KEGG   PATHWAY: mdo00830
Entry
mdo00830                    Pathway                                
Name
Retinol metabolism - Monodelphis domestica (gray short-tailed opossum)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
mdo00830  Retinol metabolism
mdo00830

Other DBs
GO: 0006776
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100031779  BCO1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]
100015889  alcohol dehydrogenase S chain-like [KO:K13951] [EC:1.1.1.1]
100015820  alcohol dehydrogenase class 4 mu/sigma chain-like [KO:K13951] [EC:1.1.1.1]
100015858  ADH7; alcohol dehydrogenase class 4 mu/sigma chain [KO:K13951] [EC:1.1.1.1]
100015779  alcohol dehydrogenase class 4 mu/sigma chain [KO:K13951] [EC:1.1.1.1]
100618327  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100010099  DHRS3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
100030652  DHRS4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
100017287  DHRS9; dehydrogenase/reductase 9 [KO:K11149] [EC:1.1.-.-]
100013649  RDH8; retinol dehydrogenase 8 (all-trans) [KO:K11150] [EC:1.1.1.-]
100026196  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
100017135  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
100020635  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
100028370  RDH11; retinol dehydrogenase 11 (all-trans/9-cis/11-cis) [KO:K11152] [EC:1.1.1.300]
100028379  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
100011050  RDH16; retinol dehydrogenase 16 (all-trans) [KO:K11154] [EC:1.1.1.-]
100029976  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
100017333  LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) [KO:K00678] [EC:2.3.1.135]
100018271  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
100014456  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
100018570  PNPLA4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]
100030329  RPE65; RPE65, retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
100029977  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
100016433  AOX2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
100030014  AOX4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
107648868  aldehyde oxidase 3-like [KO:K00157] [EC:1.2.3.1]
100020742  ALDH1A1; aldehyde dehydrogenase 1 family, member A1 [KO:K07249] [EC:1.2.1.36]
100020879  ALDH1A6; aldehyde dehydrogenase 1 family, member A6 [KO:K07249] [EC:1.2.1.36]
100019941  ALDH1A2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]
100020791  ALDH1A4; aldehyde dehydrogenase 1 family, member A4 [KO:K07249] [EC:1.2.1.36]
100020853  ALDH1A5; aldehyde dehydrogenase 1 family, member A5 [KO:K07249] [EC:1.2.1.36]
100616732  ALDH1A3; aldehyde dehydrogenase 1 family member A3 [KO:K07249] [EC:1.2.1.36]
100023867  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
100023898  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
100029871  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100029908  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
100015520  cytochrome P450 2A13-like [KO:K07411] [EC:1.14.14.1]
100018858  cytochrome P450 2A13 [KO:K07411] [EC:1.14.14.1]
100018958  cytochrome P450 2B6-like [KO:K17709] [EC:1.14.14.-]
100018927  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
100023204  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100023235  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100023149  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100026569  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100026598  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100026637  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100028608  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100020348  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100026618  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100018994  cytochrome P450 2S1-like [KO:K07420] [EC:1.14.14.1]
100013238  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100010783  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100013114  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
100010698  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100010745  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100010820  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100028230  cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
100023663  cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
100010818  UGT2A1; UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
100025642  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
100025419  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
100025445  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
100025470  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
100030337  all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
100030257  RETSAT; retinol saturase [KO:K09516] [EC:1.3.99.23]
100026810  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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