KEGG   PATHWAY: mleu04727
Entry
mleu04727                   Pathway                                
Name
GABAergic synapse - Mandrillus leucophaeus (drill)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
mleu04727  GABAergic synapse
mleu04727

Other DBs
GO: 0051932
Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105544849  SLC38A1; sodium-coupled neutral amino acid transporter 1 isoform X1 [KO:K14990]
105544842  SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
105545542  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
105535216  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
105553924  LOW QUALITY PROTEIN: glutamate decarboxylase 2-like [KO:K01580] [EC:4.1.1.15]
105548080  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
105555205  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
105535777  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
105542602  ABAT; 4-aminobutyrate aminotransferase, mitochondrial isoform X1 [KO:K13524] [EC:2.6.1.19 2.6.1.22]
105540758  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
105535172  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
105536046  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
105529502  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 isoform X1 [KO:K05175]
105529504  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
105538263  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
105540756  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
105535819  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
105529505  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
105533234  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X1 [KO:K05186]
105540769  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
105529500  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
105544661  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
105533037  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
105535171  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
105530919  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
105532068  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105540992  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105538055  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105535793  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105548239  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105545146  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105539692  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105553084  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
105546813  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
105542006  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105549902  GABARAP; gamma-aminobutyric acid receptor-associated protein isoform X1 [KO:K08341]
105555139  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
105535419  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
105535446  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
105549628  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
105542291  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
105542767  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 isoform X1 [KO:K05190]
105542768  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
105544371  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
105550082  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105543338  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105529889  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105543978  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105547696  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
105547155  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105548308  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
105549294  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
105548989  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105543912  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105530947  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105533439  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105544663  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
105543670  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105541805  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105539926  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105544043  GNB5; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105553607  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
105549051  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105550079  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
105550105  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105535557  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105553288  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105541972  uncharacterized protein LOC105541972 [KO:K08041] [EC:4.6.1.1]
105535662  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105534027  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105532738  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105533183  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105544918  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105545643  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
105530895  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105541508  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105542557  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
105549530  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
105529872  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
105549546  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
105529905  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
105534205  GLUL; glutamine synthetase isoform X1 [KO:K01915] [EC:6.3.1.2]
105548991  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
105547733  SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
mleu00020  Citrate cycle (TCA cycle)
mleu00250  Alanine, aspartate and glutamate metabolism
mleu04144  Endocytosis
mleu04721  Synaptic vesicle cycle
KO pathway
ko04727   
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