxidase [flavin-containing] A-like isoform X1 [KO:K00274] [EC:1.4.3.4]
128620469  amine oxidase [flavin-containing] A-like isoform X1 [KO:K00274] [EC:1.4.3.4]
128603643  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
128598935  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
128608066  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
128618515  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
128606438  gcsha; glycine cleavage system protein H (aminomethyl carrier), a [KO:K02437]
128614047  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
128599261  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
128622524  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
128606309  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
128606310  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
128607141  glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
128613911  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
128607647  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
128620112  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
128622897  bhmt; betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
128622543  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
128621622  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
128620169  sarcosine dehydrogenase, mitochondrial-like [KO:K00314] [EC:1.5.8.3]
128620698  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
128612581  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
128608454  cystathionine beta-synthase-like protein isoform X1 [KO:K01697] [EC:4.2.1.22]
128601987  cbsa; cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
128614859  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
128605852  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
128612323  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
128599289  LOW QUALITY PROTEIN: L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
128613475  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ifu00010  Glycolysis / Gluconeogenesis
ifu00020  Citrate cycle (TCA cycle)
ifu00230  Purine metabolism
ifu00250  Alanine, aspartate and glutamate metabolism
ifu00270  Cysteine and methionine metabolism
ifu00290  Valine, leucine and isoleucine biosynthesis
ifu00330  Arginine and proline metabolism
ifu00470  D-Amino acid metabolism
ifu00564  Glycerophospholipid metabolism
ifu00600  Sphingolipid metabolism
ifu00620  Pyruvate metabolism
ifu00630  Glyoxylate and dicarboxylate metabolism
ifu00640  Propanoate metabolism
ifu00860  Porphyrin metabolism
ifu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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