KEGG   PATHWAY: ini04120
Entry
ini04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Ipomoea nil (Japanese morning glory)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ini04120  Ubiquitin mediated proteolysis
ini04120

Other DBs
GO: 0016567
Organism
Ipomoea nil (Japanese morning glory) [GN:ini]
Gene
109178299  PnUBQ; polyubiquitin [KO:K08770]
109187755  polyubiquitin [KO:K08770]
109190585  polyubiquitin [KO:K08770]
109165785  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109157135  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109193802  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109189258  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109193947  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109175591  ubiquitin-40S ribosomal protein S27a [KO:K02977]
109159811  ubiquitin-40S ribosomal protein S27a [KO:K02977]
109182860  ubiquitin-activating enzyme E1 1-like [KO:K03178] [EC:6.2.1.45]
109159073  ubiquitin-activating enzyme E1 1-like [KO:K03178] [EC:6.2.1.45]
109163159  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
109184683  SUMO-activating enzyme subunit 1A-like [KO:K10684] [EC:6.2.1.45]
109161521  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
109161571  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
109175758  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
109180376  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
109191898  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
109178234  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
109154555  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
109188678  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
109152359  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
109162234  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
109163998  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109178089  ubiquitin-conjugating enzyme E2 5B-like [KO:K06689] [EC:2.3.2.23]
109185432  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109167674  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109146469  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109177345  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
109156403  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109165601  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
109162795  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109155804  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109152307  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
109156688  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
109186527  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
109148113  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
109147667  ubiquitin-conjugating enzyme E2 4 [KO:K10576] [EC:2.3.2.23]
109158142  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
109184883  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
109155601  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
109150701  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
109177962  SUMO-conjugating enzyme SCE1 [KO:K10577]
109189122  SUMO-conjugating enzyme SCE1-like [KO:K10577]
109153255  SUMO-conjugating enzyme SCE1-like [KO:K10577]
109188777  SUMO-conjugating enzyme UBC9 [KO:K10577]
109175672  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
109190622  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
109192426  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
109183851  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
109177789  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
109169696  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
109152983  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
109150576  ubiquitin-conjugating enzyme E2 35-like [KO:K10580] [EC:2.3.2.23]
109188230  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
109187480  ubiquitin-conjugating enzyme E2 36-like [KO:K10580] [EC:2.3.2.23]
109167339  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
109165341  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
109165351  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
109188375  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
109161406  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
109165106  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
109188316  probable ubiquitin-conjugating enzyme E2 26 [KO:K10581] [EC:2.3.2.24]
109174172  uncharacterized LOC109174172 [KO:K10581] [EC:2.3.2.24]
109159134  ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
109181707  ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
109170059  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109172714  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109174947  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
109176075  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
109165066  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
109185853  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
109161336  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
109190412  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
109152791  E3 ubiquitin-protein ligase UPL2-like [KO:K10592] [EC:2.3.2.26]
109180537  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
109173654  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
109162345  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
109168911  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
109175678  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
109176546  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
