KEGG   PATHWAY: lcm00260
Entry
lcm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Latimeria chalumnae (coelacanth)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
lcm00260  Glycine, serine and threonine metabolism
lcm00260

Module
lcm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:lcm00260]
lcm_M00047  Creatine pathway [PATH:lcm00260]
lcm_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:lcm00260]
lcm_M00555  Betaine biosynthesis, choline => betaine [PATH:lcm00260]
lcm_M00621  Glycine cleavage system [PATH:lcm00260]
lcm_M00974  Betaine metabolism, animals, betaine => glycine [PATH:lcm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Latimeria chalumnae (coelacanth) [GN:lcm]
Gene
102346865  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
102355076  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
102353118  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
102364803  AGXT; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
102348917  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102347981  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102349186  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102347757  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
102361919  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
102348652  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
102350982  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102355216  PHGDH; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102359147  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
102360660  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
102346076  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
102367639  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
102345272  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
102347393  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
102360205  GCAT; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
102364297  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
102360320  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
102352626  ALAS1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]
102357971  ALAS2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]
102349352  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
106703932  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
102352055  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
102352327  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
102366363  AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
102366117  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
102347278  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
102355395  GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
102365617  AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
102356534  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
102363238  GCSH; glycine cleavage system protein H [KO:K02437]
102345246  DAO; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
102356225  AGXT2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102352460  GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
102360926  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
102355562  CHDH; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
102356888  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
102351553  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
102353346  dimethylglycine dehydrogenase, mitochondrial-like [KO:K00315] [EC:1.5.8.4]
102358232  PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
102358838  SARDH; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]
102360222  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
102364567  CBS; cystathionine-beta-synthase [KO:K01697] [EC:4.2.1.22]
102355425  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
102360189  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
102358913  L-threonine ammonia-lyase-like [KO:K01754] [EC:4.3.1.19]
102363224  SDSL; serine dehydratase like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102360714  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
lcm00010  Glycolysis / Gluconeogenesis
lcm00020  Citrate cycle (TCA cycle)
lcm00230  Purine metabolism
lcm00250  Alanine, aspartate and glutamate metabolism
lcm00270  Cysteine and methionine metabolism
lcm00290  Valine, leucine and isoleucine biosynthesis
lcm00330  Arginine and proline metabolism
lcm00470  D-Amino acid metabolism
lcm00564  Glycerophospholipid metabolism
lcm00600  Sphingolipid metabolism
lcm00620  Pyruvate metabolism
lcm00630  Glyoxylate and dicarboxylate metabolism
lcm00640  Propanoate metabolism
lcm00860  Porphyrin metabolism
lcm00920  Sulfur metabolism
KO pathway
ko00260   
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