Entry
Name
Spliceosome - Macaca fascicularis (crab-eating macaque)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Macaca fascicularis (crab-eating macaque) [GN:
mcf ]
Gene
102133780 DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X2 [KO:K12815 ] [EC:5.6.2.6 ]
102133511 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086 ]
102124807 SNRPD2; small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096 ]
123574065 LOW QUALITY PROTEIN: small nuclear ribonucleoprotein E-like [KO:K11097 ]
107127486 putative small nuclear ribonucleoprotein G-like protein 15 [KO:K11099 ]
101866590 SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X2 [KO:K11093 ]
102133662 SNRPC; U1 small nuclear ribonucleoprotein C isoform X3 [KO:K11095 ]
101926040 PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X5 [KO:K12821 ]
102120501 PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X2 [KO:K12821 ]
101866694 TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824 ]
102146265 U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836 ]
102147005 U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836 ]
102140484 U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837 ]
102133738 PUF60; poly(U)-binding-splicing factor PUF60 isoform X3 [KO:K12838 ]
102135509 SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839 ]
102144625 CHERP; calcium homeostasis endoplasmic reticulum protein isoform X2 [KO:K12841 ]
102146372 U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842 ]
102144654 LSM2; U6 snRNA-associated Sm-like protein LSm2 isoform X1 [KO:K12621 ]
102123507 LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X2 [KO:K12624 ]
102130530 PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843 ]
102136784 PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662 ]
102123803 SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
101866251 USP39; ubiquitin carboxyl-terminal hydrolase 39 isoform X1 [KO:K12847 ]
101926477 SART1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984 ]
102125298 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852 ]
101865580 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
102143176 HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283 ]
102140949 ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875 ]
101865112 NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882 ]
102119030 NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883 ]
135965297 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
101925993 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741 ]
107127877 HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741 ]
102142924 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
135966198 heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741 ]
102137867 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
101925475 HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [KO:K12884 ]
101864797 RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885 ]
101865058 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
102124966 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein K-like [KO:K12886 ]
102136432 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X7 [KO:K12887 ]
101926491 HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
101865193 SRSF1; serine/arginine-rich splicing factor 1 isoform X4 [KO:K12890 ]
101926639 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
101865347 SRSF7; serine/arginine-rich splicing factor 7 isoform X2 [KO:K12896 ]
102121646 TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
101867180 SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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