109151385  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
109194093  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109155896  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109183425  E3 ubiquitin-protein ligase SINAT3-like [KO:K04506] [EC:2.3.2.27]
109148803  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
109189164  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109177846  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
109177847  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
109177570  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
109180454  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109177568  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
109155985  COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
109188775  WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
109193840  WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
109165733  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
109179336  WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
109181862  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109160494  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
109174499  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109181818  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109174626  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
109191289  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109170653  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
109148249  E4 SUMO-protein ligase PIAL2-like [KO:K04706] [EC:2.3.2.-]
109180869  E4 SUMO-protein ligase PIAL2-like [KO:K04706] [EC:2.3.2.-]
109165433  E4 SUMO-protein ligase PIAL2-like [KO:K04706] [EC:2.3.2.-]
109157143  E4 SUMO-protein ligase PIAL2-like [KO:K04706] [EC:2.3.2.-]
109146511  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
109168553  E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
109147674  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
109186622  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
109158438  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
109170528  cullin-1-like [KO:K03347]
109175796  cullin-1-like [KO:K03347]
109191341  cullin-1-like [KO:K03347]
109165834  SKP1-like protein 1A [KO:K03094]
109150512  SKP1-like protein 1B [KO:K03094]
109163988  SKP1-like protein 1A [KO:K03094]
109161879  SKP1-like protein 1A [KO:K03094]
109178997  SKP1-like protein 1A [KO:K03094]
109178998  SKP1-like protein 1A [KO:K03094]
109191791  SKP1-like protein 1A [KO:K03094]
109191792  SKP1-like protein 1A [KO:K03094]
109174221  SKP1-like protein 1A [KO:K03094]
109174223  SKP1-like protein 1A [KO:K03094]
109174224  SKP1-like protein 1A [KO:K03094]
109183364  SKP1-like protein 1B [KO:K03094]
109184769  SKP1-like protein 1A [KO:K03094]
109158710  SKP1-like protein 18 [KO:K03094]
109158711  SKP1-like protein 18 [KO:K03094]
109166444  SKP1-like protein 1A [KO:K03094]
109166454  SKP1-like protein 1A [KO:K03094]
109166462  SKP1-like protein 1B [KO:K03094]
109149803  SKP1-like protein 1B [KO:K03094]
109152093  SKP1-like protein 1B [KO:K03094]
109167345  SKP1-like protein 1B [KO:K03094]
109170563  SKP1-like protein 1A [KO:K03094]
109174876  SKP1-like protein 1A [KO:K03094]
109174877  SKP1-like protein 1A [KO:K03094]
109153355  SKP1-like protein 1A [KO:K03094]
109153356  SKP1-like protein 1A [KO:K03094]
109153357  SKP1-like protein 1B [KO:K03094]
109153358  SKP1-like protein 1A [KO:K03094]
109191758  SKP1-like protein 1A [KO:K03094]
109191790  SKP1-like protein 1A [KO:K03094]
109156623  SKP1-like protein 1B [KO:K03094]
109156654  SKP1-like protein 1B [KO:K03094]
109170471  F-box protein SKP2A-like [KO:K03875]
109173866  transcription elongation factor B polypeptide 1 [KO:K03872]
109192408  uncharacterized LOC109192408 [KO:K03873]
109153708  cullin-3A-like [KO:K03869]
109166225  cullin-3A-like [KO:K03869]
109180532  cullin-3A-like [KO:K03869]
109151334  cullin-3A-like [KO:K03869]
109166525  cullin-4-like [KO:K10609]
109153814  cullin-4 [KO:K10609]
109174939  DNA damage-binding protein 1 [KO:K10610]
109185088  DNA damage-binding protein 1-like [KO:K10610]
109163509  protein DAMAGED DNA-BINDING 2 [KO:K10140]
109149420  DNA excision repair protein ERCC-8-like [KO:K10570]
109181663  light-mediated development protein DET1 [KO:K10571]
109182621  RING-box protein 1B-like [KO:K03358]
109177697  anaphase-promoting complex subunit 2 [KO:K03349]
109185617  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
109169350  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
109179330  cell division cycle 20.5, cofactor of APC complex-like [KO:K03363]
109188872  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
109153246  protein FIZZY-RELATED 2-like [KO:K03364]
109147956  protein FIZZY-RELATED 3 [KO:K03364]
109147962  anaphase-promoting complex subunit 1 [KO:K03348]
109192330  cell division cycle protein 27 homolog B [KO:K03350]
109159078  anaphase-promoting complex subunit 4 [KO:K03351]
109148210  anaphase-promoting complex subunit 5-like [KO:K03352]
109163638  anaphase-promoting complex subunit 5-like [KO:K03352]
109181733  anaphase-promoting complex subunit 6 [KO:K03353]
109174964  anaphase-promoting complex subunit 7 [KO:K03354]
109149708  anaphase-promoting complex subunit 8-like [KO:K03355]
109191146  anaphase-promoting complex subunit 8-like [KO:K03355]
109180895  anaphase-promoting complex subunit 10-like [KO:K03357]
109159509  anaphase-promoting complex subunit 10 [KO:K03357]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
ini03050  Proteasome
KO pathway
ko04120   
LinkDB

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